Developmental Disturbances Flashcards
Inherited disorder ave
Caused by abnormality in genetic makeup
Congenital disorder are
’ Present at birth
May be inherited or developmental cause of congenital disorder is unknown
Disorders are due to
Abnormalities in differentiation of dental Lamina and tooth germs
8 anomalies of teeth
No. Of teeth
Size of teeth
Form of teeth (shape )
Tooth structure ] abnormalities in histo differentiation
Anodontia is
Complete congenital absence of teeth in one or more dentition. Failure of teeth to develop (same as genesis
Of teeth)
Hypodontia is
Having les than 6 congenitally missing teeth (partial anodontia)
Oligodontia is
Subdivision of hypodontia ‘ having 6 or more congenitally missing teeth
Hyper dontia is also called
Polydontia - presence of extra teeth
Maybe single ol multiple as in
Cleidocranial dysplasia
Anodontia is
Rare condition - mutation is some of regulatory control genes
When it occur it is usually a part of craniofacial and developmental syndromes like ectodermal dysplasia syndrome
Ectodermal dysplasia is hereditary or congenital
Hereditary
5 clinical features of ectodermal dysplasia syndrome
Hypotrichosis (lack of hair)
Dental anomalies ( anodontia, hypodontia, oligodontia)
Hypohydrosis and anhydrosis (dryness of skin)
Oncyhodysplasia (abnormal nails)
Depressed nasal brush frontal bossing prominent ears parting averted lips
Dental anomalies may include
Anodontia hypodontia taurodontism of deciduous molars
Permanent dentition limited to
Maxilla- CI first molar and canine
Mandible- canine first pm and first molar
Deficient alveolar ridges associated with hypodontia
Underdeveloped jaws
Malformed teeth
Cleft lip palate
Absence of lingual frenulum
Hypodontia is more or less Mormon than anodontia
More common
Hypodontia asssociated with
Ectodermal dysplasia condition
Genes affected in hypodontia
Pax9 and MSX1 genes transcription factors as chromosome 14 involved
Genes encodes transcription factors that function in development of derivatives of pharyngeal pouch (teeth, skeleton, thymus)
Teeth most commonly affected in hypodontia is
Permanent upper lateral incisor lower 2nd pm and 3rd molars are missing
In deciduous dentition central incisor are commonly affected misssing with failure of permanent successor formation
Hypodontia in deciduous dentition is uncommon
Supernumerary teeth or hyperdontia is associated with what defects
Cleft palate, cleidocranial dysplasia and gardners syndrome
Hyperdontia may develop in any
Tooth bearing area but occur most frequently in
Anterior and molar region of maxilla
Followed by premolar region of mandible
Hyperdontia is more common in
Females
Hyperdontia can arise problems that are
May prevent eruption cause malposition or resorption of adjacent teeth
Majority have conical peg shape
Cleidocranial dysplasia is inherited as
Autosomal dominant trait chromosome 6 the gene encodes (BFA_ protein necessary for skeletal development