Developmental

Question 1

Mesodermal cells that induce formation of the neural plate beginning at Hensen’s node

Answer 1

Notochord

Question 2

Neural plate is first recognized when?

Answer 2

middle of third weeks after conception

Question 3

Neural folds fuse by

Answer 3

day 24

Question 4

closure of neural tube occurs by

Answer 4

endo of fourth week of gestation

Question 5

transverse differentiation of neural tube:
dorsolateral: alar plates
ventrolateral: basla plates
what structure separates them

Answer 5

sulcus limitans

Question 6

dorsal patterning signas from

Answer 6

BMP

Wnt

Question 7

ventral patterning signals

Answer 7

Shh

Question 8

what results from defective notochord induction of the neuroectoderm

Answer 8

anencephaly

Question 9

enlargement of occipital horns

Answer 9

colpocephaly

Question 10

subtype of holoprosencephaly characterized by presence of interhemispheric fissure and ventricles but absent septum pellucidum

Answer 10

Lobar holoprosencpehaly

other types:
Aloba
Semilobar

Question 11

primary germinal zone of neural tube

Answer 11

ventricular zone

Question 12

secondary germinal zone

Answer 12

external granule layer of cerebellum

Question 13

guide the migration of neuroblasts

Answer 13

radial glial cells

Question 14

wall lining in porencephaly vs schizencephaly

Answer 14

porencephaly: gliotic white matter
schizencephaly: heterotropic gray matter

Question 15

proteins essential for neuronal migration

Answer 15

doublecortin and LIS1

Question 16

organization of laminae in the cerebral cortex depends on what protein

Answer 16

Reelin