Development of the Urinary System

Question 1

The urinary system is generated from what type of primordial tissue?

Answer 1

intermediate mesoderm

increases in size and pushin into the coelimic cavity formign the urogenital ridge

lateral = nephrogenic ridge

medial = genital ridge

Question 2

What structure is formed from the nephrogenic cord?

what are its features?

Answer 2

• pronephric kidney
  
  • present during week 4
  • 7-10 nephric tubules
  • present in cervical region
  • external and internal glomeruli
  • does NOT function physiologically

Question 3

What happens once the pronephric duct forms?

Answer 3

induces mesonephric kidney development

• starts formign week 4, regrsses in week 10
  
  • secretes urine beginning week 6
• throacic and lumbar region
• drained by the mesonephric duct
• some are segmental, some not

Question 4

What is one of the major functions of the mesonephric kidney?

Answer 4

increases amniotic fluid (urine)

Question 5

What is the paramesonephric duct?

Answer 5

an invagination of the nephrogenic chord that parallels the mesonephrict duct

Question 6

What are the characteristics of the metanephric kidney?

Answer 6

• induced to form by an outgrowth of the mesonephric duct
• forms int eh sacral region
• a non-segmented disjunct part of nephrogenic cord
• forms in week 5, tubules form thorugh week 34
• fully functional by week 12

Question 7

What structure grows into the metanephrogenic blastema? What impact do they have on each other

Answer 7

uretary bud; cause induction of metanephrogenic blastema

the metanephorgenic blastema will wrap aroun the uretary bud, causing reciprocal induction

• metanephrogenic blastem: differentiate to kidney tubules
• uretary bud: form drainage tube, completely branch

Question 8

What astructures are formed from the ureteric bud?

What structures are formed from the metanephric blasema?

Answer 8

• ureteric bud
  
  • ureter
  • renal pelvis
  • major calyces
  • minor calyces
  • collecting duct
• metanephric blastema
  
  • distal convoluted tubule
  • loop of henle
  • proximal convoluted tubule
  • bownan’s capsule
  • golmerulus

Question 9

If the purple circle is the gonad, identify the other structures depcted by the diagram

Which duct is kept in female bodies? Which duct is kept in male bodies?

Answer 9

female: keeps paramesonephric
male: keeps mesonephric (reproduction and kidney are physically linked)

Question 10

Which duct is pre-programmed for apoptosis? How can this be blocked?

Answer 10

mesonephric duct pre-programmed fro apoptosis

canb e blocked by presence of testosterone (Leydig cells)

Paramesonephric duct is stable once formed; anti-mullerian factor produced by sertolli cells leads to apoptosis