Development of the Nervous System Flashcards
When does human brain development begin?
3rd week post conception
The intra-uterine environment is important for neurological development. What are some examples of insults here which may be continuous throughout pregnancy?
Alcohol exposure and CMV infection
What is the embryonic period of neurological development?
Conception to 8 weeks
Which part of the embryo becomes us? Which part evolves into the placenta and cord?
Us = epiblast, placenta and cord = hypoblast
What is the first defined neural structure to form? When does this occur?
Neural tube- 20-27 days
What will the hollow centre of the neural tube go on to become?
Ventricular system and the central channel of the spinal cord
What will the anterior/rostral parts of the neural tube go on to become?
Brain
What will the caudal part of the neural tube go on to become?
Spinal cord
If the neural tube does not close at the bottom, what can this result in?
Spina bifida or neural tube defect
High concentration of Pax6 with low concentration of Emx2 induces progenitors to differentiate into what?
Motor neurones
Low concentration of Pax6 with high concentration of Emx2 induces the formation of what neurones?
Visual cortex neurones
What defines the foetal period of neurological development?
9 weeks to term
When is the primary sulci of the brain formed?
Week 8-26
When is the secondary sulci of the brain formed?
Weeks 30-35
When is the tertiary sulci of the brain formed?
36 weeks +
