Detection of cancer progression markers via PCR II Flashcards
1
Q
Transglutaminase 2 (TG2)
A
2
Q
What are the Physiological roles of TG2?
A
- Cell survival and cell death
- Cell adhesion & migration
- Matrix assembly & deposition
- Wound healing
- Angiogenesis
3
Q
What are the Pathological roles of TG2?
A
- Tumour progression
- Coeliac disease
- Neurodegeneration
- Fibrosis (liver, lung, kidney etc.)
- Cystic Fibrosis
- Cardiovascular disease
4
Q
Describe TG2 in Cancer progression
A
5
Q
Describe TG2 in Colorectal Cancer progression
A
TG2 is expressed in human colorectal cancer specimens. TG2 was stained in colorectal cancer tumour sections. A, representative image showing staining in primary colorectal cancers, with arrows indicating tumor (1) and stroma (2). B, TG2 staining at higher magnification in primary colorectal tumour tissue.
6
Q
Diagrams of TG2 in Colorectal Cancer progression
A
7
Q
Describe Epithelial-Mesenchymal Transition (EMT)
and Cancer Stem Cells
A
8
Q
TG2 in Colorectal Cancer progression
A
