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1
Q

alpha-amanitin

A

non competetive inhibitor of RNA pol II - bind to bridge helix and blocks translocation

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2
Q

Rifampicin

A

blocks RNA exit channel of bacterial RNA polymerase

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3
Q

TFIIH clinical syndromes

A

XP
CS
TTD

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4
Q

TFIID

A

Binds TATA box

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5
Q

TFIIH

A

helicase activity and CDK7

Functions in both transcription and DNA repair

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6
Q

Abnormal CD44 splicing –>

A

Cancer

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7
Q

Example of antisense oligo rescue

A

spinal muscular atrophy

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8
Q

Promoter diseases

A

Beta thalassemia
Hemophilia B leyden
Fragile x (trinucleotide repeat)

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9
Q

Craniosynostosis

A

Homeodomain MSX2 - DNA binding domain - binds tighter

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10
Q

Androgen insensivity

A

Zinc finger AR - either AR BD or DNA BD - less

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11
Q

Waardenburg Syndrome

A

bHLH - MITF - melanocyte development and hearing - less

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12
Q

SWI/SNF (use ATP)

A

Disrupt octamers

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13
Q

N- termini histones

A

lysine

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14
Q

Somatic mutations in SWI/SNF genes –>

A

Cancer

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15
Q

Rubinstein Tabi

A

Haploinsufficieny of CBP (a HAT / transcriptional coactivator)

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16
Q

Leukemia and Gene Expression

A

Abnormal fusion proteins - HATS or HDACS with transcriptional regulators –> improper expression

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17
Q

SSBP regulation (5)

A 
ligand
nuclear entry
dna access
phosphorylation
degradation/transcription
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18
Q

How does cyclosporine work?

A

It inhibits calcineurin
Thus, calcineurin can’t de-P NFAT
NFAT nls remain hidden
NFAT can’t go to nucleus to transcribe immune response

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19
Q

Example of regulating TF by amount

A

B-catenin
normally ubiquitinated sent to proteosome
wnt interrupts GSK3 APC/Axin - don’t P B-catenin
build-up
go transcribe

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20
Q

If we mutate APC what happens

A

Colon cancer

too much beta catenin transcribing (with TCF) too many wnt genes

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21
Q

p53 regulated via?

A

the amount

MDM2 targets for destruction and masks activation domain

22
Q

Example of regulation via DNA binding

A

ID proteins and HLH - prevent DNA binding b/c lack basic domain

23
Q

Example of regulation via P

A

CREB - normally bound to DNA but inactive - P results in activation and recruitment of CBP (HAT) –> RNA Pol II

24
Q

4E-BP

A

Sequester EIF4E and block fx

25
mTOR
Phosphorylates 4E-BP - preventing 4E binding EIF4E Enabling translation
26
Rapamycin
Dephosphrylates 4EBP Enabling 4EBP binding EIF4E Disabling translation
27
Interferon
phosphorylates EIF2-alpha | preventing initiation of translation
28
EIF2-alpha necessary for
inition of translation via tRNA met ribosome binding
29
Transferrin
Binds iron
30
Transferrin Receptor
Binds Transferrin/Fe and brings into cell
31
Transferritin
Intracellular Fe holding tank
32
Iron response element
Loop in mRNAs that can bind Iron response element Binding proteins
33
Iron response element binding proteins
bind iron and then bind IRE regulating translation
34
When iron is high what happens with transferritin?
When Iron is high, the IRE-BP cannot bind to the IRE of the mRNA for transferritin and we get increase translation - we need more storage
35
When iron is high what happens with transferrin receptor?
When iron is high, the IRE-BP doe not bind to the IRE of mRNA for transferrin receptor and will decrease translation/ degrade mRNA - we need less
36
Gleevac
Bcr-abl tyrosine kinase inhibitor (CML)
37
Bortezomib
Proteosome inhibitor (Multiple myeloma)
38
Crixivan
HIV protease inhibitor
39
Captopril
ACE inibitor
40
helix breakers
proline and glycine
41
err in posttranslational hydroxylation of proline?
Scurvy (collagen)
42
err in Gly-->Cys mutation in collagen?
Osteogenesis imperfecta
43
HSP40/70
Prevent hydrophobic aggregation
44
Chaperonin
GroES + 2x GroEL --> barrel that helps fold proteins
45
protein disulfide isomerase
rearrange to correct s-s bonds
46
peptide prolyl isomerase
increase rate of conversion or proline to cis
47
Cyclosporin
Prevents calcinuerin from dephosphorylating NFAT - can't move into nucleus to transcribe immune response
48
Puromycin
tRNA mimic | translation terminator
49
Cisplatin
base alkylator
50
acitomycin D and Doxorubicin
Intercalators
51
Etoposide and Captothecin
Topoisomerase targeters

M2M1 (7 decks)

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