Desensitisation NEED TO DO

Question 1

Regulation of Receptors - Private study, seems important

Answer 1

Definition of desensitisation
Definition of tolerance
Definition of supersensitivity
Homologous vs Heterologous desensitisation
Basic processes involved in desensitisation of GPCRs using B1 receptors as example
(modification by phosphorylation, reversible receptor internalisation, down regulation)

Question 2

Define homologous desensitisation

Answer 2

A receptor decreases its response to a s-specific signalling molecule when that agonist is in high concentration

Question 3

Define heterologous desensitisation

Answer 3

Broad unresponsiveness to a variety of other agonists, after prolonged stimulation by one agonist

Question 4

Define tolerance

Answer 4

Reaction to a specific drug and concentration of the drug is progressively reduced, requiring an increase in concentration to achieve the desired effect

Question 5

Define super sensitivity

Answer 5

Reduced concentration of drug needed for same effect