Descending Pathways Flashcards
Identify the main phases of motor learning.
- Voluntary movement (cognitive phase)
- Associative phase of motor learning
- Autonomous phase of motor learning (i.e. If you do movement repetitively, you can learn it and no longer to think about it)
Identify inputs into the corticospinal tract.
Basal ganglia
Cerebellum
Inputs and reflexes from brainstem
Balance from inner ears
Where are potential places that movement starts ?
- Bereitschaftspotential from Association MCx?
- Primary Motor Cx?
- Sensory input?
- Limbic system/basal ganglia?
Describe the structure of a voluntary movement.
- Sensory integration: Target identification; glass of wine needs to be identified as such and its location understood
- Planning; movements required to bring glass of wine to mouth must be ascertained. Relative positions of wine and mouth need to be computed so movement can be planned
- Execution; commands from cortical and brainstem centres need to be ordered and initiated in order to provide the correct strength grip and to smoothly move the glass from the table to the mouth
Each phase involves the involvement of distinct areas of the cerebral cortex as well as feedback from basal ganglia and cerebellum
Define Brodmann areas.
Areas in the brain distinguished by histological structure (presumed to also correspond to differences in function)
Does electrical stimulation of the premotor/SMA produce movement ? Why ?
Electrical stimulation of the area in front of the primary motor area (AKA area 6, contains pre-motor cortex and SMA) also produces movement. However, stronger and more prolonged stimuli are necessary than for the primary motor area.
What are the differences between the movements produced by the primary motor cortex and the pre-motor/SM area ?
Movements produced by premotor/SM areas are usually more complex:
• Can involve more than one joint
• Can be bilateral
What is the effect of destruction of the primary motor cortex on the pre-motor/SM areas ? What does this mean ?
If primary motor area is destroyed, initially electrical stimulation of either premotor areas has no effect
HENCE, their principal actions are mediated through the primary motor cortex (everything goes through that primary motor cortex but the complicated movement patterns are produced in association cortex)
What is the effect of destruction of pre-motor areas ?
• Damage to the premotor areas produces more complex deficits :
Apraxia -cannot perform tasks that involve a complex sequence of movements like brushing one’s hair or drawing a quick sketch (role has been investigated by measuring cerebral blood flow (fMRI))
State which motor areas are stimulated in the following:
- Simple finger flexion
- Sequence of finger movements (actual)
- Sequence of finger movements (mental rehearsal)
- Simple finger flexion: Primary motor cortex and primary somatosensory cortex
- Sequence of finger movements (actual): Primary motor cortex and somatosensory cortex + SMA
- Sequence of finger movements (mental rehearsal): Only SMA
Where does the premotor cortex connect to ?
It projects fibers to:
1. Brainstem motor nuclei
2. Spinal circuits controlling proximal and axial
muscles (mainly postural)
Identify the main roles of the premotor cortex.
The roles of this area are currently being researched and its full function has yet to be described:
1) One function the premotor cortex is thought to be involved in is the plasticity of complex sequences of movements based on prior experience, and is influenced by memory and the limbic system
2) Neurons in this area begin to fire in primates prior to movement, but only when a stimulus requiring movement is detected. Shows an intent to move.
3) It is thought that this area is important in orienting the body in preparation for a voluntary movement
(contributing to establishment of an appropriate postural set)
Distinguish between the location in the brain of the premotor cortex, and the SMA.
“The premotor cortex occupies the part of Brodmann area 6 that lies on the lateral surface of the cerebral hemisphere. The medial extension of area 6, onto the midline surface of the hemisphere, is the site of the supplementary motor area, or SMA.”
Identify the functions of the parietal cortex.
1) Receives signals from a number of sources but is principally involved with spatial processing of visual stimuli. This information can be integrated in the planning of a sequence of motor outputs.
- somatic sensory area (about limb position)
- vestibular system (about head position)
- premotor areas (about motor plans)
- visual system
- limbic cortex (about motivational state)
The motor system as a whole then integrates information from these modalities to focus attention on relevant target and/or upon the spatial relationships of objects of interest
2) Some neurons in this area are context-specific and are only active when the hand is exploring an object of interest
What are the primary spinal motor control routes ?
Corticospinal tracts
How many nerve fibers do the corticospinal tracts contain ? How many of these come from the primary motor cortex ? Where does the remainder come from ?
These contain about 1,000,000 nerve fibres, about 1/3 of which come from the primary Motor cortex.
Most of the remainder come from pre-motor areas and association areas
Describe the path of the corticospinal tracts.
• Corticospinal tract originates from primary motor cortex. Descending fibers form corona radiata and converge to pass through the posterior limb of the internal capsule.
1) Pyramidal or lateral corticospinal pathways: 90% of axons in the corticospinal tract follow the lateral corticospinal tract and decussate at the ventral pyramids in the brainstem, in the medulla, and descend contralaterally, until they terminate on the LMNs in the anterior horn of the spinal cord.
• The axons in the lateral tract are excitatory and control distal muscle (for example digits), for voluntary movements
- but have collateral branches which feed onto the upper motor nuclei in the brainstem (predictive postural set)
• Feed control to the distal muscles contralaterally
• Mainly controlled by cerebral cortex (via the corticospinal tracts)
2) Ventromedial (anterior/medial) pathways: 10% remain ipsilateral until they finally innervate bilaterally at the level of their ventral root. Cross the midline at the level where they terminate on the LMNs.
• Mainly control posture and locomotion
• Feed control to the axial muscles bilaterally (+ proximal muscles)
• Mainly controlled by the brainstem
• Mainly uncrossed
To what extent is the primary motor cortex somatotopically organised ?
- The primary motor cortex is somatotopically organised (there is a body map projected onto it)
- Some areas of the body are represented on the somatotopic homunculus with a disproportionate size.
- This ‘cortical magnification’ reflects the relative ability for precise movement in that part of the body
- Ergo hands and lips and the tongue have a greater representation than the back
- Many complex movements are controlled by just a few cortical neurons who exert their effects on interneurons in the spinal cord which then co- ordinate multiple LMNs
Identify the main inputs to corticospinal output that fine tune movement.
3 Major sources of input:
1) Sensory receptors
-Either direct to primary motor area or indirectly
via the somatic sensory area, the premotor areas or the posterior parietal association cortex
2) From the Cerebellum
- Both planning (feed forward) movement and corrective feedback from proprioception etc.
3) From the Basal Ganglia
- Both initiating complex movement and correction from the reward system. Overlay of emotional component from limbic circuits.
All movement-related inputs to the cortex coming from other parts of the brain and spinal cord also pass though the Thalamus
Other sources (help to modulate motor system):
- Vestibulospinal pathway (postural stability)
- Reticulospinal pathway (postural adjustments, muscle tone)
Distinguish between UMNs, LMNs, and interneurons.
UMNs orchestrate complex directed movements. UMN cell bodies are in brain or brainstem and do not project outside the CNS
LMNs are for single muscle innervation. LMN cell bodies in the ventral horn of spinal cord or motor nuclei of the brainstem, and project outside the CNS to muscle.
Interneurons coordinate groups of muscles
Draw each of the main four spinal pathways.
Refer to slide 18 in lecture “Descending Pathways”
What is the cause of the following:
- wasting of interossei
- wasting of thenar eminence
- hypertrophy calves
- bilateral wasting of anterior compartment of legs
- wasting of interossei: ulnar nerve compression (possibly at elbow)
- wasting of thenar eminence: median nerve compression
- hypertrophy calves: some muscle dystrophies (e.g. Duchenne’s)
- bilateral wasting of anterior compartment of legs: compression of fibular head (possibly due to tight boots), leading to compression of lateral popliteal nerve, causing wasting of tibialis anterior, and possible foot drop
Define posture. Why is it important ?
- Posture is the position of a body and its parts relative to each other
- Vitally important in balance
Which pathway is mainly responsible for posture ?
Ventromedial pathways
