Descending Modulation Of Pain Flashcards

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1
Q

What is neurogenic inflammation?

A
  • normal transmission of the sensation/anticipation of pain through nociceptors from PNS to CNS
  • normal inflammatory action
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2
Q

What is peripheral sensitisation?

A
  • a reduction in the threshold of receptor sensitivity
  • an increase in the magnitude of responsiveness from nociceptors
  • results in allodynia
  • heat sensitivity, but not mechanical
  • requires ongoing stimulation to lower activation threshold and increase responsiveness of nociceptors
  • requires ongoing peripheral pathology for sensitisation to be maintained
  • localised to site of injury
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3
Q

What is central sensitisation?

A
  • increased responsiveness of nociceptors in the central nervous system to either normal or sub-threshold stimulus
  • hypersensitivity to stimuli
  • response to non-noxious stimuli
  • increased pain response evoked by stimuli outside of the injury (expanded receptive field)
  • a-beta mechanoreceptors become involved => hypersensitivity in non-inflamed tissue
  • sensitive to touch
  • non-mechanical/non-anatomical pattern of pain provocation in response to movement
  • diffuse
  • psychological factors involved
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4
Q

What is the result of central sensitisation?

A
  • recruitment of additional, sub threshold nociceptors => increased field of receptivity
  • increased output of Nociception
  • effects persist beyond tissue healing => allodynia
  • over-activation of ascending pathway and under-activation of inhibiting pathways
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5
Q

How does central sensitisation occur?

A
  • inputs = C fibres + a-beta mechanical fibres (don’t usually get involved)
  • C fibres release substance P, CGDP to dorsal horn
  • a-beta fibres release glutamate (excitatory) to dorsal horn
  • under normal circumstances NMDA is blocked, however, sustained release by nociceptors of glutamate, substance P and CGDP forces Mg2+ from NMDA receptor (unblocking)
  • this boosts synaptic efficacy and allows Ca2+ into the dorsal horn neurons => activates Intracellular pathways to CNS => maintaining central sensitisation
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6
Q

What is the role of glial cells (Astrocytes) in normal neuronal transmission?

A
  • Astrocytes take part in glutamate (excitatory) and GABA (inhibitory) reuptake
  • Astrocytes are activated by neurotransmitters
  • Once activated Astrocytes experience an increase in Ca2+ and release transmitters of their own; enhancing or inhibiting synaptic activity
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7
Q

What is the role of glial cells (Astrocytes) in central sensitisation?

A
  • Astrocytes become activated and upregulate neuronal transmission => less re-uptake of glutamate (excitatory), more re-uptake of GABA (inhibitory)
  • works with microglia which release chemicals to increase/decrease re-uptake
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8
Q

What is the physiology of the pain-gate mechanism?

A
  • located in dorsal horn of spinal cord (Substantia gelatinousa SG)
  • primary neurons:

—> a-beta = quick + non-noxious => light touch, pressure, hair movement

—> a-delta = slower + noxious => pain + temperature => sharp, intense, tingling sensations

—> C fibres => very slow => pain + temperature + chemical => prolonged burning sensations

  • if interneurons (inhibitory) in SG stimulated by a-delta + C fibres => excitatory response => pain modulated
  • activation of large diameter a-beta fibres can reduce and inhibit transmission of small diameter a-delta and c-fibres (pain gating)
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9
Q

How do a delta fibers inhibit activation of c (pain) fibres in pain gating?

A
  • c-fibbers are slow, caring pain signals in 1st order neuron => excitatory stimulates 2nd order neuron and switches off interneuron
  • if a-delta fibers are activated using mechanical pressure or temperature => activates interneuron stopping transmission of pain signals
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10
Q

How is pain gating relevant to treatment?

A
  • adding pressure
  • cold/heat
  • TENs => delivers small electrical current to activate non-nociceptive receptors in skin => signal to interneuron in spinal cord then activated to inhibit pain signals
  • brain sends endorphins to the pain gate => lower transmission of pain signals between 1st and 2nd order neuron (prevents substance P release + inhibits synaptic potentials in post synaptic neurons) + reduced pain perception in brain
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11
Q

What can create endorphins?

A
  • pleasurable activities
  • excitement
  • meditation
  • laughter
  • intense exercise
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12
Q

What is descending pain modulation?

A
  • a delta/c nociceptive input into dorsal horn
  • goes to medulla (rostral ventro-medial medulla RVM or dorsolateral pontine segment)
  • into midbrain via periaqueductal gray (PAG)
  • into thalamus + cortex + insula + amygdala + hypothalamus
  • descending pathways go via PAG (midbrain)
  • medulla (RVM)
  • down to spinal segment and where 1st order neuron meets 2nd order neuron; serotonin + noradrenaline released => opioids released into interneuron resulting in inhibition of Spinothalamic fibers of pain
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13
Q

What is Diffuse Noxious Inhibitory Control (DNICS)?

A
  • 2 noxious stimulants
  • 1st is inhibited by descending modulation to that segment of the spine e.g. lumbar decreasing stimulation of nociception
  • 2nd noxious stimulant is facilitated by descending modulation to that segment of the spine e.g. cervical increasing stimulation of nociception
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14
Q

What is another name for DNIC (diffuse noxious inhibitory control)?

A
  • lateral inhibition
  • listen to a specific sound and see how other sounds reduce
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15
Q

What is disinhibition?

A
  • failure of normal descending pain inhibitory system
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16
Q

What is a major factor in heightened pain response?

A
  • DNIC - descending noxious inhibitory control
17
Q

What occurs simultaneously with central sensitisation?

A
  • DNIC (descending noxious inhibitory control)
  • not synonymous
18
Q

How does DNIC (descending noxious inhibitory control) present?

A
  • can be local, bilateral, segmental or whole body
  • linked to fibromyalgia, RA, chronic pain
19
Q

How is DNIC (descending noxious inhibitory control) tested?

A
  • can be tested with QST (quantitative sensory testing)
20
Q

Pain can be modulated in 2 ways

A
  • descending facilitation
  • descending inhibition (endogenous analgesia)
21
Q

What are the psychosocial factors affecting pain experience by modulation?

A
  • context => pain beliefs/expection/placebo
  • cognitive set => hypervigilance/attention/distraction/catastrophising
  • chemical + structural => neurodegeneration/metabolic e.g. opiodergic, dopaminergic/maladaptive plasticity
  • mood => depression/anxiety/catastrophising
22
Q

Which pathways are mainly serotonergic?

A
  • pro-nociceptive pathways
23
Q

Which pathways are mainly noradrenergic?

A
  • anti-nociceptive pathways
24
Q

Which brain areas are involved with the modulation of pain?

A
  • periaquaductal grey (PAG)
  • rostroventral medulla (RVM)
25
Q

How do descending pathways bring change in the dorsal horn?

A
  • release of serotonin and noradrenaline into interneuron which either inhibits or facilitates
  • serotonin facilitates in DNIC
  • noradrenaline inhibits in DNIC
26
Q

What happens to the ascending input from nociceptors?

A
  • a beta fibres become stimulated and transmit mechanical nociceptive signals when they wouldn’t usually
27
Q

What factors produce either a descending facilitation or inhibition of nociception?

A
  • mechanical stimulation e.g. pain gating
  • descending inhibition from nociceptive stimulation to the brain
28
Q

What is DNICS?

A

Descending noxious inhibitory control

29
Q

When might we use DNICS in practice

A
  • if a patient has an primary and secondary injury, know that the primary injury is being inhibited by noradrenaline and secondary injury is being stimulated by serotonin
30
Q

What are the clinical implications of disinhibition?

A
  • a patient can experience 2 injuries, the first one might disappear when the second one gets more intense