Dermatopathology Flashcards
acantholysis
detachment of epidermal cells, particularly those of the stratum spinosum from one another due to breakdown of intercellular bridges, resulting in the formation of intraepidermal vesicles
acantholytic cells/acanthocytes
detached cells within vesicles
acanthosis
increased thickness of stratum spinosum due to hyperplasia (true acanthosis) or hypertrophy (pseudoacanthosis)
alopecia
loss of hair
apoptosis
the process of an individual cell death characterized by rounded, individualized brightly eosinophilic keratinocytes; present at all levels of the epidermis
apoptotic body/civatte body/colloid body/hyaline body
a round eosinophilic cellular extrusion formed by degenerating basal cells dropped off in the lower epidermis or upper dermis
atopy
a hypersensitivity state subject to hereditary influences
ballooning degeneration
refers to a specific degenerative change in epidermal cells characterized by swollen, pale eosinophilic cytoplasm with intracellular edema and without vacuolation
calcinosis
abnormal deposits of calcium in tissue
callus
exaggerated hyperkeratosis in a localized area, especially over pressure joints
comedones
accumulation of keratin and dried sebum in a dilated pilosebaceous orifices
crust
dried exudates on the skin surface, composed of secretion with or without bacterial or epithelial debris
dysplasia
an abnormality in cell maturation process and morphology or the relationship between cells in epithelial structures; loss of normal stratification of the epidermis has the connotation of possible progression to neoplasia
epidermal collarette
flat to minimally elevated ring of scale that enlarges peripherally
epidermolysis
separation of the epidermis and dermis with the formation of subepidermal clefts and blisters
eruption
a rapid development of primary lesions of the skin
erythema
redness produced by capillary dilation and congestion
excoriation
superficial linear erosion or ulcer caused by scratching and rubbing