Dermatopathology Flashcards

1
Q

acantholysis

A

detachment of epidermal cells, particularly those of the stratum spinosum from one another due to breakdown of intercellular bridges, resulting in the formation of intraepidermal vesicles

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2
Q

acantholytic cells/acanthocytes

A

detached cells within vesicles

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3
Q

acanthosis

A

increased thickness of stratum spinosum due to hyperplasia (true acanthosis) or hypertrophy (pseudoacanthosis)

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4
Q

alopecia

A

loss of hair

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5
Q

apoptosis

A

the process of an individual cell death characterized by rounded, individualized brightly eosinophilic keratinocytes; present at all levels of the epidermis

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6
Q

apoptotic body/civatte body/colloid body/hyaline body

A

a round eosinophilic cellular extrusion formed by degenerating basal cells dropped off in the lower epidermis or upper dermis

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7
Q

atopy

A

a hypersensitivity state subject to hereditary influences

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8
Q

ballooning degeneration

A

refers to a specific degenerative change in epidermal cells characterized by swollen, pale eosinophilic cytoplasm with intracellular edema and without vacuolation

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9
Q

calcinosis

A

abnormal deposits of calcium in tissue

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10
Q

callus

A

exaggerated hyperkeratosis in a localized area, especially over pressure joints

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11
Q

comedones

A

accumulation of keratin and dried sebum in a dilated pilosebaceous orifices

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12
Q

crust

A

dried exudates on the skin surface, composed of secretion with or without bacterial or epithelial debris

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13
Q

dysplasia

A

an abnormality in cell maturation process and morphology or the relationship between cells in epithelial structures; loss of normal stratification of the epidermis has the connotation of possible progression to neoplasia

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14
Q

epidermal collarette

A

flat to minimally elevated ring of scale that enlarges peripherally

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15
Q

epidermolysis

A

separation of the epidermis and dermis with the formation of subepidermal clefts and blisters

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16
Q

eruption

A

a rapid development of primary lesions of the skin

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17
Q

erythema

A

redness produced by capillary dilation and congestion

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18
Q

excoriation

A

superficial linear erosion or ulcer caused by scratching and rubbing

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19
Q

exocytosis

A

migration of inflammatory cells and/or erythrocytes through the intercellular spaces of epidermis

20
Q

exophytic

A

growing outward from the skin surface

21
Q

endophytic

A

growing inward from the skin surface

22
Q

fissure

A

deep linear defect from the epidermis to the dermis

23
Q

folliculitis

A

inflammation of the hair follicles

24
Q

furuncle

A

follicular abscesses, “boil”, ruptured folliculitis

25
Q

hyperkeratosis

A

thickening of the stratum corneum due to an increased number of keratinized cells

26
Q

orthokeratosis

A

a form of hyperkeratosis where the nuclei are lost

27
Q

hypertrichosis

A

presence of more than normal amount of hair

28
Q

hypotrichosis

A

presence of less than normal amount of hair

29
Q

licehnification

A

thickening of skin with exaggeration of normal markings; consists of acanthosis, hyperkeratosis, and dermal fibrosis

30
Q

licehnoid

A

grossly refers to flat-topped papules; microscopically refers to a horizontal; dense band-like infiltrate of mononuclear cells in the papillary dermis obscuring the dermo-epidermal junction

31
Q

macule

A

a flat circumscribed, alteration in skin color or texture; may be pale, hyperpigmented or erythamatous

32
Q

nodule

A

a large papule over 1 cm; a circumscribed domed lesion raised above the level of the epidermis; often extends into the dermis

33
Q

papule

A

circrumscribed palpable elevation of skin less than 1 cm in diameter, usually due to cellular infiltration or proliferation, inflammatory or neoplastic

34
Q

parakeratosis

A

subset of hyperkeratosis with retention of nuclei in keratinized cells

35
Q

patch

A

macule greater than 2 cm in diameter

36
Q

plaque

A

flat-topped nodule

37
Q

pustule

A

small circumscribed epidermal or dermal accumulation of purulent exudate

38
Q

pyoderma

A

purulent dermatitis

39
Q

scab

A

common word for crust

40
Q

seborrhea

A

a functional disturbance of sebaceous glands or of lipid metabolism of the epidermis; accompanied by abnormal keratinization process

41
Q

spongiosis

A

widening of intercellular spaces due to intercellular epidermal edema

42
Q

tumor

A

usually, not always, neoplastic nodule

43
Q

vesicle

A

a small circumscribed elevation of epidermis caused by accumulation of clear fluid within or beneath the epidermis

44
Q

bulla

A

a large intraepidermal or subepidermal vesicle; over 5 mm in diameter

45
Q

wheal

A

sharply circumscribed skin elevation produced by edema of the superficial dermis