Dermatopathology Flashcards
What are the layers of the skin?
Epidermis - purple, keratinocytes, 5-10 cell layers thick
Dermis - adnexal structures, hair follicles, sebaceous glands, blood vessels, nerves
Subcutaneous
Name the 6 types of inflammatory reactions.
Vesiculobullous Spongifotic Psoriasiform Vasculitic Lichenoid Granulomatous
Name three vesiculobullous conditions and brief features
Bullous pemphigoid - often seen in elderly requiring admission.
- flexural surfaces-
accumulation of fluid between epidermis and dermis
- infiltrate contains eosinophils - release elastases that destroy anchoring filaments
- IgG and c3 attacking dermoepidermal junction - destroys anchoring filaments
Pemphigus vulgaris
destroys adhesion molecules which keep keratinocytes - free floating in the epidermis
Pemphigus foliaceus very rare antigen desmoglian - keeps keratinocytes stratum corneum destroyed - subcorneal blisters shows inflammatory infiltrate
Name a spongiform condition
Discoid eczema
Name a psorisiform condition
psoriasis
- presents on extensor surfaces
Name some lichenoid conditions
Lichen planus
Erythema multiforme
Lupus Erythematosus
Pityriasis rosea
What is the most common neoplastic condition?
Seborrhoeic Keratosis
What is the commonest cancer in the western world?
BCC
