Dermatology pharmacology

Question 1

What are the vehicle options for admistrating dermatologic drugs?

Answer 1

Ointment

Cream

Gel

Lotion

Solution

Paste

Powder

Question 2

Is penetration of a topical medication on the skin below greater, lesser or equal to non-disease skin

Answer 2

It would be greater because the skin barrier is not intact

Question 3

Bactroban

Derived from?

Mechanism?

Use?

Answer 3

Mupirocin ointment

It is derived from Pseudomonas, reversibly binds bacterial isoleucyl transfer RNA synthetase

Use: Staph (MRSA), strep and some gram negatives

Question 4

Neomycin

Answer 4

This is an aminoglycoside

Binds to the 30S subunit of ribosome

Use: gram positive and negative

It causes a Type 4 hypersensitivity reaction resulting in contact dermatitis

Question 5

Bacitracin

Answer 5

Use: gram positive bacteria

Can cause a type 4 hypersensitivity reaction resulting in contact dermatitis

Question 6

Polymyxin B

AE?

Answer 6

Peptide antibiotic

Use: gram negatives

AE: nephrotoxic neurotoxic