dermatology (in depth) Flashcards
(38 cards)
dermatitis
- main three types? (+ causes)
- presentation?
- treatment?
- atopic dermatitis (eczema)
- allergic contact dermatitis
(both autoimmune) - irritant contact dermatitis
(caused by over exposure to water, cold, certain chemicals)
red, itchy, scaly patches (norm on inside of joints) with accompanying scarring
- topical steroids if autoimmune
- remove irritants/moisturise
nb autoimmune often occurs in ‘flare ups’
psoriasis
- what is it?
- presentation?
- treatment?
autoimmune condition which results in over production of skin cells
-> scaly patches on extensor surfaces
- normally small patches but can be larger and can also effect joints (psoriatic arthritis)
topical steroids and vit D treatment
- if bad, us UV treatment
nb sun is good as damages skin cells!
nb affects around 2% of people, men = women
acne vulgaris
- what is it?
- presentation?
- treatment?
inflammatory disease of hair follicle
- androgen makes worse
varying lesions on face, chest + top of back
mild:
- open + closed comedones (black + white heads)
moderate:
- above PLUS inflammatory lesions (papules, pustules, nodules + cysts)
severe:
- above but worse/more lesions
treatment depends on severity:
- topical therapies (benzoyl peroxide, Abx, retinoids)
- oral therapies (anti-androgens, Abx, retinoids)
nb vulgaris means common
Rosacea:
- what is it?
- presentation?
- treatment?
poorly understood condition
- flushing
- persistent facial redness
- visible blood vessels
- papules + pustules
- thickened skin
often worse on nose, cheeks, forehead + chin
nb sunlight makes it worse
- topical metronidazole
- topical azelaic acid
urticaria:
- pathogenesis?
- causes? 4
- treatments? 2
a trigger causes high levels of histamine to be released in the skin -> leakage from blood vessels -> red, swollen pathes which are itchy
nb looks like a severe nettle rash
- allergic reaction (eg to food or insect bite/sting)
- cold or heat exposure
- infection (eg common cold)
- some drugs (eg NSAIDs, Abx)
nb complication of severe urticaria is angioedema +/or anaphylaxis
lichen planus:
- what is it?
- what does it look like?
- treatment? 2
- prognosis?
a chronic inflammatory skin condition affecting skin +/or mucosal surfaces
- several different types
- cutaneous lesions look a bit like psoriasis but less white scale and are often itchy
- mucosal lesions (most often in mouth) often begin as painless white streaks but can become painful and more ulcer-like
- lesions on nails cause thinning and ridging of nails + nails may stop growing
nb are other variants but 3 above are most common
- topical (or oral) steroids
- if severe, can use drugs such as methotrexate
nb treatment is not needed for mild cases which are often self-limiting
nb can lead to cancer dt chronic inflammation
- tends to clear within a couple of years in most people but mucosal lichen planus persists longer (eg around a decade)
- spontaneous recovery is unpredictable + may suffer recurrence
impetigo:
- appearance?
- causative organisms? 2
- how enter skin?
- other risk factors? 2
itchy red sores that eventually crust over before healing with a red patch
- often itchy
- staph aureus
- strep pyogenes
through:
- cut
- insect bite
- eczema
- diabetes
- immunocompromised (HIV, on chemo)
nb very contagious
nb normally found around nose + mouth but can affect other sites too
impetigo:
- non-pharm management? 2
- pharm management? 1
- don’t itch/scratch
- avoid close ocntact w others (esp kids)
- topical Abx (oral if v bad, fever etc)
cellulitis and erysipelas:
- what’s the difference?
- norm causative organisms? 2
- who’s at risk? 11
erypsiela = infection of upper dermis + sub cut lymphatics
cellulitis = infection of lower dermis + subcut tissue
nb often occur together
- strep pyogenes (group A strep) - 2/3rds
- staph aureus - 1/3rd
nb strep pyogenes causes almost all erysipelas
- previous episode of erysipelas/cellulitis
- underlying skin condition (athletes foot, tinea pedis, cracked heels)
- venous disease +/or lymphoedema
- injury/trauma (incl radiation)
- immunodeficiency
- immunosuppressive meds
- diabetes
- CKD
- chronic liver disease/alcoholism
- obesity
- pregnancy
nb young and elderly most at risk pops
cellulitis + erysipelas:
- clinical presentation?
- where on body norm affected?
- treatment?
very sharp raised border (in erysipelas)
bright red, firm and swollen
(dimpled skin - peus d’orange)
painful and warm
can be blistering and necrotic
can have fever
norm on legs but can be anywhere
- wound care/dressings
- elevation of leg
Abx - norm penicillin based
cellulitis:
- differential diagnoses? 10
- eczema/dermatitis
- psoriasis
- thrombophlebitis
- fungal infection (eg tinea corporis)
- drug reaction
- insect bites/stings
- radiation damage (eg radiotherapy)
- inflammatory breast cancer
- lipodermatosclerosis
- DVT
folliculitis:
- cause?
- 2 commonest causative organisms?
- where found on body?
inflammation of hair follicles
can be due to infection, occlusion + various skin diseases
norm staph aureus in bacterial folliculitis
(nb pseudomonas aeruginosa infects people in hot tubs if inadequately chlorinated)
norm:
- chest, back, buttocks, arms, legs or face
- ie anywhere there’s hair
tender red spots, often with a surface pustule
nb acne is also a form of folliculitis
trestment depends on cause
intertrigo:
- what is it?
- where does it affect?
- risk factors? 3
an inflammatory rash in the flexures or body folds
nb can get superficial infection on top of
- overweight
- genetic tendency to skin disease
- hyperhydrosis (incl dt hot/humid climate)
difference between chicken pox and shingles:
- transmission
- signs/symptoms
- distribution of rash
- character of rash
chicken pox:
- respiratory secretions + vesicular fluid
- – malaise, fever, rash
- truck initially, progressing to face + extremities
- non-grouped, itchy vesicles
shingles:
- reactivation of VZV in nerve root
- – dermatological rash, neuralgia, weakness of affected nerve, malaise, fever
- a nerve root distribution, often on trunk or branch of trigeminal
- grouped, markedly erythematous, painful vesicles
Herpes simplex:
- two types? where do they infect?
- mechanism of reactivation?
- common triggers? 4
- treatment?
Herpes simplex type 1 - mouth
Herpes simplex type 2 - genitals
- virus stays active in nerve root and is then reactivated to form a blistering spot, often in the same place
- other infections (e.g. cold or flu)
- sunlight on the area
- generally getting run down
- a skin injury at the sight of recurrence
- antiviral tablets (take as soon as notice it’s coming +/- antiviral cream
HIV
- pathogenesis?
- high risk groups? 4
- initial symptoms?
Virus binds to CD4 receptors on helper T cells and then replicate inside the cell before bursting out to bind to other helper T cells
- sex workers
- MSM
- black African heterosexuals
- IVDU
1-2 week flu-like illness
- fever
- sore throat
- body rash
- fatigue
- joint pain
nb then can be a latent period varying from a month to over 10 years with no symptoms
HIV:
- definition of AIDS?
- list some of the conditions?
1) infected with HIV virus
AND
2a) a CD4+ T-cell count below 200 cells/uL
OR
2b) has one of the aids-defining conditions
- candidiasis of oesophagus/trachea/lungs (nb not mouth)
- cervical cancer (invasive)
- cytomegalovirus
- encephalopathy (HIV-related)
- chronic herpes simplex (ulcer for >month)
- Kaposi’s sarcoma
- certain types of lymphoma
- TB (any)
- toxoplasmosis of brain
- wasting syndrome (due to TB)
nb there are about 30 conditions in all!
HIV
- two types of prophylaxis?
- two monitoring blood tests?
- treatment
- PEP (post-exposure prophylaxis)
- PrEP (pre-exposure prophylaxis)
- HIV viral load (conc of virus in blood)
- CD4 count (affect of virus on immune system
HAART
viral warts:
- virus cause?
- what are they?
- group most commonly affected?
- possible complication?
- treatments?
human papilloma virus (HPV)
hyperkeratotic papules
children
HPV 16 + 18 infection around genitals can lead to cervical or penile carcinoma
- paints/gels of salicylic acid
- occlusion with duct tape
- cryotherapy
- regular paring with a scalpel
molluscum contageosum:
- what is it?
- who gets it?
- what it looks like?
- management?
Viral infection that affects skin
- mainly children
- immunosuppressed (HIV, chemo)
The spots are usually firm and dome-shaped, with a small dimple in the middle. They’re usually less than 5mm (0.5cm) across, but can sometimes be bigger.
They’re typically pink or red, although they may have a tiny white or yellow head in the centre. If this head ruptures (splits), a thick yellowy-white substance will be released, which is highly infectious.
Normally self limiting
Treat if immunosuppresed or particularly unsightly in adults
Tinea: - causative organism? Name if infects: - beard - head - body - groin - foot - nail
Treatment?
- dermatophyte fungus
- beard - tinea barbae
- head - tinea capitis
- body - tinea corporis (ringworm)
- groin - tinea cruris (jock itch)
- foot - tinea pedis (athletes foot)
- nail - tinea unguium
Topical antifungals (systemic for barbae, capitis + unguium as doesn’t penetrate hair or nails)
Keep area dry!!
genital candida:
- who’s at risk? 3
- symptoms in women?
- symptoms in men?
- treatment? 3
- pregnant + breastfeeding women
- diabetes
- poor immune system
- white discharge (like cottage cheese, nb not usually smelly)
- vaginal itching/irritation
- soreness & stinging during sex or when peeing
- irritation, burning + redness around head of penis
- white discharge (like cottage cheese)
- unpleasant smell
- difficulty pulling back foreskin
- oral antifungals
- antifungal creams
- pessary (pills in vag)
oral candida:
- risk factors? 5
- symptoms/signs? 4
- treatment? 2
- prevention? 1
- chemo/radiotherapy
- on corticosteroids (incl inhalers) or wide-spec Abx
- wear dentures
- have diabetes
- have HIV (can spread to oesophagus)
- white/yellow patches on tongue, lips, gums, roof of mouth + inner cheeks
- redness + soreness in mouth + throat
- cracking at corners of mouth
- pain when swallowing
- antifungal gels
- oral antifungals
- chlohexadine mouthwash if at risk/poor immune system
Pityriasis versicolor:
- what is it?
- what does it look/feel like?
- risk factors? 2
- treatment?
yeast infection of the skin
- scaly patches of hypo or hyper pigmented skin on trunk, neck +/or arms
can be itchy or not
- young adults
- hot, humid climates (summer, sweating)
- topical antifungals