Dermatology Glossary of Terms Flashcards

1
Q

abscess

A

a pus-containing skin infection that occurs from bacteria or parasites

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2
Q

acanthosis

A

involves thickening of the skin, which results in papules and plaques forming

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3
Q

acanthosis nigricans

A

a breakout of hyperpigmented plaques and warty papules in the axillae, groin, neck/ and or anogenital region

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4
Q

acne

A

a skin condition characterized by blackheads, pimple outbreaks, cysts, infected abscesses, and scarring that is most commonly found on the face, back, shoulders, and chest

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5
Q

acne conglobata

A

severe acne; also called cystic acne; the acne is chronic and will produce intense cysts that go deep into the skin

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6
Q

acne keloid

A

a disorder where a secondary infection will develop in scarring; the pustules that form will be deep in intensity and can occur on the scalp and rear part of the neck

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7
Q

acne vulgaris

A

a skin condition resulting in whiteheads, blackheads, and inflamed red pimples

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8
Q

acitinic purpura

A

a skin condition that results from chronic sun-exposure and increasing age

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9
Q

acrochordon

A

a small skin tag that can be located almost anywhere on the body or face

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10
Q

acrodermatitis

A

inflammation in the skin in the hands and feet; this may be caused by a parasite; is a possible sign on Lyme disease

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11
Q

actinomycosis

A

a bacterial disease that is caused by the Actinomyces species; this is an infection that can produce abscesses in the body

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12
Q

adenocarcinoma

A

cancer that starts in the body’s glands and will transfer to other parts of the body

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13
Q

albinism

A

a skin defect that result in little or no color pigment in the skin, hair and eyes

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14
Q

algid

A

cold skin associated with malaria

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15
Q

actinic keratosis

A

a pre-cancerous patch of skin; the scaly of thick skin will develop due to the body being exposed to the sun’s rays for a lengthy period of time

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16
Q

aloe

A

a juice that comes from the aloe plant leaf; the juice may be dried and prepared in an ointment

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17
Q

alopecia

A

a condition where the immune system attacks the scalp’s hair follicles

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18
Q

anetiderma

A

a benign form of dermatosis that is triggered by a loss of dermal elastic tissue

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19
Q

angioedema

A

swelling beneath the skin rather than on the surface of the skin

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20
Q

angiokeratoma

A

a benign lesion of capillaries; the condition results in several red and blue marks on the skin

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21
Q

angioma

A

a benign tumor that includes blood vessels and lymph nodes; the vessels can cause some redness and other spots on the skin and may trigger pains depending on how intense the tumor is

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22
Q

angiomyoma

A

a benign smooth muscle tumor; the condition develops in the vessel walls in the body

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23
Q

antiperspirant

A

a compound that is applied topically to prevent or reduce sweating

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24
Q

antipruritic

A

an agent that controls itching

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25
Q

apocrine glands

A

sweat glands that can be found n the hairiest areas of the body

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26
Q

argyria

A

a condition that develops due to excess exposure to silver dust or the silver element; the condition will cause the skin to develop a purple or purple-grey tint

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27
Q

atopic dermatitis

A

also called eczema; a chronic skin condition that cause scaly and itchy rashes

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28
Q

atrophy

A

thinning of the skin due to reduction of underlying tissue

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29
Q

barrier cream

A

a cream that will be applied to the skin to prevent the tissue from allergens and other threats

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30
Q

basal cell carcinoma

A

the most common, slow-growing form of skin cancer where small bumps form on the skin and may bleed; a malignant form of skin cancer that develops due to frequent exposure to the sun

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31
Q

bioposy

A

a surgical procedure performed by a dermatologist or surgeon that involves the removal and examination of tissues or cells from the body

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32
Q

birthmark

A

a benign spot that appears at birth; the spot appears due to blood vessels growing more than needed

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33
Q

blackhead

A

a small bit of fatty material that develops in the sebaceous gland in the skin; may be found in a clogged hair follicle

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34
Q

blemish

A

also referred to as acne

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35
Q

blepheroplasty

A

also called eye lid rejuvenation

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36
Q

blister

A

a growth of watery fluid

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37
Q

boil

A

a tender spot on the skin that is associated with acne; the area may develop inflammation and can also include pus

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38
Q

botox

A

a cosmetic injection to temporarily diminish or remove frown lines, forehead creases; and crows feet near the eye

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39
Q

bruise

A

a type of contusion that appears on the skin due to a form of trauma

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40
Q

bulla

A

a skin blister that is raised more than .5 cm that contains serious fluid above the dermis

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41
Q

bullous pemphigoid

A

a skin disorder producing large blisters

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42
Q

burn

A

an injury that is produced due to outside material; can be triggered by extreme heat or cold conditions, exposure to chemicals, electricity, radiation, or uv light

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43
Q

cafe au lait spot

A

pigmented birthmarks that are uniform light to dark brown colors and are usually oval in shape; presented at birth

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44
Q

calamine

A

a medicated lotion compound; the material is applied to the skin to dry out areas that may be irritated

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45
Q

candidiasis

A

also called yeast infection and is a fungus skin infection occurring in the mouth, skin folds, navel, genitals, and nail beds

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46
Q

capillary hemangioma

A

also known as a strawberry birthmark; the benign tumor develops due to a series of capillaries growing more than normal

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47
Q

carbuncle

A

an acute, round, firm, tender boil on the skin

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48
Q

cavernous hemangioma

A

a raised, red to purple sore on the skin due to a buildup of blood vessels

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49
Q

cellulitis

A

a common deep skin infection caused by bacteria resulting in localized area inflammation

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50
Q

chafing

A

irritation to the skin that is triggered by a surface rubbing on the area

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51
Q

chancre

A

a syphilis sore

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52
Q

chancroid

A

a bacterial disease that is transmitted through sexual contact; also called a venereal ulcer

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53
Q

chapping

A

a process where the skin starts to become dry and cracked

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54
Q

chemical peel

A

a solution used to improve the texture of the face by removing the top layer of the skin to help minimize the appearance of sun damaged skin, irregular pigment, and scars

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55
Q

cherry angioma

A

a small red to purple papules on the skin containing abnormal proliferation of blood vessels

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56
Q

chigger

A

also known as a berry bug; a red tinted arachnid that can transfer a skin rash

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57
Q

chloasma

A

a condition where brown patches start to develop on the face; patches are benign and may be triggered by hormonal changes or from excess sun exposure

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58
Q

cicatrix

A

a scar that appears on the skin after a wound heals

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59
Q

clavus

A

also known as corn and heloma; is a condition which results in the thickening of the skin

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60
Q

closed comedo

A

also called a whitehead; a type of acne with a white or yellowish head on the skin

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61
Q

cold sore

A

a recurrent lesion around the mouth caused by herpes simplex virus

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62
Q

collagen

A

a natural protein found in bone, skin, ligaments, and tendons

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63
Q

collagen injections

A

a cosmetic injection beneath the skin to replace the body’s natural collagen to treat minor imperfections on the face such as wrinkles, scares, and facial lines

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64
Q

comedo

A

another words for a blackhead or clogged hair follicle

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65
Q

complexion

A

the general appearance of one’s facial skin

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66
Q

contact dermatitis

A

a rash of inflammation of the skin caused by having contact with various substances

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67
Q

contusion

A

an injury triggered by a blow to the body that will not break the skin

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68
Q

creeping eruption

A

a skin infection that causes severe itching

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69
Q

crusting

A

also known as a scab; dried blood, pus, or other fluids on the surface of the skin

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70
Q

cryosurgery

A

a dermatological procedure, performed by a dermatologist or skin care professional, done by freezing the lesion with liquid nitrogen

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71
Q

cyst

A

a deep lesion filled with pus or fluids

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72
Q

cystic acne

A

a severe form of acne forming papule

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73
Q

dander

A

a material that the body sheds

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74
Q

dandruff

A

shedding of scaly and dry skin cells from the scalp

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75
Q

debridement

A

the removal of damaged tissue from a wound

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76
Q

DEET

A

diethyltoluamide; an oily compound that works as an insect repellent

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77
Q

deoderant

A

a prominent type of antiperspirant

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78
Q

dermatitis

A

inflammation in the skin

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79
Q

dermabrasion

A

a dermatological procedure to remove acne scars or the like by abrading

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80
Q

dermatofibroma

A

a small, non-cancerous red or brown bump in the skin normally found on the legs

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81
Q

dermatographism

A

a skin condition where raised, reddish marks or hives appear on the skin due to light scratching

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82
Q

dermis

A

the middle layer of the skin consisting of the blood vessels, hair follicles, and sweat glands

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83
Q

desmosome

A

a structure in the body that includes two adjacent cells that connect to each other

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84
Q

desquamation

A

the peeling or shedding of the epidermis

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85
Q

diaper rash

A

a concern that may develop in babies and infants

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86
Q

diaphoresis

A

sweating

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87
Q

dimple sign

A

a central depression or dimple educed within a lesion when it is squeezed

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88
Q

discoid/ discoid lupus

A

a descriptive term used for round papules, plaques, or patch resembling a disk-like shape

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89
Q

drug eruption

A

an eruption caused by injection, ingestion, inhalation, or insertion of a drug

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90
Q

dysplasic nevus

A

an unusual looking mole

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91
Q

ecchymosis

A

a non-blanching skin discoloration due to the escape of blood from ruptured blood vessels

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92
Q

eczema

A

a chronic inflammatory skin condition that results in itching, scaling, and thickening of the skin

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93
Q

eccrine glands

A

sweat glands

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94
Q

electrolysis

A

a process for hair removal; an electric current is applied to the unwanted hair follicle

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95
Q

ephelis

A

also called a freckle

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96
Q

epidermis

A

the most outer layer of the skin that is exposed to the environment

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97
Q

erosion

A

loss of the epidermis due to friction or pressure

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98
Q

erysipelas

A

an acute streptococcus bacterial infection that results in inflammation

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99
Q

erythema

A

a form of skin inflammation; conditions develop in the fatty parts of the skin

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100
Q

erythema multiforme

A

abnormal redness of the skin usually caused by inflammation

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101
Q

erythema nodosum

A

a skin infection where red bumps appear on the shins

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102
Q

erythrasma

A

a skin infection where irregular pink patches are localized or generalized, and turn to brown scales

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103
Q

erythroderma

A

an extensive reddening of the skin often due to exfoliation

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104
Q

eschar

A

a dead tissue piece that is shed from the skin after a burn or another infection

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105
Q

ezanthem

A

an extensive rash

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106
Q

exanthema

A

an eruption that develops on the skin

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107
Q

excoriation

A

when the skin is covered by scabs due to scratching

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108
Q

exfolfiation

A

a process where a layer of the skin is removed

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109
Q

exfoliative dermatitis

A

significant scaling along the skin

110
Q

eye lid rejuvenation

A

a cosmetic procedure to improve the appearance of the upper eyelids, lower eyelids, or both

111
Q

face lift

A

a surgical procedure that improves visible signs of aging in the face and neck

112
Q

fissure

A

a deep furrow, cleft, or slit in the epidermis

113
Q

flush

A

a blushing effect

114
Q

folliculitis

A

inflammation of hair follicles from infection

115
Q

freckle

A

a cluster f brownish spots on the skin caused by deposition of pigment

116
Q

furuncles

A

a boil that can develop in a hair follicle

117
Q

granuloma

A

a tissue that is produced due to an infection or inflammation

118
Q

granuloma annulare

A

a chronic skin disease where raised, red bumps appear in a circle or ring with a normal or sunken center

119
Q

hair follicle

A

a follicle that will support the production of hair

120
Q

halitosis

A

breath odor that develops due to improper oral hygiene

121
Q

hematoma

A

a collection of blood outside of blood vessels that develops due to an injury to the wall of a blood vessel

122
Q

herpes simplex

A

a recurrent, self limited viral disease that causes the eruption of fluid-containing vesicles

123
Q

herpes zoster

A

also known as shingles, is a painful, viral infection of the nerves that causes a painful rash with small blisters

124
Q

hidrocystoma

A

a sweat gland cyst

125
Q

hidrosis

A

the body’s natural production of sweat

126
Q

hidrotic

A

relating to sweating

127
Q

hirsutism

A

excessive facial and body hair growth especially found in women that can be treated by a derm

128
Q

hives

A

an allergic reaction from food or medication were red, itchy, and swollen spots appear on the skin

129
Q

hyalin

A

a clear material produced in the body as a result of connective tissues dying

130
Q

hyperhydrosis

A

excess sweating

131
Q

hyperpigmentation

A

excess, darker than normal, pigmentation

132
Q

hypertrichosis

A

hair growth that develops in various locations

133
Q

hypohydrosis

A

a disorder where a person does not experience much sweating

134
Q

hypotrichosis

A

a condition where a person does not have enough hair on their body

135
Q

hypopigmentation

A

diminished, paler than normal, pigmentation

136
Q

ichthyosis

A

a hereditary skin disease where epidermis flakes off in larger scales or plates

137
Q

immunocompromised

A

a condition where the immune system has been impaired by a disease and decreases a person’s ability to fight infections

138
Q

impetigo

A

a bacterial infection where microscopic pus-filled blisters appear

139
Q

intertrigo

A

inflammation produced in the warm and moist parts of the body including areas around the groin and between skin folds or under the breasts

140
Q

induration

A

the hardening of normally soft skin due to inflammation, cellular infiltration, or an accumulation of blood

141
Q

inflammation

A

the reaction of the skin that causes redness, swelling, heat, and pain due to injury, infection, or allergic reaction

142
Q

intraductal papilloma

A

benign tumors in the breast ducts

143
Q

iodine

A

a nonmetallic element; used as a topical solution to prevent infections

144
Q

juvederm

A

a cosmetic, dermal filler gel injection consisting of hyaluronic acid

145
Q

keloids

A

a firm pink, raised scar tissue caused by excessive tissue repair

146
Q

keratinocytes

A

also called squamous cells; the main cell found in the epidermis

147
Q

karatosis

A

a growth of skin that may feel horny and hollow; a wart or a callus may be interpreted as a keratosis

148
Q

keratoacanthomas

A

a skin growth that is round and fleshed-colored that contain pasty material

149
Q

keratosis pilaris

A

a genetic skin condition where rough bumps appear on the back, upper arms and thighs

150
Q

koilonychia

A

a disease that develops in fingernails; the nails will become thin and develop concave shapes

151
Q

labial

A

relating to the lip

152
Q

laser resurfacing

A

a cosmetic procedure where high-energy light is used to burn away damaged skin, including wrinkles and fine scars

153
Q

lentigo

A

a freckle or other pigmented spot found on the surface of the skin

154
Q

lice

A

contagious, tiny insects infested in the scalp, and sometimes on the eyebrows and eyelashes causing intense itching

155
Q

lichen

A

refers to clinical lesions that various skin diseases cause by the eruption of flat papules

156
Q

lichenification

A

diffuse, thickening of the skin due to scratching and rubbing

157
Q

liniments

A

liquids that produce heat; the liquid is applied to the skin and may help relieve pains or irritation

158
Q

lipedema

A

a condition where fatty tissues develop on the legs

159
Q

lipoma

A

a benign tumor under the skin composed of fatty tissue

160
Q

liver spots

A

discoloration of the skin due to aging and sun exposure

161
Q

lupus

A

an inflammatory condition that does not have any cures; causes fatigue, joint pain, and a butterfly rash

162
Q

macule

A

a change in color of something

163
Q

macular stains

A

also called angel’s kisses or stork bites, are faint, red marks on the skin presented at birth

164
Q

malignant melanoma

A

a rare but sometimes fatal type of skin cancer that starts off as a mole and turns cancerous

165
Q

melanin

A

a natural pigment in the body that turns skin to a dark tone

166
Q

melanocytes

A

an epidermis cell that produce melanin

167
Q

melanosis

A

a condition where melanin production becomes too excessive; the added production causes the skin to become dark in various areas

168
Q

melasma

A

a light to dark brown, patchy pigmentation of the cheeks and occasionally the forehead and upper lip that results from sun-exposure and is associated with estrogen

169
Q

micrococcus

A

a bacteria with cells up to 3 micrometers in diameter

170
Q

mite

A

a small spider-like insect that may be a parasite on human skin

171
Q

moles

A

a small, dark raised congenital spot on the skin

172
Q

mongolian spots

A

bluish-black congenital skin marks found at birth, on the lower back and buttock and usually goes away after three to five years after birth

173
Q

necrobiotic disorder

A

a disorder that involves collagen in the dermis being destroyed

174
Q

necrotizing fasciitis

A

a bacterial infection known as flesh-eating disease

175
Q

neurodermatitis

A

a condition loosely related to eczema

176
Q

nevi flammeus

A

a birthmark consisting of malformed, dilated blood vessels in the skin that leave pink, red, or purple marks on the outer layer of the skin

177
Q

neck lift

A

a set of cosmetic procedures to enhance the appearance of the neck, to help present a more youthful look

178
Q

nevus

A

a skin issue that is noticeable at birth; this may be a birthmark or a mole

179
Q

nodule

A

also called papule, is a raised area of the skin that does not contain any fluids

180
Q

ochronosis

A

discoloration of body tissues

181
Q

onychomycosis

A

chronic fungal infection of the nails causing chronically thickened, splitting, rough, and discolored nails

182
Q

onychocryptosis

A

an ingrown toenail

183
Q

open comedo

A

also called a blackhead

184
Q

pallor

A

a pale appearance; a white look to the skin

185
Q

panniculitis

A

inflammation in the adipose tissue, particularly of the skin; this condition may be characterized by red nodules that develop all around

186
Q

papilloma

A

a benign tumor in the skin or in a mucous membrane

187
Q

papule

A

a raised lesion on the body; the lesion is an effect of the skin condition and will have a significant border defining its shape

188
Q

paronychia

A

an infection in the skin near a nail; a pus-forming, fungal skin infection that causes inflammation around a fingernail or toenail

189
Q

patch

A

a circumscribed flat, discolored spot on the skin

190
Q

pediculosis

A

an infestation of lice

191
Q

pemphigus

A

an autoimmune disease where the immune system will attack healthy cells around the skin triggering blisters and sores

192
Q

perlane

A

a cosmetic dermal filler injection used to soften your wrinkles and facial lines and lift to add volume to the face

193
Q

perleche

A

a crack that appears at the corners of the mouth

194
Q

petechiae

A

a series of patches that develop on a mucous membrane

195
Q

piloerection

A

when the hairs on the skin become erect; goosebumps

196
Q

pilonidal sinus

A

a cyst or sinus with hair

197
Q

pimple

A

an inflamed lesion on the skin that resembles a pink bump

198
Q

pinta

A

a bacterial skin disease that is more likely to be found in tropical parts of the americas

199
Q

pityriasis

A

a skin disease that is the production of fine scales along the body

200
Q

pityriasis rosea

A

a common skin condition resembling patches of scaly, pink, and inflamed skin usually found on the torso

201
Q

plaque

A

a small, elevated, solid lesion with a disk-shaped formation

202
Q

pore

A

a tiny opening on the surface of the skin

203
Q

porokeratosis

A

a keratinization disorder

204
Q

poroma

A

a neoplasm of cells that forms in the opening of sweat glands

205
Q

port-wine stains

A

a birthmark consisting of malformed, dilated blood vessels in the skin leaving pink, red, or purple marks on the skin

206
Q

pressure ulcer

A

an ulcer that develops in the skin over a bony tissue

207
Q

prickly heat

A

a skin condition that resembles a rash, and is caused by sweat that is trapped under the skin

208
Q

prurigo

A

inflammation in the skin; occurs due to papules consistently erupting

209
Q

pruritis

A

a skin condition that causes itching

210
Q

psoriasis

A

a chronic skin condition that causes rapid skin growth which results in redness, irritation, and scaly patches

211
Q

punch grafts

A

a dermatological procedure to help treat deep acne scars by removing the scar on the skin and placing a skin graft in the area of the cut

212
Q

purpura

A

a series of red or purple spots that develop on the skin; the spots are triggered by bleeding conditions under the skin and may be due to vascular or coagulation issues

213
Q

pus

A

a yellow or white fluid formed in infected tissue

214
Q

pustule

A

also called a pimple; is an inflamed lesion on the skin that resembles a pink bump

215
Q

pyoderma

A

a skin disease that has pus; may involve an ulcer or other conditions where the skin develops pus

216
Q

pyogenic granuloma

A

raised marks caused by excessive growth of the capillaries

217
Q

radiesse

A

a new long-lasting cosmetic filler injection made of microscopic balls of calcium hydroxylapatite that injects into areas such as the lips for more fullness

218
Q

rash

A

a series of spots that develop on the skin

219
Q

restylane

A

a cosmetic gel injection used to restore the skin’s volume to enhance their natural look with a soft and revitalizing appearance

220
Q

rhytidectomy

A

a face-lift procedure

221
Q

ringworm

A

a fungal skin infection with the formation of red, blistery, ring-shaped patches

222
Q

rosacea

A

the facial skin becoming red and may include a blushing or flushing appearance

223
Q

salicylic acid

A

a keratolytic drug used by dermatologists, in dermatological procedures to remove the out layer of the skin

224
Q

sarcoidosis

A

a disease that causes inflammation in the lymph nodes and other organs

225
Q

scab

A

dried blood pus, or other fluids on the surface of the skin

226
Q

scabies

A

a contagious skin infection caused by mites that result in intense itching

227
Q

scales

A

sry skin that flakes due to dead skin cells

228
Q

scar

A

a fibrous tissue on the skin due to an injury, skin disease, rash, or acne

229
Q

scleroderma

A

crest syndrome; the skin becomes tight due to swelling

230
Q

sebaceous glands

A

microscopic glands in the skin that secrete oil to the surface of the skin

231
Q

seborrhea

A

also known as dandruff when this occurs on the scalp

232
Q

seborrheic keratosis

A

a non-cancerous wart-like spots on the skin that is commonly flesh-colored, brown, or black

233
Q

sebum

A

the oily compound produced by the sebaceous glands

234
Q

shingles

A

a viral infection of the nerve that causes a painful rash with small blisters

235
Q

skin cancer

A

the uncontrolled growth of cancerous tumor on the skin that can spread to other tissues and organs

236
Q

skin cancer screening

A

skin cancer screening involves a 2 to 3 minute visual inspection of the patient’s body for irregular spots or moles

237
Q

skin resurfacing

A

a cosmetic treatment performed to improve the texture, clarity and overall appearance of skin

238
Q

skin surgery

A

either a surgical or cosmetic procedure rapidly advancing in the areas of medicine, surgery, and cosmetics

239
Q

skin tags

A

a small non-cancerous, flesh-colored skin flaps that appears on the neck, armpits, or groin

240
Q

spider angioma

A

an abnormal collection of blood vessels near the skin’s surface causing bright red mark with a distinct dark spot

241
Q

spider veins

A

a dilated blood vessels that cause dark red blotches on the surface of the skin

242
Q

squamous cells

A

also know as keratinocytes; the main cell found in the epidermis

243
Q

squamous cell carcinoma

A

result from skin cancer and becomes an open sore

244
Q

steatoma

A

a cyst or tumor found in the sebaceous gland

245
Q

stretch marks

A

scaring caused by the stretching or tearing of the skin

246
Q

striae

A

scaring caused by the stretching or tearing of the skin

247
Q

subcutaneous

A

under the skin

248
Q

subcutaneous layer

A

the deepest layer of the skin that lies below the dermis

249
Q

subcutis

A

also called the subcutaneous layer

250
Q

sunburn

A

an injury on the skin due to excess exposure to sunlight or sunlamps

251
Q

sycosis

A

inflammation in the hair follicles around the face

252
Q

telangiectasia

A

also called spider veins; dilated blood vessels that cause dark red blotches on the skin

253
Q

tinea

A

a fungal skin infection that can be jock itch or athletes foot

254
Q

tinea versicolor

A

a chronic non-inflammatory fungal infection where white or light brown patches appear on the skin that can be treated

255
Q

toxic epidermal necrolysis

A

a severe skin disorder caused by a reaction to medicine where the top layer of skin starts blistering and peeling

256
Q

tretinoin

A

a common, dermatological drug, chemically related to vitamin A used to treat acne

257
Q

ultraviolet

A

UV light

258
Q

unguis

A

a nail

259
Q

urticaria

A

also known as hives; an allergic reaction from food or medication where red, itchy, and swollen spots appear on the surface of the skin

260
Q

urushiol

A

a toxic substance found in resin that causes allergic skin reaction

261
Q

verrucae

A

a plantar wart that develops on the soles of the feet or near the toe

262
Q

vitiligo

A

a skin disorder where smooth, white patches appear in the skin due to the loss of pigment-producing cells

263
Q

volume restoration

A

a treatment that provides long-lasting results to give you a natural, youthful appearance

264
Q

wart

A

a small non-cancerous skin growth caused by a virus that appears on the surface of the skin

265
Q

weal

A

a bump produce on the skin due to a blow

266
Q

wheal

A

swelling on the skin due to an insect bite

267
Q

whitehead

A

a type of acne with a white or yellowish head on the skin

268
Q

wrinkle

A

a small crease or fold in the skin surface resulting from aging or frowning

269
Q

xeroderma

A

a disease triggered by the skin being too dry

270
Q

xerosis

A

excessive and pathological dryness of the skin or mucous membranes