Dermatology Conditions - Path

Question 1

Acne - Pathophysiology (10)

Answer 1

1) hypercornification 2) narrowing of hair follicle 3) increased androgen sensitivity of hair follicle 4) increased sebum production 5) sebum traps in hair follicle 6) Propionibactrium acne colonies anaerobic hair follicle 7) P. acne breaks down sebum lipids into free fatty acids 8) free fatty acids cause inflammation 9) neutrophil attraction 10) pus formation

Question 2

Psoriasis - Pathophysiology (3)

Answer 2

1) T cell activation upregulates proinflammatory Th1 cytokines (e.g. growth factors) 2) increased epidermal cell turnover 3) uncontrolled hyperproliferation of keratinocytes