Dermatology conditions Flashcards

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1
Q

Eczema

A

Chronic, itchy, inflammatory skin condition that affects people of all ages, although presents more frequently in childhood

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2
Q

Eczema clinical features

A

Presence of an itch

Generalised dryness

Affects flexures of the limbs (back of knees, inner elbows)

Thickened (lichenified) skin from repeated scratching

Family/personal history of atopy

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3
Q

Eczema severity

A

Mild - areas of dry skin & infrequent itching

Moderate - areas of dry skin, frequent itchy & redness

Severe - widespread areas of dry skin, incessant itching & redness

Infected - eczema is weeping, crusted or there are pustules with fever or malaise

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4
Q

Eczema mx

A

Importance of skin care measures & avoidance of triggers
Mild eczema
- Emollients
- Mild potency topical corticosteroids
Moderate eczema
- Emollients
- Moderate potency topical corticosteroids
- Topical calcineurin inhibitors (tacrolimus or pimecrolimus)
- Bandages
Severe eczema
- Emollients
- Potent topical corticosteroids
- Topical calcineurin inhibitors (tacrolimus or pimecrolimus)
- Bandages
- Phototherapy
- Oral corticosteroids

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5
Q

Eczema referral

A

Uncertain diagnosis

Not controlled with current treatment

Recurrent secondary infection

High risk of complications

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6
Q

Eczema complications

A

Infection - eczema herpeticum, superficial fungal infections

Psychosocial problems

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7
Q

Acne vulgaris

A

Chronic inflammatory skin condition affecting mainly the face, back and chest

Characterised by blockage and inflammation of the pilosebaceous unit (hair follicle, hair shaft & sebaceous gland)

Non-inflamed lesions = comedones, inflammatory acne lesions = papules & pustules

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8
Q

Acne fulminans

A

Sudden severe inflammatory reaction that precipitates deep ulcerations & erosions, sometimes with systemic effects (fever, arthralgia & myalgia)

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9
Q

Acne vulgaris clinical features

A

Comedones - blackheads or whiteheads

Inflammatory lesions - papules, pustules, nodules or cysts

Scarring

Pigmentation

Seborrhoea (increased sebum production)

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10
Q

Acne vulgaris mx advice

A

Avoid over-cleaning the skin

Use a non-alkaline synthetic detergent cleansing product BD on acne-prone skin

Avoid oil-based products & remove make-up at the end of the day

Persistent picking or scratching of lesions can increase the risk of scarring

Treatments may irritate the skin, especially at the start of treatment

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11
Q

Mild to moderate acne mx

A

12 week course of one of the following first-line options:

  • fixed combination of topical adapalene with topical benzoyl peroxide
  • fixed combination of topical tretinoin with topical clindamycin
  • fixed combination of topical benzoyl peroxide with topical clindamycin
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12
Q

Moderate to severe acne mx

A

12 week course of one of the following first-line options:

  • fixed combination of topical adapalene with topical benzoyl peroxide to be applied once daily
  • fixed combination of topical tretinoin with topical clindamycin to be applied once daily
  • fixed combination of topical benzoyl peroxide with topical adapalene to be applied once daily, with oral lymecycline/doxycycline
  • topical azelaic acid applied twice daily, with either oral lymecycline/doxycycline

COCPs in combination with topical agents can be considered as an alternative to systemic antibiotics (eg. Dianette)

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13
Q

Acne vulgaris referral

A

Urgently refer people with acne fulminans on the same day to the on-call hospital dermatology team

Mild to moderate acne that have no responded to two completed courses of treatment

Moderate to severe acne that has not responded to previous treatment that includes an oral antibiotic

Acne with scarring

Acne with persistent pigmentary changes

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14
Q

Acne vulgaris complications

A

Skin changes - scarring, hyperpigmentation, depigmentation

Psychosocial effects

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15
Q

Psoriasis

A

Systemic, immune-mediated, inflammatory skin disease with typically has a chronic relapsing-remitting course & may have nail and joint involvement

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16
Q

Psoriasis types

A

Chronic plaque psoriasis - most common form

Localised pustular psoriasis

Flexural psoriasis

Guttate psoriasis

Erythrodermic psoriasis - potentially life threatening medical emergency

Generalised pustular psoriasis

Nail psoriasis

17
Q

Psoriasis clinical features

A

Extensor surfaces (elbows & knees), trunk, flexures, sacral & natal cleft, scalp & behind the ears & umbilicus

Size & shape of lesions - large plaques, usually a clear delineation between normal & affected skin

Silvery scale

Auspitz sign - pinpoint bleeding when adherent psoriatic scales are scraped away

Involvement of other areas - joint tenderness, nail changes

18
Q

Psoriasis mx

A

Lifestyle advice - weight loss, smoking cessation & alcohol reduction

Management of associated stress, distress, anxiety and/or depression

Topical preparations - emollients, corticosteroids, vitamin D analogues, coal tar & short-contract dithranol

Specialist treatments - topical calcineurin inhibitors, phototherapy, systemic/biologic therapy

19
Q

Psoriasis referral

A

Uncertain diagnosis

Psoriasis is extensive - > 10% of body surface affected

Resistant to topical drug treatments in primary care/treatments are not tolerated

Severe nail disease

20
Q

Actinic keratosis

A

Precancerous scaly spot found on sun-damaged skin

May be considered an early form of cutaneous SCC

21
Q

Actinic keratosis risk factors

A

Fair skin with a history of sunburn

History of long hours spent outdoors for work or recreation

Defective immune system

22
Q

Actinic keratosis pathophysiology

A

Result of abnormal skin cell development due to DNA damage by short wavelength UVB

More likely to appear if the immune function is poor, due to ageing, recent sun exposure, predisposing disease or certain drugs

23
Q

Actinic keratosis clinical features

A

Flat or thickened papule or plaque

White or yellow, scaly, warty or horny surface

Skin coloured, red or pigmented

Tender or asymptomatic

Site - sun-exposed areas

24
Q

Actinic keratosis diagnosis

A

Clinical

Dermoscopy

Occasionally, biopsy → exclude SCC or if treatment fails

25
Q

Actinic keratosis mx

A

Prevention of further risk - sun avoidance, sun cream

Fluorouracil cream - 2-3 week course

Topical diclofenac for mild cases

Removal by cryotherapy, curettage & cautery or excision

26
Q

Actinic keratosis complications

A

Increased risk of developing cutaneous SCC

  • patient > 10 actinic keratoses is thought to be about 10 to 15%
27
Q

Bowen’s disease (intraepidermal SCC)

A

Malignant SCC cells are confined to the epidermis

28
Q

Bowen’s disease risk factors

A

Sun exposure

Arsenic ingestion

Ionising radiation

HPV infection

Immune suppression due to disease (CLL) or medicines (eg. azathioprine, ciclosporin)

29
Q

Bowen’s disease aetiology

A

Ultraviolet radiation - damages the skin cell nucleic acids, resulting in a mutant clone of the gene, p53 → uncontrolled growth of the skin cells

HPV

30
Q

Bowen’s disease clinical features

A

Irregular scaly plaques

Often orange-red colour but may also be brown

Most often on sun-exposed sites of the ears, face, hands & lower legs

31
Q

Bowen’s disease diagnosis

A

Recognised clinically

Dermatoscopy

Diagnosis may be confirmed by biopsy → histology reveals full thickness dysplasia of the epidermis

32
Q

Bowen’s disease mx

A

Observation - may not to be necessary to remove all lesions, particularly in elderly patients

Topical fluorouracil

Cryotherapy

Excision

Photodynamic therapy

33
Q

Bowen’s disease complications

A

Invasive SCC

Other skin cancers - BCC and melanoma