Dermatology: Antibiotic Agents

Question 1

What are the antibiotics we have to know for our test?

Answer 1

• Bacitracin
• Mupirocin
• Polymyxin B, neomycin, gentamicin
• Topical & oral Abx in acne

Question 2

Bacitracin is active against what type of organisms?

Answer 2

Gram-positive organisms

Ex: strept, pneumo, staph

Question 3

What vehicle is Bacitracin compounded into & with what other medications?

Answer 3

Compounded into an ointment base alone or in combination with neomycin, polymyxin B, or both.

“Baci Neo poly B”

“Basic bitches like new polyester boots”

Question 4

Bacitracin is well absorbed through the skin.

T/F?

Answer 4

False, it is poorly absorbed through the skin.

Question 5

Is systemic toxicity rare with Bacitracin ointment?

What is frequently seen?

Answer 5

Yes, it is.

Frequently seen: allergic contact dermatitis in ointments with neomycin.

Question 6

Mupirocin is active against what type of organisms?

Answer 6

Gram +

MRSA

Question 7

What vehicles does Mupirocin come in?

Answer 7

Cream or ointment

Question 8

What are the adverse effects of Mupirocin?

Answer 8

stinging

burning

pruiritis

headache

Question 9

What organisms is Polymyxin B effective against?

Answer 9

gram negative organisms: P aeruginosa, Enterobacter, E.coli

All gram + organisms are resistant.

Question 10

What organisms is Neomycin active against?

Answer 10

aerobic Gram + and Gram - bacilli: Staph aureus & Ecoli

Question 11

Is there sensitization associated with Neomycin?

Answer 11

Yes, contact dermatoses as high as 30%

Question 12

T/F: Gentamicin has greater activity against P aeruginosa than neomycin.

Answer 12

TRUE