Dermatology Flashcards
33F. Itchy rash on both elbows. Worsening for the past week. O/E: multiple polygonal, flat-topped papular lesions, 5mm diameter on the flexural surface of her elbows, bilaterally. No other rash on the rest of her body. What is the most likely diagnosis?
Lichen planus
Causes of pruritus ani
Fissure Incontinence Poor hygiene Tight underwear Threadworm Fistula Dermatoses Lichen sclerosis Anxiety Contact dermatitis Unknown cause
Management of pruritus ani
Hygiene Avoid scratching Avoid foods that loosen stool Soothing ointment Mild topical corticosteroids if inflammation Oral antihistamine for night time
Pre-malignant, crumbly, yellow-white scaly crusts on sun-exposed skin from dysplastic intra-epidermal proliferation of atypical keratinocytes. What is the diagnosis? Give 2 differentials
Actinic (solar) keratoses
Bowen’s
Psoriasis
BCC
Seborrheic keratosis
Investigation and Management of actinic keratoses
Biopsy if in doubt of Dx
Prevention of risk (sun avoidance) Fluorouracil cream (+ hydrocortisone) Topical diclofenac Topical imiquimod Cryotherapy Curettage and cautery
Well-defined, slowly enlarging red scaly plaque with a flat edge (asymptomatic). Histology shows full thickness dysplasia/carcinoma in situ. Diagnosis?
Bowen’s disease
i.e. SCC in situ
Management of Bowen’s disease
Fluorouracil Imiquimod (inflammation) Cryotherapy Photodynamic therapy Curettage, excision
Causes of Bowen’s disease
UV exposure Radiation Immune suppression Arsenic HPV (in genital area)
Most common skin cancer?
Basal Cell Carcinoma
Describe the 2 types of BCC
Nodular: pearly nodule, rolled telangiectasia edge, face
Superficial: red scaly plaque, trunk/shoulders
Management of BCC
Excision Cryotherapy Curettage Radiotherapy Photodynamic therapy Imiquimod/fluorouracil (superficial low risk)
Management of primary squamous cell carcinoma?
Local complete excision
Most common cancers causing cutaneous mets?
Breast Stomach and colon Lung GU (uterus, ovary, kidney, bladder) Non-Hodgkins, Leukaemia
Describe Paget’s disease of the nipple
Itchy red scaly crusted nipple, from direct extension of intraductal adenocarcinoma
How do you differentiate Paget’s disease of the nipple from eczema?
Eczema is bilateral, non-deforming, comes and goes
Risk factors for melanoma?
UV exposure Sun burn Fair complexion >50 melanocytic/dysplastic naevi FHx Prev melanoma ^Age
Ring-like (annular) lesions indicate what type of infection?
Fungal infection
Target-like pattern of lesions =?
Erythema multiforme
> 5 cafe au last spots, consider what condition?
Neurofibromatosis
What is melasma?
Brown/greyish patches of pigmentation develop, usually on face
What can cause melasma?
Pregnancy
COCP
What systemic disease that can cause hyperpigmentation?
Addison’s
Haemachromatosis
Investigations in itch?
FBC Haematinics LFT U+E ESR Glucose TSH
Skin signs in DM
Flexural candidiasis Necrobiosis lipoidica Acanthosis nigricans Granuloma annulare Folliculitis
Rare granulomatous skin disorder that can affect the shin of insulin-dependent diabetics?
Necrobiosis lipoidica
Skin disorder characterised by hyperpigmentation and hyperkeratosis of the skin, occurring mainly in the folds of the skin in the armpit, groin and back of neck?
Acanthosis nigricans
Rare skin disorder with groups of small firm bumps in the skin forming a characteristic ring shaped (annular) patch. Typically 1-2 sites of the body, often bony areas (back of hands, feet, elbows or ankles)
Granuloma annulare
Skin signs in coeliac disease?
Dermatitis Herpetiformis
Dermatitis Herpetiformis
a) Pathophysiology?
b) Immediate management?
c) Diagnosis?
a) IgA deposits in dermis
b) Dapsone (antibiotic - previously used to treat leprosy), usually reduces itch in 3 days; Gluten free diet
c) Skin biopsy (direct immunofluorescence shows deposition of IgA in upper dermis)
Which disease is dermatitis herpetiformis associated with?
Coeliac disease
Features of dermatitis herpetiformis?
ITCHY
Vesicular skin lesions on extensor surfaces (elbows, knees, buttocks)
Skin signs in IBD?
Erythema nodosum
Pyoderma gangrenosum
Rapidly enlarging, very painful ulcer on lower limbs w/ fever, myalgia. Seen in patients with IBD?
Management?
Pyoderma gangrenosum
Oral steroids
Skin signs in Lupus?
Facial butterfly rash
Photosensitivity
Diffuse alopecia
Lupus erythematosus (chilblain, discoid, psoriasis-like plaques, vasculitis, oral ulcers, palmar erythema, periungal erythema, raynauds)
Erythema multiforme is a hypersensitivity reaction usually triggered by what organism?
Herpes simplex
Management of erythema multiforme?
Topical steroid for discomfort
Aciclovir for HSV
Resolves spontaneously
Causes of acanthosis nigricans?
Obesity
DM
Lymphoma
Gastric Ca
RFs for psoriasis and triggers?
FHx
Triggers: stress, infections, skin trauma, drugs (lithium, NSAIDs, BB), alcohol, obesity, smoking, climate
Systemic upset found with generalised severe psoriasis?
^WCC
Fever
Dehydration
Nail changes in psoriasis?
Pitting
Onycholysis
Thickening
Subungual hyperkeratosis
Scaling under the nail due to excessive proliferation of keratinocytes in the nail bed and hyponychium
Subungual hyperkeratosis
Differentials for psoriasis?
Eczema
Tinea (few lesions)
Mycosis fungoides (asymmetric)
Seborrheoic dermatitis
Management of psoriasis
Topical emollient + steroids (Betnovate) Topical vit D prep (Calcipotriol) DOVOBET (vit D + steroid) COAL tar Dithranol Retinoid (Acitretin) Phototherapy Methotrexate, Ciclosporin Infliximab
Scalp psoriasis management?
Steroid
Vit D
Coal tar shampoo
Why is it important to tell parents of eczema patient to report any severe weeping rash, e.g. around the mouth?
May be eczema herpeticum - primary herpes infection, which may be fatal
Management of eczema?
Emollient, soap substitutes
Topical steroids
Pimecrolimus (topical calcineurin inhibitor)
Abx for infection
Tacrolimus/methotrexate/azathioprine/ciclosporine in severe
Antihistamines for itch (hydroxyzine)
What is a topical steroid-free anti-inflammatory medication used to treat atopic dermatitis?
Pimecrolimus
What does seborrheic dermatitis look like?
Red, scaly
What areas does seborrheic dermatitis affect?
Scalp (dandruff), eyebrows, nasolabial folds, cheeks, flexures
What causes seborrheic dermatitis?
Over-growth of yeast (malassezia)
How is seborrheic dermatitis treated?
Daktacort (steroid + anti fungal)
Management of acute flare of contact dermatitis?
Topical steroid
Side effects of topical steroid use?
Skin thinning Striae Telangiectasia Worsening of infection Contact dermatitis
What investigation can help you diagnose tinea/ringworm?
Skin scraping/ Scalp brushings/ Nail clippings for microscopy and culture