Dermatology Flashcards
Prevalence of eczema under 5s
5%
Patch testing
Put patch on for 48 hours then remove.Mark sites.Check again at 96h.
Topical immunomodulators eczema
Tacrolimus, sirolimus
Eczema resolved by 5 years
40%
First line eczema- topicals
EmollientsCorticosteroidsCalcineurin
Systemic eczema treatment
Antihistamines.Prednisolone.Antibiotics (if infected)PUVA
Super systemic eczema treatment
MethotrexateCiclosporinAzathioprine
Lichen simplex
Type of eczema
Pompholyx
Eczema rapid in fingers.
Guttate
usually after infection- beta haem
Erythrodermic psoriasis
irritated by tar/dithranol/UV light.
Pustular psoriasis
Acetretin (remember pregnancy things).
Auspitz sign
Psoriasis- flake falls off and reveals blood vessels underneath.
Nails in psoriasis
Pitting and ridges.OnycholysisDystrophyHyperkeratosis.
Home (4 weeks) treatment psoriasis
TarCorticosteroid creamsVit D analogue
Hospital treatments for psoriasis
DithranolPUVA
Serious psoriasis treatment
Systemic biologics.
Lichen planus
Stress related.Self-limiting- flexors.Increased keratin and hypertrophy.Cellular inflitrate- resolves in 8-12m.
Wickham’s striae
white lines in lichen planus
Pterygium
scarring of nail bed in lichen planus.
Drugs causing urticaria
ACE inhibitors, anaesthetics, antibiotics.
Chronic urticaria
More than 6 weeks.
Investigations for urticaria
ANA titres.Hep B/CTFT
Urticaria hypersensitivity type
IgE Type 1 hypersensitivityInvolves complement cascade.
Pemphigus cause
Antibodies against keratinocytes- intra epidermal desmosomes.
Where is pemphigus?
TrunkScalpMucus membranes.
Biopsy findings pemphigus
direct immunofluorescence IgG and C3
Treatment pemphigus
Prednisolone + Azathioprine.
Nikolsky sign
Pemphigus bulla breaks easily
Pemphigoid cause
Autoimmune against basement membrane.
Rosacea
no comedones.telangiectasia papulespustulesrhinophyma
Acne vulgasis cause
follicular pluggingenlarged glands and XS sebum.
1st choice acne treatment
Benzoylperoxidase 2.5-5%
Pityriasis rosea
Prodromal sickness.ACUTEself-limiting20-30years.Herald patch –> Christmas tree.RED AND SCALY
Describe tinea
itchy, central clear bit with red, scaly edge.
Topical antifungal
imidazole
Systemic antifungal
terbinafine
Pityriasis versicolor cause
orbiculare FUNGUSMalasezzia furfur
Where is versicolor?
chest, back, trunk, arms
Versicolor Ix
Wood’s light- yellow/green fluorescence.
Treatment cellulitis
PenicillinFlucloxacillin.
Scabies name
Sarcopted scabiei
Incubation period for scabies
4-6 weeks.
What does scabies look like?
Papules and nodules.Hands and feed, axillae, breast, buttock
Treatment scabies
Permethrin + Malathion topical
Causes of dermatitis herpetiformis
HLA B3, DR3, coeliac.
Subepidermal blistersMicroabscesses in paillae
Dematitis herpetiformis
Dapsone
Leprosy drug- dermatitis herpetiformis
Causes of erythema nodosum(inflammed subcutaneous fat)
IBD.Lupus/sarcoidosis.Infection- strep and TB.Drugs- sulfonamides, OCP
Prognosis for erythema nodosum
Resolve in 6 weeks.
Biggest cause of erythema multiforme
HSV
Causese of multiforme
Infection- HSV, mycobacterium, hep B, EBV.Lupus/SarcoidosisLeukemia.Pregnancy and pre-menstrual.Drugs- sulphonamides, antibiotics.
Target lesions
Multiforme.Raised.
Steven Johnsons
Mucosal multiforme.
Pyoderma gangrenosum causes
IBDRheumatoidMyeloma
Pyoderma gangrenosum looks like
ulcerated nodues, RAPIDY growing.
Heals with scarring.
gangrenosum.
Lupus pernio
cutaneous sarcoid.
Where is lupus pernio?
Alar rim of nose, mid face.
What does lupus pernio look like?
Violet papules and plaques.
Lupus vulgaris
cutaneous TB
Lupus vulgaris looks like
brown, hears slowly, scars,Dark rim, pale in the middle. ULCERS
Acanthosis nigricans may be a sign of
malignancyacromegalydermatomyositissclerodermaWilson’s
thrombophlebitis is a sign of:
intra-abdominal malignancy.
Necrobiosis lipoidica looks like
shiny patches that grow other m to yr.Red brown turn into yellow patches.Pre-tibia.
Granuloma annulare looks like
Erythema, firm ring shaped with a raised edge.
Hyperlipidaemias involved in Xanthelasma
types 2 and 4
Short contact dithranol
5-60 mins a day.
concentrations of dithranol
0.1%1%2%
Calcipotroil
Vit D derivativesGuttate and alopecia areata
How do you take calcipotriol?
Cream twice daily.
SE calcipotriol
itchy, redness in 20% etc.DON’t use in Flexures.
Calcipotriol works by:
decreasing rate of cell division.
Acitretin
Vit A retinoid.
Acitretin dose.
0.25mg/kg/day ORAL
SE Acitretin
Dry mouthCrusty noseItchingDeranged LFTS.MUST USE CONTRACEPTION FOR 2 YEARS
CI for coal tar
Prenancy.
Emmolient examples.
E45DiprobaseOily creamEpaderm
Steroid examples
1-2.5% hydrocortisoneEumovateBetnovateDermovate.
Salicylic acid
Lifts scales up
CI for salicylic acid
ASPIRIN allergy
PUVA dose
0.6-0.8mg/kg 1-2 hours before.
Methotrexate dose
0.57-1.5mg WEEKLY
Monitoring methotrexate
LFTs
Monitoring cyclosporin
Renal function
Monitoring azathioprine
LFTs
Terbinafine
Oral or topical antifungal
Basal cell papilloma
seborrhoeic keratosis
what does a seb. keratosis look like?
brown/yellow round oval WELL demarcated.
Treatment seb.keratosis
CryotherapyEfudix (5-fluorouracil)Curettage
Keratocanthoma
low-grade malignancy.
What does a keratocanthoma look like?
RAPIDnodule with central ulcer (crater).