Dermatology Flashcards
what is the life cycle of a nevus?
junctional nevus (flat, brown)–> compound (raised, darker)–> dermal nevus (fibrotic, de-pigmented)
What is the most sensitizing topical antibiotic?
neomycin
What types of nevi are there? What conditions are they a/w?
atypical- melanoma, blue, halo-vitiligo–>Ab to melanocyte, congenital-melanoma
What is the difference btwn freckles and lentigines?
freckles depends on sun-exposure and don’t have melanocyte proliferation
How would you describe a seborrheic keratosis?
greasy, “stuck on” appearance, benign
What defines vitiligo? What other diseases should you look for?
- absence of melanocytes-hypopigmentation
- thyroid, DM, pernicious anemia, Addison’s dz
What are therapies for vitiligo?
sunscreen, cosmetics, repigmentation, minigrafting, depigmentation
What is leukoderma?
-hypopigmentation
acquired white spots, but have melanocytes for repigmentation
What is lichen sclerosus? Tx?
- hypopigmentation
- vulva pale and shiny
- clobetasol
What are the hyperpigmentations?
- post-inflammatory–>koebners
- melasma–> pregnancy
- acanthosis nigricans–>dark and velvety in skin folds
What are the types of acanthosis nigricans? Tx?
- 5 types (a/w hereditary, diabetes, obesity, drug, adenocarcinoma)
- tx underlying cause, Retin-A, dermabrasion, abx
What are the erythemas a/w? Txs?
- migrans–> lyme dz…doxycycline
- nodosum–>pre-tibial…strep infections, drugs, idiopathic, fungus, drugs…underlying
- marginatum–>RHF
- multiforme–> target lesions on hands and feet…not much
What are the levels of multiforme? What defines the two worse types?
- minor, intermediate (vestibulocullous), major (SJS), and TEN (max form of SJS)
- SJS usually drug induced 30% epidermis detached, resembles burn
What is lichen planus? tx?
- violaceous
- mucosal membranes with reticular pattern
- 4 Ps: purple, polygonal, pruritic, papules
- steroids
What are the blistering lesions? What is the etiology for both? Tx?
- pemphigus: Nikolsky’s sign, flaccid, IgG to keratinocyte
- pemphigoid: tense, erythema
- etiology: autoimmune
- tx: steroids, immunosuppressants, wound care, abx
What is a sebaceous cyst? How is this different from a lipoma? From a dermatofibroma?
- wall of true dermis contained in dermis, central punctum
- lipoma doesn’t get infected
- dermatofibroma has dimple sign and is button like dermal nodule
What is a pyogenic granuloma? Milium?
- PG: vascular malformation–> blanch w/ pressure (unlike melanoma)
- Milium: small yellow or white keratin containing epidermal cyst
What are precursor lesions to malignant melanoma? What are the types?
- precursor: lentingo maligna, congenital/dysplastic melanocytic nevi
- superficial spreading: most common, horizontal growth then vertical= slow growing
- nodular: arise quickly and grow vertically only
- others are lentigo maligna and acral lentiginous