Dermatology 2 Flashcards
Acne
Pathogenic features
Follicular hyperkeratinization
P. acnes colonization of sebaceous follicle
Inflammation
Increased sebum production
Acne
Subtypes Non-inflammatory
Open comedones – blackheads
Closed comedones – whiteheads
Acne
Subtypes Inflammatory (3)
Pustules – pus with inflammation
Papule – pustules without pus
Nodules – large/deep inflammatory lesions
Acne
Treatment (5) and their MOA
- Benzoyl peroxide – normalize follicular desquamation, reduce inflammatory response, reduce P. acnes
- Topical retinoids – normalize follicular desquamation and reduces the inflammatory response
- Topical antibiotics – reduce inflammatory response and reduce P. acnes
- Hormonal therapy – oral contraceptives and anti-androgens
- Isotretinoin (most potent) – normalize follicular desquamation, reduce inflammatory response, reduce P. acnes, and reduces sebum production
Rosacea
a common skin condition that causes redness and visible blood vessels in your face. It may also produce small, red, pus-filled bumps.
Hidradenitis suppurativa – “acne inversa”
- Hidradenitis suppurativa – “acne inversa” – acne in armpits, groin, under breast, around apocrine glands
- Treatment (antibiotics)
Urticaria
onset, lesion, disease course, histopathology, patho, treatment?
Eczema
onset, lesion, disease course, histopathology, patho, treatment?
Acute Cutaneous Lupus Erythematosus (ACLE) – accompanied with SLE
Photosensitive
Does not scar
Malar/butterfly rash
Subacute Cutaneous Lupus Erythematosus (SCLE)
Photosensitive
Does not scar
Annular plaques (red ring with scale following behind it)
Discoid Lupus
Photosensitive
Scarring
Annular scaly plaques – outer edge is really dark and center collapses and atrophies
May cause alopecia
Dermatomyositis
- Photosensitive
- Heliotrope sign – rashes around the eyes
- Gottron papules – papules on the knuckles or elbows
- Shawl Sign – pink plaque on upper back
Dermatomyositis
sytemic associations
- Pulmonary fibrosis – interstitial lung disease, mechanic’s hands, anti-Jo1 antibodies, Raynaud’s phenomenon (also called anti-synthetase syndrome)
Porphyrias
Excess hair growth in sun exposed areas with blistering and pigmentation
Scleroderma
main syptoms?
Sclerodactyly – thickening/hardening of the skin due to excess collagen production
Scleroderma subtypes?
diffuse, limited, and localized
Diffuse scleroderma
Starts at finger with Raynaud’s phenomenon
Limited Systemic Sclerosis
CREST syndrome – calcinosis cutis, raynaud’s phenomenon, esophageal dysmotility, sclerodactyly, telangiectasia (aka periungal erythema)
Does not progress past elbows and knees
Involves the face
Localized Systemic Sclerosis – also called Morphea
Random sclerotic plaques around the body
Purpura
name 4 types
- Extravasated blood under skin that does not blanch
- Petechiae – small
- Ecchymoses – large
- Non-palpable = macules
- Palpable = papules (associated with small vessel vasculitis)
- Inflammatory
Small vessel vasculitis
Palpable purpura
Medium vessel vasculitis
Stellate (star) purpuric plaques, nodules, ulcers, necrosis
Large vessel vasculitis
No skin findings
Neuropathic Ulcers
Most common in diabetics
Occur over pressure points
Pyoderma Gangrenosum
what should it not be mistaken for?
- Begins as a pustule/cribriform and gets bigger over days (NF gets bigger over hours)
- No systemic illness or pain (NF patients will be septic and tachycardic and feel unwell)
- Avoid debridement (NF requires debridement)
Delusions of Parasitosis
- Self-inflicted ulcers due to attempt to eradicate “parasites”
- Only in areas the patient can reach – patients have large gap on back where they can not scratch
Acanthosis nigricans
- Hyperpigmented velvety plaques in skin
- Commonly associated with insulin resistance (diabetes)
Cushing’s Syndrome
- Elevated cortisol levels, long-term corticosteroid treatment
- Swelling of face and dorsocervical fat pad
Sarcoidosis
- Not erythema nodosum – painful red nodules
- Can be associated with many diseases including pregnancy, IBD, TB, malignancy, medications, and other autoimmune diseases
malar rash - ACLE
SCLE
discoid lupus
Dermatomyositis
Dermatomyositis
Porphyrias
Scleroderma
purpura
SVV
Neuropathic Ulcers
Pyoderma Gangrenosum
Delusions of Parasitosis
Acanthosis nigricans