Dermatological Drugs Flashcards by Destiny Bennett

Bacitracin and Gramicidin treat gram + or gram - strains?

Gram +

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What are examples of bacteria that bacitracin and gramicidin antibacterials can treat?

-Streptococci
-pneumococci
-staphylocci

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Mupirocin antibacterials treat gram + or gram - strains?

Gram +

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What are examples of bacterial strains that Mupirocin can treat?

-Staphylococcus aureus including MRSA

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What are some examples of bacterial strains that Retapamulin can treat?

Streptococci and Staph. aureus (NOT MRSA)

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Does Polymyxin B Sulfate treat gram - or gram + bacteria?

Gram -

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What are some examples of bacterial strains that Polymyxin B Sulfate can treat?

Pseudomonas aeruginosa
E.Coli

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Does Neomycin and Gentamicin treat against gram - or gram + bacterial strains?

Gram -

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What does bacteria does Clindamycin treat?

Propionibacterium acnes (gram +)

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What does Erythromycin treat?

P.acnes

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What does Sodium Sulfacetamide treat?

P.acnes

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What does Metronidazole treat?

Demodex brevis

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What are 5 known antibiotics?

-Clindamycin
-Erythromycin
-Sodium Sulfacetamide
-Dapsone
-Metronidazole

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What are 4 examples of topical antivirals?

-Acyclovir
-Valcyclovir
-Penicyclovir
-Famicyclovir

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What are 6 examples of ectoparasiticides?

-Permethrin
-Lindane (hexachlorocyclohexane)
-Crotamiton
-Sulfur
-Malathion
-Benzyl Alcohol

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What does Permethrin treat?

Mites

What does Lindane treat?

Lice

What does Crotamiton treat?

Scabies

What does Benzyl Alcohol treat?

head lice

What are 4 acne preparations you should know?

-Retinoic acid and derivatives
-Isotretinoin
-Benzoyl Peroxide
-Azelaic Acid

What acne preparation is essentially “acidic vitamin A”?

Retinoic acid

What acne preparation is an analogue of vitamin A?

Isotretinoin

What pro-inflammatory cytokines are released during psoriasis?

-IFN- gamma
-IL-23
-IL-17
-IFN- Alpha

What are the 4 drugs used for treating psoriasis?

-Acitretin
-Tazarotene
-Calcipotriene
-Calcitriol

What drugs for psoriasis are retinoids, and vitamin A derivatives?

-Acitretin -Tazarotene

What drugs for psoriasis are related to Vitamin D?

-Calcipotriene -Calcitriol

What biologics are used to treat psoriasis?

-Alefacept -TNF Inhibitors (Etanercept, Infliximab, Adalimumab) -Ustekinumab (IgG antibody)

What biologics are used to treat psoriasis?

-Alefacept -TNF Inhibitors (Etanercept, Infliximab, Adalimumab) -Ustekinumab (IgG antibody)

Are biologic agents naturally occurring or are they synthetically made?

Naturally occuring

What effect does Alefacept have on the immune system?

-It is an immunosuppressant -Stops the activity of T lymphocytes

How is Alefacept administered?

Intramuscularly

How does Etanercept work?

It acts as a decoy receptor for TNF-Alpha. Etanercept receptors will become saturated so normal TNF-Alpha receptors do not. Thus, decreasing inflammation

How does Infliximab and Adalimumab work?

They bind directly to TNF-Alpha receptors

How do corticosteroids work?

They induce the synthesis of IkBa, a protein that traps and inactivated NF-kB

What does NF-kB do?

It is an activator of cytokine genes and mediator of the proinflammatory action of TNF and IL-1

What are 2 antipruritic agents?

-Doxepin -Pramoxine

What do Trichogenic agents do?

They are hair producing agents

What are 4 trichogenic and antitrichogenic agents

-Minoxidil -Finasteride -Bimatoprost -Eflornithine