Dermatitis and Eczema Flashcards

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1
Q

Key Learnings of Irritant Contact Dermatitis

A

-Most common
-From freq’ exposure to chemicals or substance which damage the skin (water, soaps, detergents, dribbling)
-Chronic stages present as: very dry thickened, cracking

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2
Q

What is ‘Napkin Dermatitis’?

A

-A subcategory of irritant contact dermatitis (can be atopic also)
-Very common in infant and toddlers - “Nappy Rash”
-can be complicated by secondary candida infection

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3
Q

Describe key features of contact dermatitis

A
  • True allergy
    -Patch test to confirm allergy
    -Occurs in unusual patterns related to allergen contact
    -Can extend past contact area
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4
Q

What are some common examples of causes of Allergic Contact Dermatitis?

A

Bandaids, watch band, plant contact, rubber gloves, nickel in earrings, jean stud on abdomen

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5
Q

Describe the key feature of Asteatotic dermatitis

A

-Common in ELDERLY
-Characterised by very dry flaking skin which splits - “crazy-paving’ appearance
-Particularly effects lowers legs
-Worse in winter (low humidity) and worsened by soap and household heating.

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6
Q

Describe the key features of Atopic Dermatitis (a.k.a Eczema)
Who, why, what, when?

A

-Common in infancy/childhood
-Genetic Predisposition
-Worse in winter (relapsing, chronic condition)
-RED, SCALY ERUPTION, can be weeping and crusted in acute phase
- Flexures and cheeks
-Intense itch and rubbing which exacerbates condition and becomes resistant to treatments
-Prone to skin infections (strep and staph)
-Antibiotics often required initially

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7
Q

Describe discoid dermatitis key characteristics

A

-Common in young to middle-aged
-Round, disc-like scaling lesions -intensely itchy
-clearly demarcated edges
-Can be confused with ringworm
- acute and weeping, commonly secondary infection
-Occurs on trunk and limbs

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8
Q

Describe key feature of dyshydrotic/pompholyx presentations of dermatitis:

A

-Common in young people
-characterised by lines of small vesicles (blisters with clear fluid)
-Blisters=intensely itchy, maybe burning feeling, sore
-Exudate when burst
-Pompholyx is a severe form of dyshydrotic
* Peeling flaking skin and vesicles
*similar appearance to fungal infections
-Connected to STRESS

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9
Q

Describe the key features of Seborrheic Dermatitis

A

(to be updated)

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10
Q

How can we differentially diagnose between tinea and psoriasis (and dermatitis)?

A

Tinea (ringworm) = has an active outer, red scaling edge and CLEARING centre (kind of like a blursed fairy circle of ew). Psoriasis presents as thicker pinky red plaques with a silvery scale that can be throughout the whole plaque, not just edges. Doesn’t have blisters. Is commonly located on extensor (external side) of knees and elbows. Dermatitis is less thick and more so found on flexures and trunk.

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11
Q

Which one of the following options best describes atopic eczema?
a) mostly caused by allergy due to contact with some substance or chemical in the environment
b) It is intensely itchy and has a genetic predisposition
c) Is an exogenous form of dermatitis

A

b) It is intensely itchy and has a genetic predisposition

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12
Q

Which one of the following best applies to asteototic eczema?
a)Intensely itchy, raised, erythematous scaling lesions
b) Often confused with tinea corporis (ringworm)
c) Most common in elderly, particularly on lower legs
d) Characterised by round, disc-like lesions
e) Often occurs with young people and connected to stress

A

Asteototic eczema is most common in elderly, particularly on lower legs.
It’s giving lizard people. I don’t want to get older.

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13
Q

Which one of the following best applies to pompholyx / dyshidrotic eczema?

a) Most common in elderly, particularly on lower legs
b) Characterised by round, disc-like lesions
c) Often occurs with young people and connected to stress

A

c) Often occurs with young people and connected to stress - and I swear if I get these this painful, itchy exudate filled blisters from uni stress I will throw handdssss ( which will probably now hurt )

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14
Q

Which one of the following is the most characteristic, and potentially MOST distinguishing, symptom of eczema?

a) Cracks in the skin
b) Redness
c) Itch
d) Scaly texture
e) Weeping

A

c) itch

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15
Q

List some Non-Pharmacological treatment options and advice for dermatitis and eczema:

A
  • Avoid precipitating factors
    -Avoid scratching
    -Bath every 2nd day
    -Pat skin dry, don’t rub
    -keep skin cool
    -Occlusion or wet dressing
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16
Q

List some OTC/S3 treatment options and advice for dermatitis and eczema:

A

-Use soap substitutes
-Emollients/moisturisers (best straight after washing)
-Antihistamine
-Tar/ichthammol
-Topical corticosteroids
(Hydrocortisone 0.5 and 1%, Clobetasone, Mometasone furoate 0.1%)
-Probiotics (research varies)
-Colloidal oatmeal!

17
Q

List some options for prescription treatments in management of dermatitis/eczema:

A

-Compounded Coal tar
-Potent Topical corticosteroids
-Antibiotics (if infection present)
-Biological Agents
-Calcineurin inhibitors
*Crisaborole (brand name = Staquis)
-Oral immunosuppressants agents - failure to control with topical agents

18
Q

Why do we use antihistamines in management of dermatitis and eczema and which class?

A
  • To reduce itch
  • Sedating class recommended
19
Q

Key information of Tar preparations:

A
  • Liquid Coal Tar (LPC), Pine Tar, Ichthammol
    -Exact mechanism unknown; reduce epidermal thickmess, antipruritic(relieve itching)/antiseptic
20
Q

Provide the key features of topical corticosteroids (generally) in treatment of skin conditions such as dermatitis and eczema:

A
  • Acts to relieve itching, redness and inflammation
    -Avoid if uncertain diagnosis
    -Chose a potency appropriate to site and severity
    -Use an appropriately potent product for the shortest time necessary to control skin disorder (i.e. resolution)
21
Q

Hydrocortisone (DermAid®, Sigmacort®, 0.5-1%, varied scheduling). What, who, and how often?

A

-Mildly potent topical corticosteroid to treat ‘flare ups’ of dermatitis.
-Also available combined with antifungals or local antihistamines
-Applied to the affected area/s up to tds

22
Q

Clobetasone (Eumovate® 0.05%, S3)
What and how often?

A

-More potent topical corticosteroid than hydrocortisone.
-Used in mod-severe ‘flare-ups in dermatitis and eczema
-Apply bd to affected area

23
Q

Mometasone furoate (Zatamil®, 0.1% hydrogel or ointment, S3)

A

-Apply od to affected area/s
-Stronger than eumovate and hydrocortisone
-Was in recent years prescription only, now 1x 15g tube available S3

24
Q

Discuss generally corticosteroid potency in relation to presentation and demographic

A

Low-potency steroids are the safest and most suitable for large surfaces, on thinner skin, and on children.
More potent steroids are beneficial for thicker skin or severe presentations (prescribed).

25
Q

What is the number of adult FTUs required to apply each dose to an adult for the
-neck and face
-chest and abdomen (combined)
-back and buttocks (combined)
-per hand
-Per leg
-per foot

A
26
Q

PBS Prescription treatment for Atopic Dermatitis: Calcineurin inhibitor - Pimecrolimus cream (Elidel® 1% 15g).
-Who?
-How does it work?
How often to apply?

A

-Second line treatment in for facial atopic eczema if topical corticosteroids are C/I or ineffective
-PBS - have to be OVER 3 Y/O
- Non-steroid inhibitor of inflammatory cytokines, believed to block T cell activation, and thus prevent inflammatory mediator release from mast cells
- Applied BD (3-6 weeks dependant on age)
-SUN PROTECTION

27
Q

NON PBS Prescription treatment for Atopic Dermatitis:
Crisaborole (Staquis®)
-How does it work?
-Who is it for?
-How long can it be used for?

A

PDE-4 inhibitor (anti-inflammatory - reduces secretion of certain cytokines)
-Indication: mild - mod atopic dermatitis in patients >2 y/o
-No comparative trials with topical corticosteroids
-Ca be used up to 28 days per treatment course

28
Q

Name 5 of the immunosuppressants that can be used off-label (not very often) for atopic dermatitis where topical agents failed?

A

-Methotrexate
-Ciclosporin
-Prednisolone
-Azathioprine
-Mycophenolate

All oral therapies.
Act to modulate the immune system to take away the immune response that causes atopic eczema.

29
Q

What are the 3 biological agents that may be used in Atopic Dermatitis?

A

-Dupilumab (Dupixent®): Subcut injection
targets underlying immunological cause

-Upadacitinib (Rinvoq®):
-Baricitinib (Olumiant®):
Both daily oral therapies that are Janus Kinase (JAK) inhibitors

30
Q

List treatment options specific to: Allergic Contact Dermatitis

A

Avoid irritant/allergen

Topical corticosteroid

Severe/acute – may require oral corticosteroids

31
Q

List treatment options specific to Irritant Contact Dermatitis

A

Avoid irritant/allergen

Topical corticosteroid

Severe/acute – may require oral corticosteroids

32
Q

List treatment options specific to: Atopic Dermatitis/Eczema

A

Soap substitutes

Emollients/moisturisers

Topical corticosteroid

Severe – see immunosuppresants (off-label), biological agents

Topical pimecrolimus or crisaborole

Tar preparations

33
Q

List treatment options specific to: Discoid Dermatitis

A

If infected – oral antibiotics

Topical corticosteroids

With/without modified dressing

34
Q

List treatment options specific to:
Dyshidrotic/Pompholyx Dermatitis

A

Bathe in salt water (help dry up vesicles)

Topical corticosteroids

Severe/acute – may require oral corticosteroids

35
Q

List treatment options specific to: Asteatotic Dermatitis

A

Soap substitutes

Emollients/moisturisers

Topical corticosteroids

36
Q

Which one of the following topical corticosteroids is NOT moderately potent?

a) Clobetasone 0.05%
b) Clobetasol 0.05%
c) Betamethasone valerate 0.02%
d) Betamethasone valerate 0.05%
e) Triamcinolone 0.02%

A

b) Clobetasol 0.05%

37
Q

List some key referral points in Dermatitis:

A

-If a secondary bacterial infection exists​

-Serious underlying diseases (e.g. diabetes)​

-Large/extensive area/s, moist and/or bleeding​

  • Patch testing if allergen not obvious for allergic contact dermatitis

-Confirming non-fungal before supplying OTC S3 topical steroid (the fungus will remain unresolved and may significantly worsen​)