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HPIM 19th Derma > Derma > Flashcards

Derma Flashcards

1
Q

Pathognomonic sign of Scleroderma

SLE, DerMatomyositis

A

Periungual Telangiectasia

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2
Q

Most common of all drug reactions

A

Morbilliform

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3
Q

Second most frequent type of cutaneous reaction to drugs

A

Urticaria

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4
Q

Associated with red man syndrome

A

Vancomycin

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5
Q

Blisters developing on target lesions with mucosal involvement with TBSA detachment <10%

A

SJS

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6
Q

TBSA >30% mucosal/epidermal detachment

A

TEN

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7
Q

Detachment of the DISTAL part of the nail plate

A

Onycholysis

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8
Q

Detachment of the PROXIMAL part of the nail plate

A

Onychomadesis

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9
Q

Mucosal involvement and target lesions associated with HSV

A

Erythema multiforme

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10
Q

Poor prognosis in SJS/TEN

A

Intestinal and pulmonary involvement

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11
Q

Cytologic technique most often used in the diagnosis of HSV or VZV

A

Tzanck smear
(presence of multinucleated epithelial giant cells)

Lesion examined: early vesicle

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12
Q

“Apple Jelly” on diascopy

A

Granulomas

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13
Q

Ash leaf spots on Wood’s light

A

Tuberous Sclerosis

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14
Q

Clinical Features if Atopic Dermatitis

A
  1. Pruritus and scratching
  2. Exacerbations and remissions
  3. Typical lesions of eczematous derm
  4. Personal or Fam Hx of Atopy
  5. > 6 weeks
  6. Lichenification
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15
Q

Prominent characteristic of AD in all age groups

A

Pruritus

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16
Q

Common histologic finding of eczema

A

Spongiosis

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17
Q

Mutation gene associated in AS

A

Filaggrin

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18
Q

MC type of ICD

A

Chronic low-grade irritant dermatitis

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19
Q

MC area of involvement of ICD

A

Hand

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20
Q

MC cause of ACD

A

Exposure to plants (Urushiol)

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21
Q

Immune-mediated disease characterized by erythematous, sharply demarcated papules and rounded plaques covered by silvery micaceous scale

A

Psoriasis

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22
Q

Traumatized areas develop lesions of psoriasis

A

Koebner phenomenon

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23
Q

MC variety of psoriasis

A

Plaque-type

stable, slowly enlarging plaques, which remain unchanged for long periods of time

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24
Q

Psoriasis common in children and young adults

A

Guttate/eruptive psoriasis

frequently after an URTI with GBHS

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25
Q

Pruritic, polygonal, flat-topped, violaceous papules

A

Lichen planus

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26
Q

Network of gray lines on the surface of lichen planus

A

Wickham’s striae

27
Q

Associated with LP

A

Hepatitis C infection

28
Q

Clinical hallmark if acne vulgaris

A

Comedone

29
Q

MC location for acne

A

Face

30
Q

Bacteria responsible for acne vulgaris

A

Proprionobacterium acnes

31
Q

Characterized by erythema, telangiectases, superficial pustules

A

Acne rosacea

32
Q

Characterized by discrete lesions, most often found on the face, scalp and/or external ears

A

Discoid Lupus Erythematosus

33
Q

Lesion specific for DLE

A

“Carpet tacking”

34
Q

MC location of stasis dermatitis

A

Lower extremities, usually medial aspect of the ankle

35
Q

Represents a large proportion of cases of occupation-associated skin disease

A

Hand eczema

36
Q

Transient lesions that are composed of a central wheal surrounded by an erythematous halo or flare

A

Urticaria

37
Q

Linear wheals following minor pressure or scratching of the skin

A

Dermatographism

38
Q

Subcutaneous edema

A

Angioedema

39
Q

Sensation that elicits the desire to scratch

A

Pruritus

40
Q

Systemic conditions associated with pruritus

A 
CKD
cholestasis
pregnancy
CA
Thyroid disease
PV
delusions of parasitosis
41
Q

Performed on scaling lesion where fungal etio is possible

A

KOH (10-20%)

KOH dissolves KERATIN, brief heating accelerates keratin dissolution

42
Q

Identified by KOH

A

hyphae:dermatophyte

pseudohyphae and budding yeast:Candida

fragmented hyphae and spores:tinea versicolor

43
Q

MCC of Drug-induced Hypersensitivity Syndrome (DIHS)

A

Allopurinol

44
Q

Outer layer of epidermis separates readily from basal layer with lateral pressure

A

TEN

necrotic epidermis

45
Q

Cutaneous reactions in DIHS

A

Begins 2-8 weeks after the drug is started and lasts longer than mild eruptions after drug cessation

46
Q

Complications of DIHS

A

late-onset autoimmune thyroiditis

47
Q

Not associated with Eosinophilia in DIHS

A

Lamotrigine
Abacavir
Dapsone

48
Q

Second most frequent type of cutaneous reaction to drugs

A

Urticaria

49
Q

Most frequent causes of urticaria

A 
ACEI
Aspirin
NSAIDS
Penicillins
blood products
50
Q

Three mechanisms of Urticaria/Angioedema/Anaphylaxis

A

IgE dependent mechanism
Circulating immunce complexes
Non-immunologic activation

51
Q

Group of autoantibody-mediated intraepidermal blistering diseases characterized by loss of cohesion between the epidermal cells (acantholysis)

A

Pemphigus

52
Q

Manual pressure to skin elicits separation of the epidermis

A

Nikolsky sign

53
Q

MC cutaneous manifestation in dermatomyositis

A

Heliotrope rash

purple-red discoloration of the upper eyelids sometimes assoc with scaling or periorbital edema

54
Q

Pathognomonic of dermatomyositis, flat-topped papules over the dorsal interphalangeal joints

A

Gottron’s papules

55
Q

Thin violaceous papules and plaques on the elbows and knees of dermatomyositis

A

Gottron’s sign

56
Q

Distinguishes dermatomyositis from SLE and SS

A

Poikiloderma

57
Q

Autoantibodies present in Subacute cutaneous lupus erythematosus (SCLE)

A

anti-Ro

58
Q

Treatment for SCLE

A

Aminoquinoline antimalarials

59
Q

Seen when there is an extravasationnof RBCs into the dermis, lesions DO NOT blanch with pressure

A

Purpura

60
Q

Dermal edema

A

Urticaria

61
Q

Urticaria precipitated by heat, excercise or emotion

A

Cholinergic urticaria

62
Q

Honey-colored crusts

A

Bullous impetigo

63
Q

Scarlatiniform exanthem

A

Scarlet fever

HPIM 19th Derma (1 decks)

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