Derm systemic meds Flashcards

DCNP

1
Q

Cyclosporine start labs

A

-two baseline BPs at least a day apart
-CBC w/ diff & CMP
-Two baseline creatinine level (or Cr clearance) at least a day apart

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2
Q

Cyclosporine contraindications

A

-CTCL
-abn renal function
-uncontrolled HTN
-malignancies
-radiation therapy or concomitant PUVA/UVB
-MTX or immunosuppressives

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3
Q

Cyclosporine pregnancy

A

Category C; new 2015 rating; probably compatible

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4
Q

Cyclosporine warnings

A

-nephrotoxicity, hepatotoxicity, serous infections, transplantation patients (^malignancy)
-HTN, usually mild and generally reversible after dose reduced or d/c

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5
Q

Corticosteroids contraindicated

A

-systemic fungal infections, hypersensitivity
-live vax shouldn’t be given

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6
Q

Corticosteroids >4 weeks

A

-DEXA scan, Vit D 800 IU, calcium 1,200 mg, biphosphonates
- >1 gm total dose H2 antihistamines or PPIs

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7
Q

MTX absolute C/I

A

-ETOH abuse, bone marrow d/o, CKD, liver dz, immuondeficiency syndromes, patients contemplating pregnancy and lactation

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8
Q

MTX drug interactions HIGH risk

A

sulfonamides (dapsone),sulfamethoxazole (TMP/SMX), phenytoin, phenothiazine, NSAIDs, immunosuppressants, oral retinoids

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9
Q

MTX drug interactions LOWer risk

A

tetracyclines, cholestyramine, live vax

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10
Q

MTX warnings

A

-complete vax (live or recombinant) 2 wks before initiation of treatment
-monitor for preg/BF
-screen/monitor for infection
-assessment of ETOH intake

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11
Q

MTX adverse effects

A

Hepatotoxicity, aplastic anemia, pancytopenia, GI sx (diarrhea, stomatitis, intestinal perforation), opportunistic or reactivation of infections, secondary malignancies. MTX pneumonitis (usu. in first 6 mons dry cough, SOB)

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12
Q

MTX labs

A

Baseline: CBC w/ diff, liver/renal fxn, screen Hep B/C, TB, HIV if indicated

Follow-up: CBC & LFTs 1 wk after test dose, then q1-2 wks for month, then q3-4mons, renal fxn 1-2 yearly

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13
Q

MTX liver evaluation

A

Baseline only if high-risk (NASH, obesity, HLD)
1st bx 3.5-4 g total cumulative

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14
Q

General biologics guidelines

A

-baseline screen for infections (Tb, Hep B/C, HIV)
-don’t use on pts w/ acute/chronic infection
-avoid all live vax during tpy
-d/c if hypersensitivity, or serious infections

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15
Q

Biologics: special pops

A

-Hepatitis B, eval by GI spec
-Hep C, confirmed and resolved (may use anti-TNF, monitor for reactivations)
-Preg/lact, greatest r/o placental transfer 3rd tri; anti-TNF safest certolizumab pegol
-Etanercept ages 4 and older
-don’t use MTX, acetretin & top tazarotene, C/i preg

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16
Q

Biologics: Target specific safety issues

A

TNFa inhibitors: TB, NYHA III/IV HF, lupus, MS
IL-17 inh: candida infections, IBD
IL-12/23 ustekinumab (Stelara): exfoliative dermatitis
IL-23 p19: none

17
Q

Antivirals therapeutic recommendations
(acyclovir, valacyclovir, famciclovir)
indications for HSV & HZ

A

-may cause nephrotox (intratubular precipitation of crystals)
- ^ risk if dehydration or pre-exis renal impairment
-f/u vax should be delayed at least 2 wks p antiviral tpy

18
Q

Zoster antiviral dosing

A

acyclovir: 800 mg 5x/day x 7-10 d
valacyclovir*: 1 g TID x 7-10 d
famciclovir: 500 mg TID x 7d

19
Q

HSV primary episode

A

acyclovir: 400 mg TID x 10 d
valacyclovir: 1 g BID x 10 d
famciclovir: 250 mg TID x 10d

20
Q

Itraconazole contraindication

A

ventricular dysfunction (CHF)

21
Q

Oral ketoconazole

A

black box warning: serious hepatoxoticity
QT Prolongation

22
Q

Oral terbinafine

A

AE rare but severe neutropenia and noted smell and taste disturbance

23
Q

MRSA susceptible abx

A

clindamycin, bactrim, tetracycline

24
Q

Tetracyclines

A

-risk of pseudotumor cerebri alone or w/ isotretinoin, SJS/TEN, GI upset, esophagitis, vaginal candidiasis
-MCN: vestibular SE more common first few doses >F, dyspigmentation, DRESS, lupus-like syndrome, vasculitis

25
Q

Dapsone caution

A

-genetic deficiency of enzyme> G6PD (glucose-6-phosphate dehydroxygenase) causes increased hemolysis

26
Q

Dapsone monitoring

A

-CBC w/ diff, weekly x 1st month, then q2 wks x 2 mons, then q3-4 mons (hemolytic anemia predictable almost all pts, drop in hgb)
-LFTs, renal fxn & UA q3-4 mons

27
Q

Dapsone drug interactions

A

bactrim, MTX, colchicine, anticonvulsants, griseofulvin

28
Q

Hydroxychloroquine patient ed

A

-risk for blue-gray discoloration of skin
-smoking cessation
-induction or exacerbation of Pso

29
Q

Hydroxychloroquine dose/monitor

A
  • ukn MOA, max dose 6.5 mg/kg/day ideal body wt (or 5mg/kg/d on actual body weight)
    -Baseline CBC w/diff, CMP, sometimes G6PD
    -Retinal tox: baseline then q 5 yrs; then 1-2 yrs; more often if high doses or elderly
30
Q

Pseudotumor cerebri

A

Headaches that start behind your eyes or in the back of the head. Blurry vision, double vision. Blackout in vision. N/V. sx worse w/ exercise.

31
Q

Spironolactone (caution)

A

-hyperkalemia: ^ risk w/ ACEs, ARBs, drospirenone, high K food/supp
sx high K: muscle cramps, weakness, muscle fatigue & paresthesias, cardiac irreg

32
Q

Acitretin contraindications

A

Pregnancy, liver or kidney impairment, chronic concomittant MTX and TCN.
Females don’t get pregnant x 3 years

33
Q

Acitretin drug interactions

A

MTX, cyclosporine, TCN & macrolide abx, ETOH, griseofulvin, rifampin, anticonvulsants, progestin only and COC

34
Q

Acitretin Serious SE

A

high TG, hypercholesterolemia, ^LFTs and pancreatitis, pseudotumor cerebri, leukopenia and agranulocystosis, skeletal hyperostosis, myopathy, hypothyroidism, DM

35
Q
A