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MSK II Exam II > Derm Pharm Crossword (Wolff) > Flashcards

Derm Pharm Crossword (Wolff) Flashcards

1
Q

Peptide antibiotic with efficacy against gram-negative bacteria including pseudomonas, has a detergent -like effect that damages the bacterial membrane

A

polymixinb

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2
Q

Agents such as iodine, chlorohexidine, and hydrogen peroxide potentially do this to wound healing

A

impede

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3
Q

forms on surfaces, very hard to kill because resident microbes of different species help eachother survive

A

biofilms

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4
Q

inhibits the mutated BRAF V600D MAP kinase found in ~60% of melanomas

A

vemurafenib

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5
Q

type of dressing useful for the granulation stage of wound repair

A

foam

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6
Q

lower, closer to that of skin is why synthetic detergents minimize skin irritation during home skin care

A

pH

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7
Q

photosensitizer administered in conjunction with UVA treatment of psoriasis

A

psoralen

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8
Q

topical therapy for treating herpes labialis (also used systemically for herpes infections at other sites)

A

acyclovir

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9
Q

urea, alpha-hydroxyl acids, and allantoin are among the agents found in moisturizers to soften this and give skin a smoother feeling (2 words)

A

horny substance

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10
Q

has 7 potency classes for topical administration so that it is possible to taper down to the lowest dose needed to control inflammation; administered systemically to control pain and inflammation of rheumatoid arthritis until DMARD effects manifest; can also be injected directly into inflamed joints

A

glucocorticoids

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11
Q

can be useful therapies for neuropathic pruritis

A

local anesthetics

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12
Q

opioid receptor antagonist that can treat the pruritis associated with chronic kidney disease and cholestasis

A

naltrexone

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13
Q

delayed hypersensitivity reaction that can be caused by substances such as latex and drugs such as neomyicn and bacitracin; sometimes induced as treatment of skin disorders (e.g. psoriasis, allopecia) (2 words)

A

contact dermatitis

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14
Q

treatment for actinic keratoses derived from Euphorbia peplus sap, causes chemoablation with neutrophil-mediated antibody dependent cellular cytotoxicity eliminating remaining tumor cells (2 words)

A

ingenolmebutate

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15
Q

broad-spectrum antimicrobial agent widely used in homes and hospitals due to efficacy on skin and oral mucosa with low irritability

A

chlorhexidine

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16
Q

to heal best, wounds should be kept clean and ___

A

moist

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17
Q

K+ sparing diruetic with partial agonist properties at androgen receptors that can make it useful for treating menstrual cycle-linked acne or male pattern baldness in adult women

A

spironolactone

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18
Q

cyclosporine and tacrolimus are among these agents that revolutionized transplantation therapy ( didn’t cause bone marrow suppression), among other uses includes topical or systemic administration for psoriasis and topical administration for anogenital pruritis (2 words)

A

calcineurin inhibitors

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19
Q

treatment for allopecia, it is a contact allergen applied to cause dermatitis which can be followed by hair growth

A

DPCP

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20
Q

most important component of infection control (2 words)

A

hand hygiene

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21
Q

among the imidazole drugs commonly used to treat vulvovaginal candidiasis

A

miconazole

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22
Q

orally active phosphodiesterase type IV inhibitor that inhibits numerous pro-inflammatory mediators, used in moderate-to-severe plaque psoriasis and psoriatic arthritis; severe diarrhea is adverse effect

A

apremilast

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23
Q

drug class that may (e.g. for urticaria) or may not stop the itch, but the associated drowsiness may help one deal with it

A

antihistamines

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24
Q

alpha adronergic agonist in Visine known for its ability to “get the red out”

A

tetrahydrozoline

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25
Q

titanium dioxide is an example that could be applied, for example, to your nose when on the beach

A

sunshade

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26
Q

among OTC drugs (e.g. Tinactin) used to treat jock itch and athletes foot; like terbinafine, inactive against yeasts

A

tolnaftate

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27
Q

itching here is less funny than it sounds, topical calcineurin inhibitors such as tacrolimus can help treat

A

anogenital

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28
Q

local vasoconstriction due to blood volume deficit, unrelieved pain, hypothermia, etc. can impair wound healing due to an inadequate amount of this in teh tissue

A

oxygenation

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29
Q

imidazole antifungal drug applied topically for range of fungal infections, also noteworthy as a classic inhibitor of cytochrome P450

A

ketoconazole

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30
Q

potent vasodilator due to hyperpolarozation via activation of K+ channels, applied topically to grow hair

A

minoxidil

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31
Q

tetracycline used to treat acne, noteworthy for its ability to cause dark pigmentation in skin and sclera

A

minocycline

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32
Q

component of plant defenses against bacteria, active against P. acne, (2 words)

A

azaleic acid

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33
Q

macrolide among the systemic therapies used to treat acne; noteworthy because it is not a cytochrome P450 inhibitor, has unusual pharmacokinetics in that it is taken up in phagocytes and released by them at sites of infection

A

azithromycin

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34
Q

topical antimicrobial agent commonly used to treat acne; local skin irritant and may bleach hair or clothing (2 words)

A

benzoyl peroxide

35
Q

very important component of skin care for health care providers

A

moisturizers

36
Q

organophosphate anticholinesterase insecticide, kills ectoparasites

A

malathion

37
Q

topical immune response modifier used to treat actinic keratoses and basal or squamous cell carcinomas; also used to treat genital warts

A

imiquimod

38
Q

substance P antagonist used to treat nausea and vomiting of chemotherapy, also useful to treat intense itching of cutaneous T-cell lymphomas (Sezary syndrome)

A

aprepitant

39
Q

antibiotic that works similar to macrolides, kills anaerobes, useful for range of infections including topical treatment of acne and for osteomyelitis; associated with increased risk of C. difficile

A

clindamycin

40
Q

synthetic insecticide similar to that of chrysanthemums, ectoparasite therapy (Nix) that binds to insect Na+ channels and prevents membrane repolarization

A

permethrin

41
Q

an oral hedgehog signaling pathway inhibitor used to treat advanced basal cell carcinoma

A

vismodegib

42
Q

refers to substances in moisturizers that form an oily later to trap in the skin; petrolatum, lanolin, and mineral oil are among common examples

A

emollients

43
Q

kappa-opioid receptor agonist/ mu-opioid receptor antagonist administered intranasally to treat intractable/nocturnal pruritis

A

butorphanol

44
Q

example of a systemic imidazole therapy to treat tinea versicolor

A

fluconazole

45
Q

blocks the conversion of testosterone to more potent androgen dihydrotestosterone, among its uses is to treat male pattern baldness in men and second-line agent for this in women

A

finasteride

46
Q

biologic DMARDs, also administered systemically to treat other autoimmune diseases such as psoriasis

A

TNF-alpha blockers

47
Q

this typically happens a few days after an attack of gouty arthritis if untreated

A

resolves

48
Q

orally administered insecticide to treat ectoparasites, binds glutamate-activated Cl- channels to hyperpolarize the nerve and muscle cells

A

ivermectin

49
Q

biologic DMARD directed against IL-17a, used to treat psoriasis and psoriatic arthritis and, for some, works much better than anti-TNF therapies

A

sekucinumab

50
Q

sometimes need to resort to things such as Unna boots in the category to try to break the itch-scratch cycle

A

physical interventions

51
Q

can be effective treatment for acne in women (2 words)

A

oral contraceptives

52
Q

~50% water and 50% oil with an emulsifier, base that is useful for covering large and/or wet areas with a drug but preservatives, etc., can cause allergic reactions

A

creams

53
Q

anti-inflammatory agent known since ancient times, keratolytic effects due to its ability to dissolve intercellular cement makes it useful for treatment of acne, dandruff, and calluses (2 words)

A

salicylic acid

54
Q

refers to agents such as glycerin, lecithin, and propylene glycol found in moisturizers to draw water into the outer layer of skin

A

humectants

55
Q

active ingredient of vulvovaginal medications for candidiasis

A

clotrimazole

56
Q

can be administered systemically to treat tinea capitis (ringworm in scalp)

A

griseofulvin

57
Q

very old remedy for psoriasis; works but color and smell create a challenge

A

tar

58
Q

drug class useful for systemic treatment of acne, photosensitivity, GI distress and contraindication in pregnancy and young children due to gray discoloration of permanent teeth are noteworthy adverse effects

A

tetracycline

59
Q

FDA-approved conventional treatment for melanoma

A

dacarbazine

60
Q

important component of wound healing, it conserves the local resources by limiting the need to synthesize proteases; stage when hydrogels are good wound covering

A

debridement

61
Q

class of antifungal drugs with a wide range of activity, blocks ergosterol synthesis

A

imidazoles

62
Q

common cause of diarrhea due to antibiotic-associated colitis, well know example where handwashing with soap and water is sperior to alcohol-based gels

A

C. difficile

63
Q

antifungal agent with topical effects limited to candida infections, may temporarily stain the skin yellow (also administered IV, etc., for other fungal infections as well including aspergillus and endemic mycosis)

A

amphotericin B

64
Q

alpha2-agonist administered topically as a gel to treat rosacea

A

brimonidine

65
Q

the formation of one of these for a drug in the skin may prolong its half-lie and permit 1/day dosing

A

reservoir

66
Q

comprised of ~20% water and 80% oils, best for dry skin, stay on the surface of skin and are not well absorbed, permit more complete adrug absorption and less likely to cause allergic reaction, no preservatives

A

ointments

67
Q

blocks enzyme needed for ergosterol synthesis; useful topically for fungal infections such as jock itch and athlete’s foot and systemically for fungal nail infections

A

terbinafine

68
Q

class of adrenergic agonists administered topically to treat rosacea or red eyes

A

alpha

69
Q

antifungal applied topically that penetrates into nails to treat fungal infection

A

efinaconazole

70
Q

topical retinoid administered for the treatment of acne, alters gene expression to normalize keratinization, decrease keratinocyte cohesiveness and reduce microcomedone formation

A

tretinoin

71
Q

when used to treat thrush, it is held in the mouth before swallowing (has negligible GI absorption)

A

nystatin

72
Q

macrolide antibiotic, among uses is for topical or systemic treatment of acne; among the well known cytochrome P450 inhibitors to remember

A

erythromycin

73
Q

prescription synthetic topical antimycotic agent with broad spectrum of activity against fungal skin infections such as ringworm, athlete’s foot, tinea versicolor, dandruff

A

ciclopirox

74
Q

control that is now considered a priority for optimal wound closure

A

glycemic

75
Q

effective topical therapy for actinic keratoses, causes fast-proliferating dysplastic cells to die a thymidine-less death; necrosis/erosion gives way to re-epithelialization over several weeks

A

5-fluorouracil

76
Q

antiepileptic drug used to treat neuropathic pain and itching

A

gabapentin

77
Q

late choice for treating ectoparasites, works by disrupting GABAergic transmission

A

lindane

78
Q

retinoid administered orally for treatment of severe acne, powerful teratogen that mandates participation by young females in the iPledge program

A

isoretinoin

79
Q

peptide antibiotic with activity against gram-positive organisms and some anaerobes; only applied topically to limit systemic toxicity, often causes contact dermatitis

A

bacitracin

80
Q

monoclonal antibody against IL-12 and IL-23, a biologic agent used to treat psoriasis

A

ustekinumab

81
Q

aminoglycoside antibiotic of Neosporin with activity against gram-negative bacteria

A

neomycin

82
Q

platelet-derived growth factor that promotes the cell proliferation and angiogenesis needed for diabetic ulcer repair, but must use cautiously as too much increases risk of malignancy

A

becaplermin

83
Q

prototypical non-steroid androgen antagonist, uses besides prostate cancer include treatment of male pattern baldness in women

A

flutamide

84
Q

radiation that may not cause erythema and sunburn but nevertheless still does contribute to skin aging and photocarcinogenesis

A

UVA

MSK II Exam II (4 decks)

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