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SBL Exam 2 > Derm Pharm > Flashcards

Derm Pharm Flashcards

1
Q

platelet derived growth factor

promoting cell proliferation & angiogenesis

A

Becaplermin

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2
Q

only agent approved for chronic diabetic foot ulcers

A

Becarplermin

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3
Q

peptide antibiotic
inhibit bacterial cells wall synthesis
active against gram-positive organisms

A

bacitracin

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4
Q

aminoglycoside antibiotic bind to 30S ribosomal subunit
active against gram-negative
causes allergic dermatitis
poorly absorbed through skin

A

neomycin

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5
Q

peptide antibiotic binds to phosphor-lipids to alter permeability
effective against gram-negative
rarely causes allergic reaction

A

polymixin B

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6
Q

topical application as cream or lotion for use in vulvovaginal candidiasis

A

miconazole &clotrimazole

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7
Q

for onchomycosis

A

efinaconazole

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8
Q

cream for dermatophytosis & candidiasis, shampoo or foam for seborrheic dermatitis

A

ketoconazole

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9
Q

prescription synthetic broad-spectrum topical antimycotic agent
activity against dermatophytes, Candida & Malassezia
low incidence of adverse reactions and contact dermatitis

A

ciclopirox

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10
Q

allylamine, inhibits squalene epoxidase (a key enzyme for ergosterol)
highly active against dermatophytes but less active against yeasts

A

terbinafine

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11
Q

synthetic antifungal compound used for jock itch

against various dermatophyte & malessezia infections but not Candida

A

tolnaftate

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12
Q

bind fungal sterols (alter membrane permeability)

limited to topical treatment of cutaneous & mucosal candida infection

A

nystatin

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13
Q

binds to fungal sterols
limited to topical treatment of cutaneous candida infections
may cause temporary yellow staining of skin

A

amphotericin B

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14
Q

synthetic guanine analog works against herpes simplex types 1 & 2

A

Acyclovir

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15
Q

for anogenital pruritus

A

topical calcineurin inhibitors

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16
Q

useful for neuropathic itch

A

capsaicin

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17
Q

activate TRPV1 channels

induce lasting desensitization

A

capsaicin

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18
Q

Cox inhibitor
found in acne treatment & dandruff
treated areas are photosensitized

A

salicylic acid

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19
Q

alpha2-adrenergic agonist
topical gel for rosacea
vasoconstricts by stimulating post synaptic vascular alpha2 receptors

A

brimonidine

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20
Q

eye drops that are adrenergic receptor agonists

for rosacea

A

naphazoline, tetrahydrozoline, phenylephrine & oxymetazoline

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21
Q

organophosphate cholinesterase inhibitor
topical
for insects

A

malathion

22
Q

topical

bind insect Na+ channels block membrane repolarization

A

permethrin

23
Q

oral
bind glutamate-gated Cl- Channels in invertebraes
hyperpolarize n. & m. cells

A

ivermectin

24
Q

topical
only used after others fail
disrupts GABAergic transmission in insects

A

lindane

25
Q

topical retinoid
once daily at bedtime
local skin irritation, dryness and flaking skin sensitivity
careful with fish allergies

A

Tretinoin

26
Q

topical retinoid
2x daily
local skin irritation may bleach hair or clothing

A

benzyl peroxide

27
Q

topical retinoid
2x/1x daily (foam)
rare risk of pseudomembranous colitis

A

clindamycin

28
Q

dicarboxylic acid
white powder found in wheat, rye, barley, involved in plant defense resp to infection
kill acne bacteria & decreased keratin production
mild to moderate acne & treat post-inflammatory hyperpigmentation

A

Azelaic acid

29
Q

oral antibiotics
causes photosensitivity, GI distress
contraindicated in pregnancy & young children

A

Tetracycline & Doxycycline

30
Q

oral antibiotic
causes dizziness, drug-induced lupus, skin discoloration
contradicated in pregnancy & young children

A

Minocycline

31
Q

oral antibiotics

cause GI distress

A

erythromycin & azithromycin

32
Q

oral antibiotic

cause Steven-Johnson syndrome, toxic epidermal necrolysis

A

Trimethoprim-sulfamethoxazole

33
Q

K+ sparing diuretic
useful for adult women w/menstrual cycle-related breakouts
contraindicated in pregnancy menstrual irregularity

A

Spirolactone

34
Q 
psoriasis medication 
inhibits phosphodiesterase 4 (PDE4) 
increases cAMP 
decreases NO synthetase, TNF-a, IL-23 
increase IL-23
A

apremilast

35
Q

psoriasis medication
inhibits PDE4
approved as topical therapy for dermatitis

A

crisaborole

36
Q

subQ psoriasis medication
target IL-12 & IL-23
decreases NK cell activation, CD4 T-cell differentiation & activation, IL-8, TNFa and other cytokines
used for plaque psoriasis, psoriatic arthritis, Crohn’s disease

A

Ustekinumab

37
Q 
subQ psoriasis medication 
target IL-17A 
decrease production of other proinflammatory signaling molecules 
ankylosing spondylitis 
plaque psoriasis, psoriatic arthritis 
Toxicity: increase infection risk
A

secukinumab

38
Q

actinic keratosis treatment
used for genital warts
immune response modifier that stimulates local cytokine induction
activate toll receptors

A

imiquimod

39
Q

actinic keratosis treatment
derived from Euphorbia peplus sap
1) initial disruption of cell plasma membranes & mitochondria –> leading to cell necrosis
2) neutrophil-mediated Ab dependent cellular cytotoxicity that eliminates remaining tumor cells

A

ingenol mebutate

40
Q

an topical NSAID

important for skin carcinogenesis

A

diclofenac

41
Q

topical
inhibit thymidylate synthetase critical enzyme in DNA synthesis
prevent cell proliferation in dysplastic cells & cause cell death
cause inflammation & destruction

A

5-Fluorouracil

42
Q

treatment for advanced BCC

oral inhibitors hedgehog signaling

A

vismodegib and sonidegib

43
Q

treatment of melanoma

conventional chemo

A

dacarbazine

44
Q

treatment of melanoma
MAP kinase pathway
BRAF V600 inhibitor

A

vemurafenib

45
Q

oral alopecia treatment
vasodilates due to K+ channel opening
promote hair growth by elongating the duration of anagen (growth phase), shortening telogen (rest phase), & enlarging miniaturized follicles

A

minoxidil

46
Q 
oral alopecia treatment 
5a reductase inhibitor 
blocking DHT production 
can cause sexual dysfunction 
increase hair count
A

finasteride

47
Q

1st line of treatment for female hair loss

A

minoxidil

48
Q

2nd line of treatment for female hair loss

A

when minoxidil fails
anti-androgens:
spironolactone, finasteride, flutamide

49
Q

treatment of alopecia areata

A

intralesional or topical corticosteroids

50
Q

topical immunotherapy

used to cause dermatitis but somehow causes hair growth

A

diphenylcyclopropenone (DPCP)

SBL Exam 2 (2 decks)

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