Derm Pharm

Question 1

What is the degree of systemic absorption of topicals affected by? (5)

Answer 1

Skin thickness at site of application
Total area of application
Frequency of application
Blood flow at the site of application
Chemical and physical properties of the drug and the vehicle

Question 2

Drugs administered orally may undergo significant metabolism by:

Answer 2

Gut microbiome
Intestinal epithelia
Liver

Question 3

What are the 2 mechanisms of corticosteroids in derm?

Answer 3

• Suppression of eicosanoid synthesis by inhibition of phospholipase A2
• Suppression of immune cell activation and proliferation

Question 4

Topical corticosteroids in pregnancy?

Answer 4

FDA category C
- high potency is associated with lower birthweight
- cortisol is secreted in breastmilk
- use lowest potency

Question 5

When are high potency (groups 1-3) corticosteroids used?

What areas of the body should they NOT be used?

How long can they be used for maximum?

Answer 5

Used for severe inflammation (psoriasis, severe atopic derm, severe contact dermatitis, lichen sclerosis, bullous pemphigoid)

Do NOT use on face, groin, axilla, or under occlusive dressings

Use is 2 weeks MAX

Question 6

Most commonly used corticosteroid for intralesional injection:

Answer 6

Triamcinolone