Derm Agents

Question 1

Desrcibe the principles of absorption.

Answer 1

Absorption occur by diffusion through corneum, sweat ducts, and sebaceous glands.

Absorption is dependent on the concentration gradient, partition coefficient, and diffusion coefficient.

Question 2

What are three examples of drying applications and lubricating applications?

Answer 2

Drying - tinctures, lotions, and wet dressings

Lubricating - pastes, ointments, and creams

Question 3

How do you treat non-bullous impetigo?

Answer 3

mupirocin or retapamulin

Note: MOA = both inhibit protein synthesis

Question 4

What are the topical antibiotics for acne and their MOA?

Answer 4

Clindamycin - inhibits 50s subunit
Erythromycin - inhibits 50s subunit
Metronidazole - DNA damage

Question 5

What are other therapies for acne and their MOA?

Answer 5

Retinoids - augment production of sebum

Benzoyl peroxide - free oxygen radicals

Question 6

What are the therapies and MOA for fungal infections?

Answer 6

Azoles - inhibit ergosterol synthesis

Nystatin/Amphotericin B - increase membrane permeability by binding ergosterol

Question 7

What are therapies for HSV?

Answer 7

Acyclovir, panciclovir - block DNA synthesis

Imiquimod - elicits immune response through TNF-a, IL-1, IL-6, IL-8, and IFN-a

Question 8

What are topical retinoids for acne and the MOA?

Answer 8

Tretinoin, adapolene, tazarotene - increase expulsion of comedones

Question 9

What is the therapy for cystic acne?

Answer 9

Isotretinoin

Question 10

What are trichogenic agents?

Answer 10

Minoxidil and finasteride