Derm Flashcards

1
Q

What is the mechanism of terbinafine?

A

Inhibit squalene epoxidase

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2
Q

The reabsorption of what amino acid is defective in Hartnup disease?

A

Tryptophan

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3
Q

Which sweat gland is responsible for the odor of sweat?

A

Apocrine - initially odorless but can become malodorous secondary to bacterial decomposition on skin surface

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4
Q

Several white spots with an erythematous base on buccal mucosa suggest what viral infection?

A

These are Koplik spots - Measles (rubeola)

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5
Q

What follows Koplik spots?

A

Maculopapular rash within 1-2 days

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6
Q

Tryptophan is an essential amino acid and precursor for what 3 things?

A

Nicotinic acid, serotonin, melatonin

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7
Q

The clinical manifestations of Hartnup disease are primarily due to what?

A

B3 (Niacin) deficiency because niacin is synthesized from tryptophan

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8
Q

Hartnup disease is typically asymptomatic but can present like what?

A

Pellagra (niacin deficiency) - diarrhea, dementia, dermatitis

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9
Q

What is the key laboratory value in Hartnup disease?

A

Aminoaciduria restricted to the neutral amino acids

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