Derm Flashcards
What is the mechanism of terbinafine?
Inhibit squalene epoxidase
The reabsorption of what amino acid is defective in Hartnup disease?
Tryptophan
Which sweat gland is responsible for the odor of sweat?
Apocrine - initially odorless but can become malodorous secondary to bacterial decomposition on skin surface
Several white spots with an erythematous base on buccal mucosa suggest what viral infection?
These are Koplik spots - Measles (rubeola)
What follows Koplik spots?
Maculopapular rash within 1-2 days
Tryptophan is an essential amino acid and precursor for what 3 things?
Nicotinic acid, serotonin, melatonin
The clinical manifestations of Hartnup disease are primarily due to what?
B3 (Niacin) deficiency because niacin is synthesized from tryptophan
Hartnup disease is typically asymptomatic but can present like what?
Pellagra (niacin deficiency) - diarrhea, dementia, dermatitis
What is the key laboratory value in Hartnup disease?
Aminoaciduria restricted to the neutral amino acids