derm Flashcards
what are the four allergic patterns in cats?
- milliary dermatitis
- head/neck pruritis
- self-induced hypotrichosis/alopecia
- eosinophilic granuloma complex
DDX for miliary dermatitis
flea allergy dermatitis
food allergies
dermatophytosis
pemphigus
lymphoma
parasites
bacterial folliculitis
DDX for HNP
flea allergy dermatitis
food allergies
dermatophytosis
pemphigus
feline herpes dermatitis
mosquito bite derm
demodicosis
ear mites
SIAH DDX
endocrinopathy
bladder disease
eosinophilic granuloma complex lesions, causes
causes: FASS, ectoparasites, infection, idiopathic
eosinophilic plaque-> inner thigh, abdomen
eosinophilic granuloma-> caudal thigh, face, oral cavity
indolent ulcers-> associated w licking, lips
eosinophilic granuloma complex tx
plaque-> steroids, atopica, abx
granuloma-> steroids, atopica, immunotherapy
indolent ulcer-> abx
papule ddx
bacterial folliculitis
pustule ddx
pyoderma, pemphigus, demodicosis
crust ddx
secondary lesion- bacterial folliculitis, pemphigus
comedones ddx
dermatophytosis, demodicosis
epidermal collarette ddx
bacterial folliculitis, pyoderma
nasal planum disease ddx
discoid lupus erythematosus, mucocutaneous pyoderma,
canine atopic dermatitis distribution, pathogenesis
immune dysfunction: th2 cells, IL31, IL17, IL33
leads to impaired skin barrier function->increased allergen penetration
CAD allergens
dust mite, dust, molds, grass, weeds, dander
CAD C/S
pruritis
primary lesions-> erythema and papules
secondary lesions mostly-> excoriation, infection
ears, face, inguinal area, paws
CAD dx
- r/o other diseases that look similar-> ectoparasites, food trial, infection
- detailed analysis of hx, C/S (favrot’s criteria)
- demonstrate IgG-> intradermal testing, serum IgE
no pathognomonic test
CAD tx
apoquel MOA
janus kinase inhibtor-> inhibit cytokines involved in itching/CAD
fast-acting-> use for acute flares
cytopoint MOA
canine monoclonal Ab-> inactivates IL31
SQ injection, lasts 4-8wks
fast acting-> acute flares
atopica MOA
calcineurin inhibitor
slow acting (4-8wks)
has adverse effects-> gingival hyperplasia
steroids MOA
most effective for itching, allergic inflammation
pred
medrol-> dexamethasone most potent
used for acute rxns, ear stenosis, pododermatitis
topicals: soft steroids (hydrocortisone aceponate, mometasone), tacrolimus (cyclosporine)