Derm Flashcards
What are the four types of tissue?
Muscle
Nervous
Epithelial
Connective
What type of tissue generates physical force to make the body structure move and is arranged in bundles
Muscle tissue
What tissue has the poorest capacity for renewal and initiates/transmits nerve impulses that coordinate body activities and maintain homeostasis
Nervous tissue
What tissue has the best capacity for renewal
Epithelial
What tissue covers body surface, lines body cavities, hollow organs and ducts and forms glands
Epithelial tissue
What tissue protects and supports the body and its organs as well as provides immunity
Connective tissue
What provides contact or adhesion between neighboring cells or between a cell and extracellular matrix. They also maintain paracellular barrier of epithelia and control transport of materials or signals between cells (paracellular transport)
Cell junctions
What forms a barrier against water and antigens passing between individual epithelial cells
Tight junctions
What are cell-cell adhesions continuously assembled and disassembled so cells can respond changes in their micro environment
Adherens junction
What forms stable adhesive junctions between cells
Desmosomes
What allows various molecules and electrical signals to pass freely between cells
Gap junctions
What facilitates the stable adhesion of basal epithelial cells to the underlying basement membrane
Hemidesmosomes
What are the two categories of epithelial tissue
Covering and lining epithelium
Glandular epithelium
What is the most superficial layer of cells in epithelial tissue anatomy
Apical layer
What is the deepest layer of cells in epithelial tissue anatomy
Basal layer
What layer helps bind and support the epithelium and is located between the epithelium and underlying connective tissue layer
Basement membrane
What are two ways to classify epithelial tissue
Morphology - based on shape
Stratification - number of layers
What are thin, flat shaped to allow rapid passage of substances through them and can be keratinized or non-keratinized, “wet” or “dry” depending on their location in the body
Squamous epithelium
What type of epithelium frequently has microvilli at apical surface
Cuboidal epithelium
Where is cuboid epithelium found
Found in areas such as salivary glands and thyroid follicles
What type of epithelium protect underlying tissues and the apical surfaces may have cilia or microvilli
Columnar epithelium
What type of epithelium is useful for organs such as the urinary bladder when it is stretching to a larger size
Transitional epithelium
What is a single layer of cells that functions in a diffusion, osmosis, filtration, secretion and absorption
Simple epithelium
What is a simple epithelium that appears be stratified because the cell nuclei lie at different levels and not all cells reach the apical surface
Pseudostratified epithelium - single layer
- one specialized type of pseudo stratified cell are goblet cells, which secrete mucus and are an integral part of mucous membranes
Cells that do extend to the apical surface may contain what
Cilia
In mammals, what helps remove contaminates or move move particles by movin fluids over the cell layers. For example, the lining of the nasopharyngeal and Trachea are covered in it to remove mucus, bacteria and other debris from the lungs as well as the Fallopian tubes
Cilia
What increases the surface area of a cell by multiplying the area from 2 dimensions to 3 dimensions
Microvilli
What is a highly-insoluble fibrous protein with water proofing qualities and high friction resistance
Keratin
What are epithelial cells infused with keratin in the stratum basale of the epidermis called
Keratinocytes
Where is non-keratinized stratified epithelium found at
Found on wet/inferior surfaces exposed to considerable wear and tear such as the lining of the mouth, tongue, pharynx, esophagus and vagina
What type of tissue is bone, blood, lymph and cartilage
Connective
What are the three components of connective tissue
Resident cells -grapes in jello
Extracellular matrix (ECM) - jello
Protein fibers
What is the most common cells in connective tissue and is a major component of the reparative capacity of the tissue
Fibroblasts
What are fat cells specialized for cytoplasmic storage of lipid as neutral fats or less commonly for production of heat
Adipocytes
What is a component of loose connective tissue often located near small blood vessels in the skin and its function is localized release of compounds important to inflammatory response, innate immunity and tissue repair
Mast cells
What is the most abundant connective fiber that is very strong and resistant to shear forces
Collagen fibers
What are the connective tissue fibers
Collagen
Elastic
Reticular
What connective fiber provides strength and support in the walls of the small blood vessels. Stroma supporting framework of many soft organs; most notably the immune system, liver, endocrine glands, spleen and lymph nodes
Reticular fibers
What lines the entire GI, respiratory, reproductive and much of the urinary system
Mucous membranes
What is the general function of mucous membranes
Prevent cavities from drying out
What membrane lines a body cacvity that doesn’t open directly to exterior and covers organs that lie within the cavity
Serous membrane
What type of membrane lines the joints and secretes fluid to reduce friction, lubricate and nourish cartilage and removes microbes/debris from the joint cavity
Synovial joints
What is the surface layer of the skin that is not alive and comprised of epithelial tissue
Epidermis
What lies inferior to the epidermis and comprised of connective tissue. (Is alive)
Dermis
What is the top layer of the epidermis where cells consist mostly of keratin and where cells are shed and replaced from below
Stratum corneum
What layer of the epidermis is found only on the palms and soles of the hands and feet
Stratum lucidum
What layer of the epidermis loses cell organelles and nuclei as well as infusion of waterproofing lipids
Stratum granulosum
What layer of the epidermis is where cells begin to look flattened
Stratum spinosum
What is the bottom layer of the epidermis which is the stem cell layer and new cells arise here
Stratum basale
What layer of the skin contains the terminal ending of capillaries, lymph vessels and sensory neurons
Dermis
What is within the reticular region of the dermis
Roots do the hair
Sebasceous glands
Sweat glands
Receptors
Nails
Blood vessels
What is specialized cells of the epidermis and hair follicle and its primary function is to synthesis and transfer melanin to adjacent keratinocytes
Melanocytes
What cells touch and pressure are sensed by four types of mechanoreceptors in the skin and are expanded dendritic endings in epidermis of glabrous skin that responds to sustained pressure and touch
Merkel cells
What cells are typically found within the stratum spinosum. These monocyte-derived cells represent a large part of the skins adaptive immunity
Dendritic cells
What glands release secretions directly into the bloodstream
Endocrine glands
What gland releases secretions onto a epithelial surface via a duct
Exocrine glands - major role in derm
What is an exocrine gland in the skin that opens into a hair follicle and secretes an oily/waxy sebum
Sebaceous glands - sebum lubricates the hair in humans and mammals
What gland covers nearly the entire body surface and is especially dense on the palms, soles, forehead and upper limbs. It also empty’s directly onto the skins surface but not from the hair follicles
Sudoiferous - Eccrine glands
What gland is largely confined to the axillae, perineum and the concentrated hairy areas. it is attached to the hair follicle and empties onto the skin via the follicle opening
Apocrine glands
Which gland becomes active at puberty and have a hormonal pattern
Apocrine glands
What is the whitish crescent at base of nail plate
Lunula
What is the function of the nails
Protects the distal phalanges and surrounding soft tissue from injuries. It also enhances precise and delicate finger movements by exerting counter pressure on the puls of the fingers when grasping and manipulating objects
What color will the skin turn with a lack of oxygen
Blue
What color will the skin turn due to a buildup of bilirubin
Jaundice/ yellow
What color will the skin turn due to an engorgement of capillaries in the dermis with blood
Red
What color will the skin turn if someone is in shock or has anemia
Pale
What are the three main pigments that influence skin pigmentation
Melanin
Carotene
Hemoglobin
What is the primary determinant of skin color, hair color and eye color
Melanin
True or false, melanocyte numbers are the same in everyone
True - melanin is different in everyone
What will cause carotenemia
Excessive intake of lipid-soluble compounds in red, orange, yellow and green vegetables and fruit
What stimulates melanin production
UV light
What is a genetic condition characterized by little or no melanin pigment in the eyes, skin or hair
Albinism
What is an acquired depigmentation of the skin characterized by a loss of melanocytes
Vitiligo - autoimmune disease
What is the function of melanin
Protects against damaging effects of UV light
What are the functions of the skin
Temperature regulation
Protection
Sensation
Excrete and absorb
What activates the absorption of vitamin D
Exposure to UV radiation
- vitamin D is concerted to Calcitriol which aides in the absorption of calcium and phosphorus
What are the five signs of inflammation
Localized hyperthermia
Erythema
Localized edema
Pain
Loss of function
What is the inevitable physiological changes of the sin that occur with time and are influenced by genetic and hormonal factors
Intrinsic aging
What is the preventable structural and functional changes of the skin that occur with exposure
Extrinsic
What are some extrinsic factors that influence aging
Environmental
Lifestyle - tobacco, ETOH, illicit drugs
Social
Extensive cosmetic surgery
What is the most preventable extrinsic aging cause
UV radiation exposure
What happens during the epidermal aging
Decreased wound renewal capacity
Overall thinning of the epidermis
Decreased melanocytes - increased risk of skin cancer
Reduced responsiveness of langerhans cells - weakened cutaneous immunity
What happens during dermal aging
Reduced collagen fiber
Reduced elastin fibers
Decreased skin hydration and characteristic elderly xerosis
What are the two processes of tissue repair
Regeneration and replacement
What happens with regeneration tissue repair
Damaged tissue is completely restored to its pre-injury/normal state via new growth.
- Regeneration can happen continuously
What happens during the replacement phase
Severely damaged or non-regenerable tissues s repaired by the laying down connective tissue, resulting in SCARRING
When does the inflammation phase occur and what occurs
1-3 days post injury
- secretes mainly to clear bacteria and debris demotion he wound and prepares wound and environment for repair
When does the proliferation phase occur and what is its purpose
2-10 days post injury
- purpose is to construct granulation tissue to fill the defect caused by the wound
When does the healing phase occur and what happens in this phase
2- 3 weeks post injury
- early remodel phase
When does the healing- late remodel stage occur
Months to > 1 year
What is an example of healing by primary intention
Relies on the dermal edges that are close together and easily approximated
- sutures, staples and dermal adhesive
What is healing by secondary intention
Natural healing
- relies on formation of granulation tissue to fill the space between the wound opening or edges
What is an exaggerated IgE-mediated immune response triggering a histamine response
Atopy
What are the components of a skin, hair and nail exam
Inspection
Palpation