Derm

Question 1

Which of the following histologic patterns of inflammatory skin disease would be most likely associated with clinically detectable depigmentation:

Answer 1

Interface dermatitis

Question 2

Which of the following is/are true regarding panniculitis?

Answer 2

a) Refers to inflammation targeting the subcuticular adipose layer of the skin
b) The lesions are often nodular and drain to the surface
c) Is a condition in cats commonly caused by atypical mycobacterial organisms
d) In some animals, the condition can be a sterile, idiopathic condition

Question 3

Which of the following would be the least likely to lead to clinical and microscopic lesions of a nodular to diffuse dermatitis in a dog?

Answer 3

An ischemic dermatopathy

Question 4

Which of the following is a common mechanism of acantholysis?

Answer 4

Immune mediated destruction of proteins needed for cell to cell attachment

Question 5

Which of the following is an example of secondary lesion?

Answer 5

Scale

Question 6

Which of the following is an example of primary lesion?

Answer 6

Nodule

Question 7

Which of the following is a common pathogenesis of lesion formation in vasculitis?

Answer 7

Immune mediated Type III hypersensitivity reaction (antigen-antibody complex formation)

Question 8

Which of the following conditions can be a manifestation of underlying liver disease?

Answer 8

Superficial Necrolytic Dermatitis (SND)

Question 9

Vesicles and bullae can form by which of the following mechanism/s?

Answer 9

a. Thermal injury
b. Friction
c. Immune mediated destruction of cell to cell or cell to substrate proteins
d. Severe ballooning degeneration of keratinocytes

Question 10

The three most common causes of folliculitis in dogs are:

Answer 10

Follicular dwelling Demodex mites, Staphylococcal bacteria and dermatophytes

Question 11

The pemphigus complex of diseases was used in class as classic examples of what category of inflammatory skin disease?

Answer 11

Vesicular or pustular

Question 12

most common pathogenesis for lesion development in cases of an interface dermatitis is:

Answer 12

Damage to components of the basal cell layer of the epidermis or other component located at the dermal epidermal junction.

Question 13

most common pathogenesis for lesion development in cases of a perivascular dermatitis is:

Answer 13

A nonspecific hypersensitivity response

Question 14

Subcorneal pustules eventuate into:

Answer 14

Crusts

Question 15

Pemphigus Foliaceus:

Answer 15

a. The most common autoimmune skin disease seen in the dog.
b. Characterized clinically by pustules and crusts.
c. characterized by a salient histological finding of acantholytic keratinocytes within the epidermis and sometimes follicular walls.
d. A common differential for superficial pyoderma in the dog.

Question 16

Pautrier’s microabscesses:

Answer 16

are microscopic accumulations of neoplastic lymphocytes within the epidermis and are seen in cases of epitheliotropic lymphoma (aka- Mycosis Fungoides).

Question 17

Atrophic dermatoses that present with bilaterally symmetrical lesions are most often due to:

Answer 17

Hormonal imbalance

Question 18

example of focal atrophic dermatosis (dermatitis) caused by a vascular lesion that occurs most often in small breed dogs is:

Answer 18

Rabies vaccine associated lymphocytic vasculitis

Question 19

19. A condition used as an example of an interface dermatitis that features transepidermal apoptosis of keratinocytes and is represented clinically by target form or arciform, linear or serpiginous erosive lesions affecting the groin, axilla, the trunk or concave surface of the pinna is:

Answer 19

c. Erythema Multiforme (EM)

Question 20

What causes the formation of pustules in pemphigus foliaceus?

Answer 20

Loss of cohesion between keratinocytes due to the breakdown of cell to cell attachments

Question 21

Loss of cohesion between keratinocytes due to the breakdown of cell to cell attachments

Answer 21

Pustules

Question 22

Which of the following is most likely to precede the development of calcinosis cutis?

Answer 22

naturally occuring hyperadrenocorticism & iatrogenic hyperdrenocorticisim

Question 23

The biopsy should be performed so that the primary lesions are in the center of the biopsy sample.

Answer 23

True

Question 24

biopsy of completely ulcerated areas will prevent the diagnosis of which of the following?

Answer 24

emphigus foliaceus

b. Erythema multiforme
c. Superficial necrolytic dermatitis (hepatocutaneous syndrome)
d. Ichthyosis

Question 25

In multicentric vasculitis, where are the lesions most commonly located?

Answer 25

b. Tail tip
c. Pinnae
d. Footpads

Question 26

Shaving and surgical preparation of a skin biopsy site can prevent the diagnosis of which of the following?

Answer 26

a. Pemphigus foliaceus
b. Superficial dermatophytosis
c. Superficial pyoderma
d. Ichthyosis

Question 27

which of the following are true regarding chronic use of/abuse of topical corticosteroids?

Answer 27

a. It can lead to severe attenuation and loss of the dermal collagen fibers, resulting in loss of the dermal scaffolding support leading to a fragile dermis that is prone to injury.
b. Most commonly occurs in the glabrous skin areas (ventral abdomen and inguinal regions)
d. Will take months for the dermal architecture to repair and normalize following discontinuation of the product.

Question 28

When the goal is to identify a cause of alopecia & you can only biopsy 2 sites, which sites are most likely to provide the most information?

Answer 28

a. Normal haired skin

b. Area of complete alopecia