Depression Drugs By Class

Question 1

Selective Serotonin Reuptake Inhibitors (SSRI)

Answer 1

Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, Sertraline

Question 2

Serotonin- Norepinephrine Reuptake Inhibitors (SNRI)

Answer 2

Desvenlafaxine, Duloxetine, Venlafaxine

Question 3

Tricyclic Antidepressants (TCA)

Answer 3

Amitriptyline, Desipramine, Doxepin, Imipramine, Nortriptyline

Question 4

Norepinephrine and Dopamine Reuptake Inhibitor (NDRI)

Answer 4

Buproprion

Question 5

Mixed serotonergic effects

Answer 5

Nefazodone, Trazodone, Vilazodone

Question 6

Serotonin and alpha 2 adrenergic antagonist

Answer 6

Mirtazapine

Question 7

Monoamine Oxidase Inhibitors

Answer 7

Phenelzine, Selegline, Tranylcypromine

Question 8

This class is often chosen first due to it’s safety in overdose and improved tolerabilty.

Answer 8

SSRI

Question 9

Some studies suggest this class may be associated with higher rates of response and remission.

Answer 9

SNRI

Question 10

Common side effects of SSRIs

Answer 10

GI, sexual disfunction, headache and insomnia

Question 11

Common side effects of SNRIs

Answer 11

Insomnia, nausea, serotonin syndrome, sexual dysfunction

Question 12

Common side effects of TCAs

Answer 12

Anticholinergic (dry mouth, urinary retention, blurred vision, constipaiton, dizziness, memory impairment), delerium at higher doses, orthostatic hypotension, cardiac conduction delays, wt gain, sexual dysfunction

Question 13

Common side effects of MOAI’s

Answer 13

Postural hypotension, rare but serious: hypertensive crisis (give captopril).