Depression, Bipolar and Anxiety 36% Flashcards
Define GAD
chronic excessive worry >6 months + 3 or more of the following symptoms: (MISC RF)
- restlessness
- fatigue
- concentration problems
- irritability
- muscle tension
- sleep disturbance for 6 months or more
define panic disorder
anxiety disorder marked by unpredictable minutes-long episodes of intense dread in which a person experiences terror +
- accompanying chest pain
- choking
- or other frightening sensations.
>2 panic attacks w/ sx lasting >1 mo and woried about another attack
A group of anxiety disorders involving a pathological fear of a specific object or situation
Phobia
•Symptoms 10-15min prior to specific stress event
•6+ months of fear/anxiety about an object/situation
define panic attack
•Episode of intense fear or discomfort that develops abruptly; usually peaks within 10min, last <60min
Panic Disorder Criteria: + si/sx
Recurrent, unexpected panic attacks
2+ attacks x1 month and 1+ criteria sx
4/13 physical symptoms
Si/Sx
- persistent concern/worry of another attack
- worry of losing control during attack
- maladaptive behavior
define agorphobia
Tx?
Fear of going into places where you may not be able to escape
SSRI, CBT, or both
defien Social Phobia/ Anxiety
6+ months of intense fear of social situation or performance where you can be scrutinized
tx of phobic disorders
1st line
2nd line
triggers
agoraphobia
1st line: CBT/exposure therapy
2nd line: SSRI, Benzos
Specific, predictable trigger: Benzos
Agoraphobia: SSRI & CBT
tx of
panic attacks
panic disorder
acute panic attacks
Panic Attacks: Benzos (Lorazepam, Alprazolam)
Panic Disorder
- SSRI (Paroxetine, Sertraline, Fluoxetine)
- CBT
Acute Attacks: Benzos
Tx of GAD
SSRIs (Paroxetine, Escitalopram)
SNRI (Venlafaxine)
Benzos
Buspirone
•CBT x6-12 months
35-year-old female with a complaint of worry which she cannot control for the last year. She tells you that her symptoms daily consisting of sleep disturbances, difficulty concentrating, and irritability. She reports her symptoms started around age 17 but have worsened.
Dx??
Tx options
GAD: persistent and excessive worry pertaining to multiple events or domains that continues for 6 months or more
Treatment
- SSRIs: Paroxetine and escitalopram; SNRIs: Venlafaxine
- Buspirone is also effective; the starting dose is 5 mg PO bid or tid. However, buspirone can take at least 2 weeks before it begins to help
- BZD (short-term use), BBs
- Psychotherapy
26-year-old first-year PA student with a medical history significant for GERD comes to your office because of frequent episodes of palpitations. The palpitations are sudden in onset and are accompanied by sweating and a sense that she is going to “pass out.” The episodes typically last no more than 10 minutes, and although the patient feels as if she may pass out, she never has. The episodes first appeared when she started PA school and have increased in frequency to the point where she is afraid to attend lectures out of fear of having an “attack.”
Dx??
Tx??
Panic Disorder
Treatment
- SSRIs: Paroxetine, Sertraline, Fluoxetine
- Benzodiazepines: for acute attacks (watch for abuse)
- CBT (relaxation, desensitization, examining behavior consequences)
a lab technician calls to tell you that a 22-year-old man you have sent for a blood draw is very anxious. He says he is terrified of having his blood drawn and almost faints at the sight of the needle.
Phobia - Same as panic disorder – symptoms begin 10-15 minutes prior to stress event except in this case it is a specific stress event (i.e flying, blood, social situations, spiders etc. etc.)
Treatment
- Exposure therapy (first line), teach to relax and try to understand/overcome the fear
- SSRI + CBT
- Benzodiazepines (i.e prior to flying)
- Treat agoraphobia just as GAD with SSRIs and CBT
Name indication and MOA of Buspirone
Add on for anxiety
5HT-1a receptor agonist
•dopamine receptors
Hydroxyzine (Vistaril, Atarax) DDI & CI
DDI :
- Potassium
- MAOIs
- CNS depressants
CI
- Allergy
- 1st trimester prego
- *only use po route
CI for BZDs
- Pregnancy
- Allergy
- Myasthenia gravis
- Glaucoma
Tx optiosn for Bipolar
Lithium - (1st line)
Valproate (Depakote enteric coated) *increase GABA
Lamotrigine – *inhibit glutamate
Carbamazepine
side effect we are concerned for w/ Lithium
Ebstein anomaly is a rare heart defect in which the tricuspid valve — isn’t formed properly
Carbamazepine side effects
Nausea, rash, pruritis,
hyponatremia, fluid retention
leukopenia
when tx Bipolar what medications do you need LFTs?
Renal labs?
LFTS- valporate, carbamazepine, lamotrigine
Renal - Lithium
•SJS, TEN need to be watched for when starting what bipolar medications?
lamotrigine
carba
acute and long term effects of lithium
Acute: GI, tremor, thirst, polyuria, weight gain, loose stools
Long term: LITH-PA
- Leukocytosis
- insipidus (renal)
- tremor
- hypothyroidism
- parathyroid
- arrhythmia