Depression and Suicide Flashcards
which gender is twice as likely to be diagnosed with depression
women
women/men are more likely to seek help for depression and women/men are more likely to self-medicate with alcohol/substances
women more likely to get help
men more likely to self-medicate
which age group has the highest suicide rates and why
older men
older people use lethal means first
twins and depression rates
50% in monozygotic twins
20% in dizygotic twins
biochemical theories for depression
decreased level of serotonin
altered hormone regulation
increased cortisol
stress diathesis model
stressors and early life trauma may impact individual biological vulnerabilities
cognitive theory
negative thinking patterns
learned helplessness
older adults, women, impoverished
major depressive disorder diagnostic
5+ present in 2 weeks:
- depressed mood
- inability to feel pleasure
- insomnia/hypersomnia
- weight loss or gain
- psychomotor agitation or retardation
- loss of energy
- feelings of worthlessness/guilt
- impaired concentration
- suicidal ideation
MDD psychotic features X2
hallucinations
delusions
MDD catatonic features X3
non-responsive
psychomotor retardation
withdrawal
MDD peripartum onset
during the pergnancy and following delivery
may include psychotic features and risk to infant
seasonal affective disorder
most commonly occurs in fall or winter, remits in sprint
overeating
anergia
hypersomnia
Premenstrual dysphoric disorder (PMDD)
occurs in luteal phase
emotionally labile
anger or irritable
depressed mood
may also include lack of energy, overeating, sleep disturbances
baby blues
feeling depressed/anxious, crying for no reason
improvement within 1-2 weeks
postpartum depression
strong feelings of sadness, anxiety, despair
symptoms DO NOT subside
occurs within 1-3 weeks PP
may last for a year after birth
postpartum psychosis
extremely rare with rapid onset (within 3 days)
agitated, anxious, disorganized behavior
delusions are baby focused
QPR
question
persuade
refer
SADPERSON
male sex
age (<19 >45)
depression/hopelessness
previous suicidal attempts
excessive ethanol/drug use
rational thinking loss
separated/widowed/divorced
organized plan/attempt
no social support
stated future intent
suicide risk screening questions
do you want to hurt yourself?
do you have ideas of taking your own life?
have you made plans to take your own life?
Do you have the means and what are they?
have you tried to take your life before?
suicide risk screening points
0 = no risk
1-2 = moderate
3-5 = high risk
tylenol antidote
mucomyst
benzodiazepine antidote
flumazenil
opioid antidote
naloxone
1:1 suicide precautions
continual observation at arm’s length for actively suicidal
15 min precautions
observe every 15 minutes and document affect/behavior/location
nursing responsibilities for suicide precautions
can implement and then get orders but cannot discontinue without doctors orders
why are MAOI’s not first line
food and drug interactions
almost anything aged
almost any med
phenelzine class
MAOI
tranylcypromine class
MAOI
isocarboxazid class
MAOI
selegiline class and route
MAOI patch
why are TCA’s often not used
anticholinergic effects
anticholinergic effects saying
cant see
cant pee
cant spit
cant shit
suicidal ideation and TCA’s
do not use - potential for lethal overdose
when does full effect occur with TCA’s
4-8 weeks
amitriptyline class
TCA
doxepine class
TCA
imipramine calss
TCA
desipramine class
TCA
nortriptyline class
TCA
biggest risks in SSRI/SNRI use
serotonin syndrome or increased suicidal thoughts
fluoxetine class
SSRI
sertraline class
SSRI
paroxetine class
SSRI
citalopram class
SSRI
escitalopram
SSRI
fluvoxamine class
SSRI
vilazodone class
SSRI
venlafaxine class
SNRI
duloxetine class
SNRI
desvenlafaxine class
SNRI
bupropion
NDRI
trazodone
atypical antidepressant
mirtazapine class
NASSA
ECT
only when previous medication has failed
ECT remission rate
70-90% in depression
ECT and pregnancy
safe
when is ECT not effective X3
personality d/o
substance use d/o
situational depression
ECT course
6-12 treatments
2-3 times/weeks
how long does an ECT seizure alst
30-6- seconds
Vagus nerve stimulation
device left in chest wall with wire threaded around vagus nerve that delivers electrical impulses
what does VNS do
increase levels of neurotransmitters
DBS
experimental therapy for tx resistant depression
surgical implant of pacemaker device implanted in subclavicle region