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BBDA Spring (Exam 4) > Depression and Antidepressants > Flashcards

Depression and Antidepressants Flashcards

1
Q

Prozac

A

Fluoxetine (long half life, CYP450, jitters) am dosing

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2
Q

Zoloft

A

Sertraline (MINIMAL drug interactions, jitters) am doising

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3
Q

Paxil

A

Paroxetine (anti-cholinergic (dry mouth) and weight gain and sexual dysfunction, sedation)

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4
Q

Luvox

A

Fluvoxamine

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5
Q

Celexa

A

Citalopram (cardiac concern >40mg)

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6
Q

Lexapro

A

Escitalopram (less problematic than Citalopram)

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7
Q

Brintellix

A

Vortioxetine

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8
Q

Viibryd

A

Vilazodone

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9
Q

Clomipramine (causes seizures)

A

Anafranil (TCA and SSRI overlap)

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10
Q

TCA’s

A

Amitriptyline, Imipramine, Doxepin, Desipramine, Nortriptyline (More potent)

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11
Q

Effexor

A

Venlafaxine (GI and Sexual Dys. Adverse effects)

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12
Q

Pristiq

A

Desvenlafaxine (active metabolite of Effexor, significant renal elimination)

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13
Q

Cymbalta

A

Duloxetine (indicated for depression, neuropathy, pain) hepatotoxic with EtOH

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14
Q

Fetzima

A

Levomilnacipran

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15
Q

Trazodone

A

Oleptro (SR form)

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16
Q

Wellbutrin

A

Bupropion (Works on DA, use in substance abuse, minimal action at receptor, RISK of SEIZURE/tremor, MAY treat sexual dysfunction)

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17
Q

Remeron

A

Mirtazapine (decreased GI and sex. dys. effects and less sleep disturbance) increased drowsiness and appetite

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18
Q

Nardil

A

Phenelzine (MAOI)

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19
Q

Parnate

A

Tranylcypromine (MAOI)

20
Q

Marplan

A

Isocarboxazide (MAOI)

21
Q

EmSam

A

Selegeline Patch (MAOI)

22
Q

Unipolar Depressive Disorder

A

mood disorder, No mania or hypomania, Isolated episodes, chronic or recurring, debilitating, Social/Family and Employment impairments, SUICIDE RISK

23
Q

Bi-Polar Disorder

A

mood disorder, 1 or more episodes of mania or hypomania AND depressed (many times first), recurrent

24
Q

Mania

A

greater than 1 wk, elevated or expansive mood and IMPAIRMENT OF FUNCTION, grandiosity, excessive pleasure (like your on meth)

25
Q

Hypomania

A

less severe than mania, NOT psychotic, opposite of mania

26
Q

Depressive Disorder

A

Genetic Component and environmental role, Stress may precipitate those at risk, Women > Men, Onset is early to middle adulthood

27
Q

Diagnostic Criteria of Major Depressive Disorder

A

> 5 for a two week period, significant change in functioning, Either Depressed Mood or Loss of interest, then: change in weight, insomnia/hypersomnia, fatigue, indecisiveness, inappropriate guilt, psychomotor retardation, suicidal thoughts (not caused by underlying medical of pharmaceutical agent) SIG-E-CAPS

28
Q

Drug Induced Depression

A

Clonidine, Ethanol, Steroids, Estrogens, Interferons, Amnesteem

29
Q

Illness Induced Depression

A

Alzheimer’s, MS, Epilepsy, Parkinson’s, Addison’s, Hypothyroidism

30
Q

Depression Treatment

A

Pharmacotherapy, Psychotherapy (talk therapy), ECT (Electroconvulsiv Therapy), VNS, Trans-cranial Magnetic Stimulation, Light Therapy, Sleep Deprivation, Nutraceuticals

31
Q

Tricyclic Antidepressants

A

Not First Line, Prominently NE some 5HT reuptake inhibition

32
Q

TCA Adverse Effects

A

A1 Antagonists, M1 Antagonists, H1 Antagonists (increased appetite and weight gain), Cardiac Block, OVERDOSE TOXICITY

33
Q

TCA Dosing

A

Titrate Up, Dosing at bedtime, Drug Interactions (Dirty)

34
Q

SSRI Side Effects

A

Nausea/Anorexia, Insomnia, Sexual Dysfunction, Anxiety and Restlessness, Unwanted stimulation of 5HT-2 and 5HT3 receptors, Platelet Dysfunction, Water retention

35
Q

SSRI MOA

A

Prominent 5HT re-uptake blockade, NE too (but much less), Weight Neutral

36
Q

5HT-2 Stimulation

A

Nightmares, sleep disturbance, agitation, sexual dysfunct.

37
Q

5HT-3 Stimulation

A

GI Effects- N,V,D

38
Q

SNRI MOA

A

Serotonin/NE reuptake Inhibitor, work like TCA’s without TCA side effects

39
Q

Trazodone MOA

A

5HT reuptake inhibitor and 5HT2 antagonist, used as a hypnotic, can cause priapism

40
Q

Remeron MOA

A

A2-antagonist (increased 5HT and NE release) and 5HT2 and 5HT3 antagonis

41
Q

MAOI MOA

A

Release of NE and 5HT, 3-4th line, IRREVERSIBLE, tyramine diet restrictions, lots of drug-drug interactions

42
Q

Serotonin Syndrome

A

Myoclonus (involuntary jerking of muscle), Hyperreflexia, confusion, hypomania, potential Hyperthermia, seizures, dyspnea, chattering of the teeth.

43
Q

Serotonin Syndrome Frequency

A

Uncommon, seen with Triptans, Trazodone and others

44
Q

Serotonin Synd. Treatment

A

With drawl of serotonin agents, IV ativan, propranolol (5TH antagonist), cyproheptadine (5HT2 antagonist)

45
Q

Antidepressant withdrawal symptoms

A

opposite of serotonin syndrome, Flu-like symptoms (aches and pains), brain shocks and zaps, nausea

46
Q

Antidepressant Patient Education

A

Delayed onset of action, duration of therapy, withdrawal sx., use with alcohol, adverse effects

BBDA Spring (Exam 4) (3 decks)

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