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iTx ii > Depression > Flashcards

Depression Flashcards

1
Q

Tricyclic antidepressants (TCAs)
tertiary amines

A

clomipramine
amitriptyline
doxepin
trimipramine
imipramine

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2
Q

Tricyclic antidepressants (TCAs)
secondary amines

A

will have less AE - are the active metabolites of tertiary amines!
desipramine
nortriptyline
protriptyline

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3
Q

atypical antidepressants

A

Bupropion and Mirtazapine

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4
Q

Bupropion MOA

A
  • inhibits reuptake of NE and DA (no serotonergic activity)
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5
Q

Mirtazapine MOA

A
  • blocks presynaptic alpha2-adrenergic autoreceptors; blocks 5-HT2, 5-HT3
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6
Q

Mixed serotonergic Agents

A
  • Vilazodone
  • Trazodone
  • Vortioxetine
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7
Q

Vilazodone (Viibryd) MOA

A

inhibit 5-HT reuptake; partial agonist of 5-HT1a

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8
Q

Trazodone MOA

A

inhibit 5-HT reuptake; partial agonist of 5-HT2a

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9
Q

Vortioxetine (Trintellix) MOA

A

inhibit 5-HT reuptake
agonist at 5-HT1a
partial agonist at 5HT1b
5HT3 and 5HT7 antagonist (help w/ SSRI AE)

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iTx ii (4 decks)

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