DENTAL RADIOGRAPHY and RADIA TION BIOLOGY Flashcards
what is the unit of radiation? is it for particulate or EMR? does it give us information about energy or ionizing ability of radiation?
A. Roentgen (R)
• Measures the exposure (based on the amount of ionization of air molecules produced)
- ONLY for electromagnetic radiation (not particulate)
- NO information about energy or ionizing ability of radiation
what is the Gray (Gy)?
- Measures the amount of energy deposited in the irradiated matter
- Dependent on atomic number of absorber, and the energy of the radiation
what is the Sievert (Sv)?
• A measure of biological effect of the radiation
• e.g. “Equivalent dose” (Sv) = Dose (Gy) x radiation weighting factor
• e.g. “Effective dose” (Sv) = Equivalent dose (Gy) x tissue weighting
factor
what type of radiation has what amount of radiation weighting factor?
photons (e.g. xrays) - radiation weighting factor (W subscript R) 1 electrons - 1 neutrons (5 keV) - 5 high-energy protons - 5 alpha particles - 20
what does radiation weighting factor give to us?
…gives an estimate of the ionizing ability of a form of radiation (electromagnetic or particular)
For practical purposes, in diagnostic radiology using x rays…….
1R ≈ 0.01 Gy ≈ 0.01 Sv
it would be different if you were exposed to a particular level of gamma radiation, the ratio would change?
where does natural background radiation come from?
- Cosmic rays
- Earth’s crust
- Food
- Air - most obvious example is radon gas
- Building materials
- Human body
NATURAL BACKGROUND RADIATION - appox. 2.4 mSv (worldwide) TERRESTRIAL 2.0 mSv A. External 0.5 mSv (soil, building materials) e.g. wood < concrete < brick B. Radon gas 1.2 mSv C. Other internal (ingestion) 0.3 mSv COSMIC 0.4 mSv
how much dose does diagnostic imaging add in population dose worldwide?
Diagnostic imaging may add a population dose (average worldwide) of approximately 2.5 mSv per year
Dental radiology is estimated to contribute no more than
0.01 mSv 0.01/2.5 = 0.04%
what is whole body radiation?
Radiation exposing the entire body. Each unit mass of tissue in the body receives the same amount of radiation.
what is specific area radiation?
Radiation exposing a specific area of the body. Only a limited number of total body cells are exposed to ionizing radiation.
what are the two categories of effects of ionizing radiation on tissue?
- DIRECT
• direct effect on biological molecules - INDIRECT*
• free radical or H2O2 formation from radiolysis of H2O
what are biological molecules affected by ionizing radiation?
- Protein
- Lipids
- Carbohydrates
- NUCLEIC ACIDS*
• Damage to DNA primary cause of cell death, genetic mutations, carcinogenesis
what are potential effects at the cellular level?
- Death from changes to organelles
- Chromosome aberrations
- Reproductive death
the extent of possible damage to tissues is influenced by… (4 things)
Extent of possible damage is influenced by:
- Dose
- Volume of tissue irradiated
- Type of tissue
- Period of time in which dose is received
what is radiosensitivity of cells and tissues related to (two things)?
a. reproductive activity (mitotic rate) – highly radiosensitive cells will have high mitotic rates
b. degree of cellular differentiation – highly radiosensitive cells will be poorly differentiated (e.g. stem cells)
what are some highly radiosensitive cells (2)/organs(4)?
Stem cells (spermatogenic and erythroblastic) Basal cells of mucous membranes Lymphoid organs Bone marrow (not really an organ) Testes Intestines