Dendritic Cells

Question 1

Dendritic Cells

Answer 1

DCs form the bridge between innate and adpative immune responses
DCs process antigen that are presented to B an T cells activate adpative immune response
DC substes are circulating and tissue-resident

Question 2

Function of DCs

Answer 2

• Are the “sentinels” of the immune system and bridge the innate and adaptive immune responses
• Are the professional antigen-presenting cells (APCs) of the immune system
• Process and present antigen on MHC class I and II
• Activate T cells to mount responses against pathogens
• Prevent auto-immunity by modulating the activation of auto-reactive Tcells

Question 3

MHC- I vs. MHC-II

Answer 3

Question 4

T cells recognize antigen presented on MHC Class I and II

Answer 4

Question 5

Macrophages vs DCs

Answer 5

Macrophages
* Recruited to, and presist in tissues
* Produce cytokines (ex TGF-Beta) to resolve inflammation

DCs
* Patrol in tissues and in blood
* Traffic to LNs after antigen uptake
* Undergo activation and terminal differentiation
* Undergo apoptosis after activating T cells
* More efficient in antigen processing

Question 6

Where and how do dendritic cells develop?

Answer 6

Flt3L is produced by BM stromal cells, endothelial cells and activated T cells
DC precursors express Flt3

Question 7

Where do DCs reside?

Answer 7

• Intestine
• Lung
• Skin
• Nose
• Mouth
• Brain