Demyelinating Disease Flashcards
1
Q
A
Multiple sclerosis pattern of plaque deposition
Classically periventricular and perivenular
2
Q
In PML, affected oligodendrocytes will also express. . .
A
. . . TP53 and Ki67
Making them look malignant! They can even have a dysplasia-like atypia in addition to the classic JC morphology, shown here
SV40 clinches the diagnosis
3
Q
A
Amyloid angiopathy
Confirm with Congo red
4
Q
Perivenular dymelination DDx
A
MS
NMO
ADEM
5
Q
Acute vs chronic demyelinating lesions on histology
A
Acute lesions have much larger infiltrates of macrophages and lymphocytes
6
Q
The presence of eosinophils in the inflammatory infiltrate of a demyelinating lesion suggests. . .
A
NMO
