Dementia, Delirium, Depression - Exam 2 Flashcards

1
Q

What are 4 common themes when discussing NORMAL aging and cognitive function

A

Difficulty recalling names but REMEMBER them at a later time

NO functional impairment

SUBTLE deficits in memory function

learning remains intact

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2
Q

Cognitive function in older adults is considered a ______. What are the 3 different phases. What is the goal?

A

spectrum

early identification of reversible causes

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3
Q
A
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4
Q

** What are the cognitive impairment critical history points? slide 1

A
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5
Q

** What are the cognitive impairment critical history points? slide 2

A
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6
Q

When is the cognitive assessment not a reliable test? What should the general PE focus on?

A

when the pt has altered LOC or delirium

neuro exam
cardio exam
signs of abuse or neglect
screening for hearing/vision loss

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7
Q

What lab test should you order when thinking about a cognitive impairment? What is the imaging?

A

B12 and TSH

consider LP if concerned about hydrocephalus or CNS infection

brain CT/MRI w/o

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8
Q

______ is an intermediate state between normal cognition and dementia often seen in older adults. Give 3 characteristics

A

Mild cognitive impairment (MCI)

subjective memory loss

-Difficulty remembering names and appointments
- Difficulty solving complex problems
- Testing shows abnormal memory but no functional impairment

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9
Q

What should be your approach to mild cognitive impairment?

A

look for reversible causes: med SE, sleep, depression, vit B12 def, hypothyroid

modify vascular risk factors

nonpharm: regular exercise, cognitive training

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10
Q

** Is dementia reversible?

A

NO: Dementia is NOT reversible

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11
Q

What is dementia? What are 2 important highlighted things to remember?

A

A general TERM, not a specific disease, used to describe various conditions in which there are deficits in multiple areas of cognitive function resulting in impairment in daily functioning

**Gradually progressing course
**No disturbances in consciousness

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12
Q

What are the 4 different types of dementia? Which one is MC?

A

Alzheimer disease - most common
Vascular dementia
Lewy body dementia
Frontotemporal dementia

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13
Q

What is Alzheimer Disease? What 2 cerebral cortex lesions are associated with it?

A

AD is a neurodegenerative disorder of uncertain cause and pathogenesis; resulting in cognitive and behavioral impairment primarily in older adults.

Amyloid plaques
Neurofibrillary tangles

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14
Q

Under normal neuron circumstances, _____ inside of the _____, transport nutrients, organelles, and other messages from the cell body to the tip of the axon. ______ are the glue that hold the microtubules in place, allowing them to function appropriately

A

Microtubules

axon

Tau proteins

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15
Q

In a pt with AD, Neurofibrillary tangles occur when the ______ and adhere to each other instead of adhering to the microtubules. What happens as a result?

A

tau proteins breakdown

This results in inadequate transport from the cell body to the end of the axon, preventing neurons from communicating with one another appropriately

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16
Q

What are the risk factors for AD?

A
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17
Q

What is the classic triad presentation for AD? Do pts tend to have good insight into their condition?

A

Difficulty learning and recalling information

Visuospatial problems

Language impairment

pts often LACK insight into their symptoms

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18
Q

What is the order of disorientation that is commonly seen in AD?

A

time first
then place
then person (self)

in that order

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19
Q

When do you start to see behavioral changes in a pt with AD?

A

Depression, apathy, irritability early on in disease

Agitation and psychotic symptoms later in disease

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20
Q

AD is a _____ diagnosis. Must rule out _____. What will their brain MRI show?

A

clinical diagnosis

must rule out delirium

If performed may show diffuse cortical and/or cerebral atrophy ;greater degree of hippocampal atrophy

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21
Q

**What are the first line medications used to tx AD? What drug class?

A

donepezil (Aricept), galantamine (Razadyne), and rivastigmine (Exelon)

Acetylcholinesterase (Cholinesterase) inhibitors (AchEI)

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22
Q

______ MOA increase Ach at the neuronal synapses in the brain. What effect do they have in AD?

A

Acetylcholinesterase (Cholinesterase) inhibitors (AchEI): donepezil (Aricept), galantamine (Razadyne), and rivastigmine (Exelon)

slow progression of AD but there is NO evidence of slowing MCI to AD

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23
Q

_________ SE include nausea, anorexia, sleep disturbance and diarrhea. What are the dosing recommendations?

A

Acetylcholinesterase (Cholinesterase) inhibitors (AchEI)

donepezil
galantamine
rivastigmine

start low and go slow, titrate up every 2 months

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24
Q

______ MOA reduces the destruction of cholinergic neurons and may inhibit β-amyloid production, preserving memory. What drug class?

A

memantine

N-Methyl-D-Aspartate (NMDA) Receptor Antagonist

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25
What are the indication for memantine?
moderate-to-severe AD, unable to tolerate AchEI’s
26
What are lecanemab (Leqembi) and donanemab (Kisunla)? When are they used?
Amyloid-targeted therapy → recombinant monoclonal antibodies directed against amyloid beta -used to AD for those who are mild cognitive impairment or mild dementia MMSE ≥22; MoCA ≥17 -Amyloid positive patients as documented on PET scan / LP
27
What are some AD complications?
Worsening of comorbid conditions due to treatment adherence issues Increased risk of developing delirium in response to medical illness or surgery Advanced AD leads to poor nutritional intake, urinary incontinence, skin breakdown, and infections
28
When should you stop AD medications (AchEI and NMDA)?
once the pt is unable to express their needs
29
_______ a gradual or acute onset of cognitive dysfunction (not related to delirium) with clinical or radiographic evidence of cerebrovascular disease
vascular dementia
30
What is the clinical presentation of vascular dementia? How does memory impairment and depression compare to AD?
-memory impairment -Difficulty of timed activities and executive functions -Behavioral and psychological symptoms as in AD -depression -NO focal neurologic deficits Memory impairment is often LESS severe than AD but depression is MORE severe than in AD
31
What MRI finding is commonly seen with vascular dementia?
MRI may provide evidence of small infarcts (“white matter lesions”)
32
What is the tx for vascular dementia?
same as AD: Cholinesterase inhibitors, memantine and nonpharmacological therapy
33
What are Lewy bodies? Where else are they also seen?
Lewy bodies are deposits of Alpha-synuclein, a protein naturally found at the presynaptic terminals also seen in Parkinson's disease
34
What is the average age of onset for Dementia with Lewy Bodies? male or female? genetic component?
75 years: 50-80 male mostly sporadic-> very rare occurrence of family history
35
What are the core features of dementia with Lewy bodies?
Insidious in onset of fluctuating cognitive impairment (day-by-day) Visuospatial abilities, problem solving, and processing speed are MORE severe than AD early in course and memory is LESS affected spontaneous parkinsonism recurrent VISUAL hallucinations
36
What is the hallmark of DLB?
Spontaneous parkinsonism Bradykinesia, bilateral limb rigidity, flat affect (mask-like facies), postural instability and gait changes LESS likely to involve tremors or respond to levodopa
37
When comparing DLB to AD, _______ is often the first symptom that helps differ from AD. What is it?
Delusional misidentification mistaking the spouse, friend, or relative as an impostor
38
What are some suggestive features of DLB?
Rapid eye movement (REM) sleep disorder Sensitivity to antipsychotics including severe parkinsonism, impaired consciousness and neuroleptic malignant syndrome
39
What are some features of neuroleptic malignant syndrome?
a life-threatening idiosyncratic reaction to antipsychotic drugs characterized by fever, altered mental status, muscle rigidity, and autonomic dysfunction
40
What is the criteria called for the dx of DLB? how many do you need of each category?
McKeith criteria 2 core features OR 1 core and 1 supportive feature
41
**How does the brain MRI of DLB compare to AD?
Less atrophy of the medial temporal with greater atrophy in the basal ganglia structures and the dorsal midbrain
42
How does the brain MRI of DLB compared to Parkinson's dz?
More pronounced cortical atrophy than PD
43
What with SPECT (Single-photon emission computed tomography) show on a pt with DLB?
Reduction in dopamine uptake and perfusion
44
What is the management for DLB?
45
What are the atypical antipsychotics used in DLB?
olanzapine (Zyprexa) quetiapine (Seroquel) pimavanserin (Nuplazid) ziprasidone (Geodon) aripiprazole (Abilify) paliperidone (Invega) clozapine (Clozaril)
46
What is the objective data seen with DLB as the course progresses? What is the prognosis?
A decrease in the MMSE by 4-5 points per year mean survival is approximately 10 years
47
What are risk factors for higher mortality in DLB?
Older age, hallucinations, greater degrees of fluctuation, and neuroleptic sensitivity
48
_______ A group of clinical syndromes that results from degeneration of the frontal and temporal lobes of the brain. What age range?
Frontotemporal Dementia (FTD) typically presents earlier before the age of 65
49
_____ most common cause of early-onset dementia (age of onset <65 years old) Symptoms can begin in the ____
Frontotemporal Dementia (FTD) 40’s
50
What are the 3 clinical syndromes that are variations of Frontotemporal Dementia (FTD)? Which one is MC?
Behavioral variant (bvFTD)- MC Semantic primary progressive aphasia variant Primary progressive aphasia nonfluent/agrammatic variant
51
Which type of FTD? ________ Apathy, disinhibition, compulsivity, loss of empathy, and overeating, often but not always accompanied by deficits in executive control
Behavioral variant (bvFTD
52
Which type of FTD? ________ Lose the ability to decode word, object, person-specific, and emotion
Semantic primary progressive aphasia variant aka cannot interpret words
53
Which type of FTD? ________ Inability to produce words, often with prominent motor speech impairment
Primary progressive aphasia nonfluent/agrammatic variant aka cannot speak well
54
**What is the MRI hallmark finding of FTD?
Hallmark is a *focal atrophy of frontal, insular, and/or temporal cortex* Atrophy often begins *focally in one hemisphere* before spreading to anatomically interconnected cortical and subcortical regions
55
**MRI findings for different types of FTD. ________ Anterior temporal degeneration
semantic variant PPA
56
**MRI findings for different types of FTD. ________ Medial and orbital frontal and anterior insula degeneration
Behavioral variant FTD
57
**MRI findings for different types of FTD. ________ Dominant hemisphere lateral frontal and precentral gyrus atrophy
Nonfluent/agrammatic PPA
58
What is the management for FTD? What is the prognosis?
from onset of symptoms approx. 8-10 years. shorter for pts with behavioral variant FTD
59
Look at this chart for comparison of the common types of dementias
60
______ an accumulation of CSF that causes enlargement of the ventricles in the brain and compression of surrounding structures. What are the 2 different versions?
Normal Pressure Hydrocephalus (NPH) idiopathic NPH secondary NPH
61
_______ underlying condition leads to inflammation and fibrosis at the base of the brain and/or the arachnoid granulations, impairing CSF resorption
secondary NPH
62
What are the 3 characteristics of NPH? What happens after intervention?
normal pressure hydropcephalus (NPH) by abnormal gait, urinary incontinence, and dementia gait often improves but dementia and incontinence do NOT
63
What is the imaging of choice for NPH? What is the hallmark finding?
MRI/CT- MRI is preferred Hallmark is ventriculomegaly in the absence of, or out of proportion to, sulcal enlargement
64
What are the LP results in a pt with NPH?
Normal opening pressure pt's gait improves when 30-50 cc of fluids are removed
65
What is a good prognostic sign for a shunt in pt with NPH?
Improvement in gait is a good prognostic sign for ventricular shunt placement once 30-50 cc of CSF is removed during LP
66
Where is the MC place to shunt the excessive CSF in NPH? Name one additional option
MC shunting into the abdomen (ventriculoperitoneal) Less common into the heart (ventriculoatrial)
67
**What is the big thing to note about delirium?
**delirium is reversible**
68
_______ A disorder characterized by an acute change in attention and cognition due to an underlying illness, stressor or precipitant exposure
delirium
69
What is the greatest predisposing risk factor for delirium?
preexisting cognitive impairment specifically dementia
70
What is the clinical presentation of delirium?
acute onset (hours to days) of cognitive impairment and functional decline reduced ability to focus, memory deficits, disorientation
71
What are some nonpharm strategies for a pt with delirium?
72
When are pharm strategies used in delirium management? What is the goal?
severely agitated individuals who threaten medically necessary care and pose a safety hazard to use the lowest dose possible for the shortest period of time with the goal of an awake and manageable pt NOT a sedated one
73
**What is the BZD of choice for delirium? Why?
lorazepam (ativan) because it has a shorter 1/2 life
74
**delirium is a ______ condition once the underlying cause is identified. What does it increase your risk of later on down the road?
fully reversible condition more likely to be diagnosed with dementia at a later date
75
What are the risk factors for delirium? What are ways to prevent them?
76