Dementia and the mental well being Flashcards

1
Q

is Dementia an actual disease??

A

Dementia is NOT a disease itself, but a group of symptoms that can accompany certain diseases or conditions.
It’s a broad term that can be defined as a condition involving:
impairments in thinking,
remembering, and reasoning,
which affect a person’s function and safety

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2
Q

so how would you define it??

A

Dementia is neither a behavioral, a cognitive nor a functional disorder
Dementia is a chronic, progressive brain illness that affect memory, cognition, and daily function. It is often accompanied by psychiatric symptoms
Family and caregivers are critical
Clinicians cannot rely solely on the patient for reports of symptoms

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3
Q

age associated impairment vs. mild congnitive impairment

A
Age Associated Memory Impairment
Subjective memory complaints
Poor memory test performance compared to young adults
Normal general cognitive function
No difficulty with ADL
Mild cognitive Impairment
Subjective memory complaints
Poor memory test performance compared to age- matched peers
Normal general cognitive function
No difficulty with ADL
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4
Q

MCI vs. Dementia

A

Memory complaints
Abnormal memory of age/ education
Normal general cognitive function

Still normal function - ADL
Memory complaints
Abnormal memory for age/ education
Abnormal cognitive function in at least one more domain:
Language
Abstract thinking
Perception
Judgment
Personality change
Impaired function - ADL
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5
Q

Neurocognitve disorder! How would you define this??

A

Decline in one or more cognitive domains based on: (apraxia, aphasia, memory, executive functioning)
Observation
AND
Objective assessment
Deficits interfere with ADL and IADL
Not due to Delirium, Major Depressive Disorder or Schizophrenia

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6
Q

causes of dementia

A
Neurocognitive disorder: Alzheimer’s disease, Dementia with Lewy bodies, Parkinson disease dementia, Frontotemporal dementia, Huntington’ disease
Vascular: Multi-infarct
Inflammatory : MS
Cancers: primary, metastatic
Other physical: hydrocephalus, trauma
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7
Q

what is the primary disease that causes dementia???

A
Alzheimer’s disease : 60-85%
Dementia with Lewy body: 15-30%
Vascular Dementia: 5-20%
Frontotemporal Dementia: 5-10%
Others: 10-15%
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8
Q

what is the third leading cause of death in the elderly and what is retrogenesis???

A

6th Leading cause of death – (3rd for the elderly)

Retrogenesis – back to birth—unravels the brain in reverse order (reverse developmental theory) Barry Reisberg, MD

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9
Q

1 in 3 people over age of what have dementia??

A

1 in 3 people over the age of 85 have AD
4% of people under the age of 65 have AD
The rate of AD doubles every 5 yrs after age 65 reaching 30-50% in those 85 and older
10,000 baby boomers will be turning 65 every day for the next 15 yrs (77million)
The G-8 and the US congress have made finding treatment by 2025 a top priority

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10
Q

Who is the most likely race to get alzheimers

A

African Americans : are about 2x more likely to have Alzheimer’s and other dementias than Whites
Hispanics are about 1 ½ times more likely to have AD and other dementias than whites

There are NO Known genetic factors that can explain the greater prevalence of AD in African American and Hispanics (obesity , smoking..)

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11
Q

warning signs of dementia

A

Challenges in planning or solving problems
Difficulty completing familiar tasks at home, work, leisure
Confusion with time or place
Trouble understanding images, spatial relationships
New problems with words in speaking or writing
Misplacing things and losing the ability to retrace steps
Decrease or poor judgment, changes in mood
Withdrawal from work or social activities

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12
Q

Signs of dementia

A

Memory: difficulty recalling names, phone numbers, misplacing objects, remote recall mildly impaired
Visuospatial: topographic disorientation, poor complex constructions, becoming disoriented
Language: mild word find difficulties, difficulty communicating ideas
Personality: indifference, occasional irritability, anxiety, suspiciousness and depression, lose insight
Psychiatric: sadness or delusions in some patients
Motor: normal
CT/MRI: essentially normal

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13
Q

severe AD how would you describe it??

A

8-12 year Duration
Intellectual functions: inability to recall children’s or spouse’s name, disorientation to place and eventually person
Function: unable to function independently
Personality: socially inappropriate behavior, flat or restricted affect, agitated
Motor system: limb rigidity and flexion postureSphincter control: urinary and fecal incontinence
EEG: diffusely slow
CT/MRI: ventricular dilatation and sulcal widening

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14
Q

last stages of sevre AD

A
Seizures
Urinary and fecal incontinence
Loss of ability to walk
Contractures
Bedridden
Mute
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15
Q

stage 1 and 2 of dementia describe them!!

A

Stage 1: No disability noted
Stage 2: (very mild cognitive decline)
Clinically labeled the forgetfulness phase.
C/O forgetting where one has placed familiar objects
Forgetting names of persons one formally knew well.
No objective evidence of memory deficit on clinical interview
No objective deficits in employment or social situation

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16
Q

stage 3 of Dementia

A

Stage 3:(mild cognitive decline)
Clinically labeled as early confusional
Earliest clear cut deficits noted
Word and name finding deficits become evident
Ability to retain material from a reading passage in a book is lost
Objects of value lost by patient
Patients begin to deny there is a problem
Patient gets lost when traveling to unfamiliar places
Mild to moderate anxiety accompanies symptoms
Objective evidence of memory deficit obtained only w/ intensive interview

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17
Q

stage 4 dementia

A

Known clinically as late confusional phase
Decreased knowledge of current and recent events
Decreased ability to handle finance and travel
May be able to travel to familiar places, recognize familiar persons and be oriented to time and person
Can no longer perform complex tasks
Denial is dominant defense mechanism
Withdraws from challenging situations
Flattening of affect noted

18
Q

stage 5

A

Difficulty choosing clothing to wear
Disorientation to time and place frequently exhibited
Often knows his/her name and those of spouse and children
Difficulty recalling major relevant aspects of one’s current life
Needs assistance in order to survive

19
Q

stage 6

A

Clinically labeled as middle dementia
Unaware of all recent experiences and events in ones life
Entirely dependent on others for survival
Occasionally forgets name of spouse
Unaware of surroundings
Require assistance with adl’s
Can usually recall ones own name
Pronounced personality changes can occur, including agitation, violent behavior, anxiety

20
Q

stage 7

A
Clinically described as late dementia
All verbal abilities and psychomotor skills are lost
Requires assistance for adl’s
Incontinent of urine
Patient can no longer command the body
Clinically described as late dementia
All verbal abilities and psychomotor skills are lost
Requires assistance for adl’s
Incontinent of urine
Patient can no longer command the body
21
Q

pathogenesis of AD

A

Amyloid plagues:
Neurofibrillary tangles
Chololinergic hypothesis: Genetic factors
Chronic inflammation
Neurotransmitter deficits: Acetylcholine, Glutamate-induced calcium dysregulation
Oxidative stress (toxins, free radicals)
Amyloid rich plaques: toxic, disrupts potassium and calcium channels

Neurofibrillary tangles: tangles insoluable

Cholinergic hypothesis: Acetylcholine (Ach) is los

22
Q

drugs believed to help with um mild to moderate AD

A

Acetylcholinersterase inhibitors: act by inhibiting actetylcholinersterase activity; resulting in an increase in Ach in the synaptic cleft
Drugs: Tacrine, Aricepts, Exellon, Galantamine
Only in Mild – Mod AD

23
Q

Glutamate believed to cause neuronal toxicity and drug menantine does what??

A

Glutamate: excessive and erratic glutamate stimulation cause neuronal toxicity and impair learning: Theory: normalize glutamatergic neuro-transmission to maintain or improve cognition
Drug Memantine: less decline in cognition, function, reduction in caregiver time

24
Q

possible good factors for not getting AD

A

Dementia free family history
High education or SES
Dietary vitamin E
Apolipoprotein e2 genotype

25
Q

some tests to use to test Dementia

A
MMSE
Clock drawing test
The mini cog
The SLUM
MOCA
Trail making test (including oral)
Global Deterioration Scale of Assessment (correlates to the Reisberg scale)
26
Q

What does the Montreal occupational assessment test for??

A
Sections : 
Executive functioning/ visuospatial
Naming
Memory
Attention 
Language
Abstraction
Delayed recall
Orientation
Two scoring scales based on level of education
Score out of 30 (> 26 is normal)
27
Q

What is the average time it takes someone to complete the trail maps?? does it mean that the people are impaired

A

Average Deficient Rule of Thumb
Trail A 29 seconds > 78 seconds Most in 90 seconds
Trail B 75 seconds > 273 seconds Most in 3 minutes

28
Q

What is the purpose of the trail making map

A

Test of “executive function”- higher cognitive issues: planning, initiating, sequencing, monitoring, stopping complex behavior, abstract thinking

Useful with visual and motor impairment

29
Q

BERG, tinetti, Gait assessment what is the best for the elderly???

A

Berg Balance Measure: Balance Skills in Elderly
•Tinetti Assessment Tool: Balance and Gait Skills
•Gait Assessment Rating Scale (GARS)
•ROM: Range of Motion and tone assessment

30
Q

commonly used drugs for Severe AD

A
Mild, Moderate AD
Aricept
Exelon
Moderate , Severe AD
Aricept
Exelon
Memantine/ Namenda

Dementia of Parkinson’s Disease
Exelon

31
Q

What is Vascular dementia????

A

3rd leading cause of dementia
Specific types: multi-infarct dementia; hemorrhagic dementia
Criteria: dementia, signs of cerebro-vascular disease in history, brain images with lesion in area important for higher cortical function
Clinical features: gait disturbance, urinary incontinence, apathy, emotional incontinence
Risk factor : age, HTN, DM, A-fib, CAD

32
Q

signs of vascular dementia

A
Apathy
Lack of motivation
Lack of will to do anything (abulia)
Looks like depression
Variable deficits depends on stroke location
Dysarthia
33
Q

Dementia with Lewey Bodies

A

Progressive form of dementia
Second most common
20% of all dementia
Age varies from mid to older adult
Neurodegenerative disorder characterized by abnormal structures found in brainstem and hippocampus.
Abnormal structures: collections of abnormal proteins, damage nerve cells

34
Q

Demetia with Lewy bodies describe what happens!!!

A

Lewy bodies – faulty production of protein that builds up within the nerve cells
Frederich Lewy, colleague of Alois Alzheimer (1912)
Symptoms:
Fluctuating cognitive impairment with episodic delirium
Prominent psychiatric symptoms, visual hallucinations much more common than (AD, or Parkisons dementia ) apathy, anxiety, depress
Gait disturbances, bradykinesia of extremities or face or rigidity of limbs or resting tremors this is worst type

35
Q

dementia frontal or temporal lobe

A

5 -10% of dementias
Early age of onset (late 50s to early 60s)
About a decade earlier than AD
Very often familial (40-60%)
In up to 50% of these familial cases; mutation in the tau (taw)gene
Behavioral FTD

Language FTD
Primary Progressive Aphasia
Semantic Dementia

Apathy
Dis-inhibition, social impropriety, impulsivity
Excessive eating of food
Stereotyped, rigid, compulsive behaviors, echolalia (repetition of phrases)
Neglect of personal hygiene
Memory deficits
Decrease planning, organization skills
Primary Progressive Aphasia
Difficulty in speech expression
Searching for words
Non fluent
Normal comprehension
Semantic Dementia
Loss of semantics (meaning) of words
Difficulty in speech comprehension
Early age of onset 
Very often familial
Behavioral FTD: apathy, social withdrawal, hyper-sexuality, change in previous preferences, neglect in hygiene
Language FTD: difficulty in speech expression, non-fluent, normal comprehension
Rate of progression similar to AD
36
Q

alcoholic dementia

A
Confusion may be the most obvious symptom of dementia, but this confusion is also accompanied by obvious memory problems
Those suffering from dementia may remember in great detail events that happened years ago, but are not able to recall events that took place in the past few minutes
At the same time they can seem to be in complete possession of their faculties:
Able to reason well
Drawing correct deductions
Makes witty remarks
Playing games that require mental skills (such as chess or cards)
Personality changes
Frustration, Anger, and Irritability
Emotional Lability, Unstable moods
Paranoia, Suspicion, and Jealousy
Insensitivity to Others
Flat Emotional Responses
Loss of Inhibitions
Fear of being alone
Loss of problem- solving skills
Inability to do Familiar Tasks
Inability to Make Connections
Inability to Make Decisions
Inability to Initiate or Complete a Project
Personality changes
Confabulation
Loss of problem solving skills
37
Q

validation therapy

A

Validation Therapy: based on responding to the feelings a patient is trying to communicate and not the actual words
For e.g. by asking for a deceased spouse a person may be expressing loneliness or sadness. Instead of reminding the person his spouse is dead, assure him that he is cared for and valued where he is

38
Q

create moments of joy???

A

Live their reality: help them to hold on to their LTM
Living their truth: your body language and tone of voice need to be genuine
If you hesitate or look confused, the person will sense this and may be suspicious

39
Q

How to act when its hard to understand the patient

A
Listen actively
Focus on a word or a phrase
Respond to the emotional tone
Stay calm
Ask family members about possible meaning
Respond as though you understand
40
Q

common reasons of difficult behavior

A

Medications
Physical problems
Environment
Tasks too complicated

41
Q

When a person with AD becomes confused due to these characteristics

A

Over stimulation
Excessive commands
Rapid questioning
A sense of failure