Dementia 3

Question 1

What is the Prevalence for Major Neurocognitive Disorder for all individual above the age of 65?

How does the prevalence change over time?

Answer 1

10%

Prevalence rate double every 5 years after age 65…starting at around 2% at 65….by 90-94 years old 50% prevalence.

Question 2

What are the 6 Neurocognitive domains?

Answer 2

1. Complex attention
2. Executive functioning
3. Learning and memory
4. Perceptual-motor function
5. Language
6. Social Cognition

Question 3

Alpha-Synuclein is implicated in the pathogenesis of what Major Neurocognitive Disorders?

Answer 3

Lewi Body Dementia
Parkinson’s Disease
Multisystems Atrophy

Question 4

What are the top 3 most common Major Neurocognitive Disorders? What is the % they represent?

Answer 4

1. Alzheimers (66%)
2. Lewy Body (20%)
3. Cerebrovascular/multiinfarct dementia (15)

Question 5

Which Major Neurocognitive Disorder is associated with Amyloid plaques (Amyloidopathy)?

Answer 5

Alzheimers

Question 6

Which Major Neurocognitive Disorder is associated with Tau protein (Tauopathies)?

Answer 6

• Alzheimers (both Tau and Amyloid)
• Major NCD due to Down’s syndrome
• Frontotemporal Dementia
• Progressive supranuclear palsy
• FTDP -17 (frontotemporal dementia with parkinsonism associated with chromosome 17)

Question 7

Cortical Dementias are characterized y loss of cognitive function in the 4 As…what are they?

Answer 7

1. Amnesia
2. Aphasia
3. Agnosia
4. Apraxia

Question 8

The MMSE does a poor job in testing what cognitive domain?

Answer 8

Executive functioning

Question 9

Which labs are required for work up of Major NCD?

Answer 9

1. CBC/CMP (renal function, electrolytes, LFT)
2. Glucose
3. TSH
4. B12
5. Urinalysis
6. Neuroimaging (CT or MRI)

Question 10

Which labs are only ordered IF indicated for workup of Major NCD?

Answer 10

1. HIV/Syphilis
2. Utox
3. Functional Neuroimaging (PET/SPECT)
4. EEG
5. LP
6. DNA analysis