Dementia

Question 1

MC form of dementia in adults

Answer 1

Alzheimer Dz

Question 2

Which congitive domain is 1st affected in dementia?

Answer 2

Learning & MEMORY

Question 3

Normally, when cells get old, our body cleaves Amyloid protein by Alpha and Gamma Secretase.
In Alzheimers Dementia, Alpha secretase is replaced by _____ secretase -> insoluble sticky ____-amyloid plaques

same word for both

Answer 3

BETA

cytokines are released d/t plaques -> cell death, brain atrophy/shrinkage

Question 4

Which Meds can put you at higher risk for Alzheimers?

Answer 4

• Anticholinergics
• PPIs
• Antihistamines
• Opiods

Question 5

which 3 Social/Environmental factors will increase your risk for Alzheimers?

Answer 5

• Smoking
• Air pollution
• Pesticides (DDE)

Question 6

Memory complaints d/t Alzheimers may occur up to ___yrs prior to a Dx

Answer 6

16

Question 7

Which form of dementia is most likely to occur in someone with down syndrome?

Answer 7

Alzheizmers

ss will occur 10-20yrs younger than general population

Question 8

Tx for Alzheimers

Answer 8

• Cholinesterase Inhibitors (Donepezil, Rivastigmine, Galantamine)
• NMDA Blockers -> Memantine (Namenda)
• Aducanumab (Aduhelm)

Question 9

Which form of dementia is “early onset dementia” where there is an obvious change in behavior, personality, and language

Answer 9

Frontotemporal dementia (FTD)

Question 10

Frontotemporal Dementia is Autosomal _____

Answer 10

Dominant

Question 11

Which form of dementia will have a (+) Babinski reflex?

Answer 11

Frontotemporal Dementia

Question 12

Tx for Frontotemporal Dementia

Answer 12

• Safety & driving
• Exercise & Mobility
• SSRIs
• Antipsychotics (LAST RESORT FOR BEHAVIORAL PROBS)

Question 13

2nd MCC of Dementia

Answer 13

Vascular Dementia

Question 14

In order to R/O Delirium, you need order which labs?

Normal labs = r/o delirium

Answer 14

• B12
• CBC
• TSH
• RPR/HIV (if risk)
• UA

Question 15

A Hachinski Ischemic Score of ___+ = Vacular ET very likely

Answer 15

7

Question 16

Cholinesterase inhibitors only work for vascular dementia if…..

Answer 16

MIXED Dementia is very likely (VD + AD)

will NOT help if purely vascular (VD)