Deja Review - Biochemistry I

Question 1

ELISA

Answer 1

determine presence of Ab or Ag in test sample

Question 2

cell concentrations of lytes

Answer 2

K - intracellular

Na and Ca - extracellular

Question 3

crumpled tissue paper cells

Answer 3

gaucher disease

Question 4

vit A defciency

Answer 4

ocular abnormal
night blindness
keratomalacia - soft cornea

squamous metaplasia of resp tract

Question 5

vit A in eye

Answer 5

11-cis to all trans - with light

vit A - regenerate rod cell rhodopsin - 11-cis

Question 6

beta-carotene

Answer 6

precursor to vit A

Question 7

deficient vit E

Answer 7

erythrocyte fragile - hemolysis

Question 8

vit D from sun

Answer 8

cholecalciferol - D3

Question 9

vit D from milk

Answer 9

ergocalciferol - D2

Question 10

confabulation

Answer 10

exaggerated lying story

with wernicke-korsakoff

hemorrhagic lesion - maxillary bodies and paramedian gray mater

Question 11

dry and wet beriberi

Answer 11

thiamine - B1 deficiency

dry - dilated cardiomyopathy
wet - polyneuropathy

Question 12

pathways with B1 cofactor

Answer 12

oxidative carboxylation a-ketoacids

transketolase in HMP shunt

Question 13

measure of B1 deficiency

Answer 13

transketolase activity in RBCs

Question 14

riboflavin

Answer 14

vit B2

FAD and FMN

Question 15

niacin

Answer 15

vit B3

NAD and NADP

reduction and oxidation reactions

Question 16

hartnup disease

Answer 16

get B3 deficiency

inadequate tryptophan absorption in gut and renal tubules

Question 17

B3 deficiency in carcinoid

Answer 17

because tryptophan being used to synthesize serotonin instead of niacin

Question 18

function of B5

Answer 18

panthenoic acid - CoA

for fatty acid synthesis

Question 19

sups with isoniazid

Answer 19

need B6

Question 20

pathways use B6

Answer 20

GABA production
transaminoation cofactor
decarboxylation cofactor

Question 21

cobalamin

Answer 21

B12

Question 22

B12 deficient in japanese immigratn

Answer 22

diphyllobothrium datum

-fish tapeworm

Question 23

test localize B12 deficiency cause

Answer 23

shilling test

Question 24

require folic acid pathways

Answer 24

synthesis of nitrogenous bases - purines and thymine

Question 25

biotin

Answer 25

vit B7

Question 26

pathways used B12

Answer 26

homocysteine methylation to methionine

Question 27

menke disease

Answer 27

copper deficiency -X-linked disease kinky haur and mental retardation

Question 28

tx cyanide poisoning

Answer 28

thiosulfate | hydroxocobalamin

Question 29

CCl4 exposure

Answer 29

centrilobular necrosis and fatty change of liver

Question 30

tx ethylene glycol toxicity

Answer 30

fomepizole | ethano

Question 31

lead toxicity anemia

Answer 31

hypochromic microcytic decreases heme synthesis

Question 32

lead inhibits what enzymes

Answer 32

d-ALA dehydratase | ferrochelatase

Question 33

fanconi syndrome

Answer 33

impaired renal absorption of AA, glucose, and P association with lead toxicity

Question 34

tx lead poisoning

Answer 34

succimer penicillamine EDTA dimercaprol

Question 35

antidote B-block

Answer 35

glucagon

Question 36

antidote TCA

Answer 36

sodium bicarb

Question 37

antidote quinidine

Answer 37

sodium bicarb

Question 38

gingival hyperplasia, hirsutism, folate deficiency

Answer 38

phenytoin

Question 39

severe flushing with lipid agent

Answer 39

niacin

Question 40

lupus like syndrome drugs

Answer 40

hydralazine INH procainamide phenytoin

Question 41

photosensitivity rxns drugs

Answer 41

sulfonamides amiodarone tetracycline

Question 42

agranulocytosis drugs

Answer 42

clozapine carbamazepine colchicine

Question 43

drugs with gynecomastia

Answer 43

``` spironolactone digitalis cimetidine estrogen ketoconazole ```

Question 44

fructose intolerance

Answer 44

hypoglycemia, jaundices, cirrhosis increased fructose 1-P decreased phosphate aldolase B deficient

Question 45

avoid with hereditary fructose intolerance

Answer 45

fructose and sucrose

Question 46

asymptomatic with fructose in urine

Answer 46

essential fructosuria deficient - fructokinase

Question 47

genetic of fructose intolerance

Answer 47

auto recessive