Definitions Flashcards
What are the three types of validity?
Construct, face, and predictive
What is construct validity?
It assess how good the theoretical rationale for a model is. Does the creation of the model seem similar to the causes of the human condition (is the same gene affected, are they both caused in development etc.)?
What is face validity?
How good the similarities with the human condition are. Are the symptoms similar? Are the effects on the body similar?
What is predictive validity?
A measure of how accurate the predictions made from the model are. Are the effects of treatments similar? Is the disease progression similar?
Colony forming unit (CFU)
A single unit that will go on to form an aggregate of bacteria
A single unit that will go on to form an aggregate of bacteria
Colony forming unit (CFU)
What are CFUs used for?
To quantify the viable cells in a sample per millilitre
How are CFUs determined?
By culturing bacteria on agar plates, and counting the number of colonies produced
Plaque forming unit (PFU)
A virion that will go on to form a plaque in culture (often measured/ml)
A virion that will go on to form a plaque in culture (often measured/ml)
Plaque forming unit (PFU)
Plaque (in terms of PFUs)
A small circular area of cytolysis in a monolayer of susceptible cultured target cells in which a single infectious virion initiated an infectious focus
A small circular area of cytolysis in a monolayer of susceptible cultured target cells in which a single infectious virion initiated an infectious focus
Plaque (in terms of PFUs)
Hapten
A small molecule that can specifically bind an antibody but can only stimulate production of antibodies when conjugated to a larger carrier molecule
A small molecule that can specifically bind an antibody but can only stimulate production of antibodies when conjugated to a larger carrier molecule
Hapten
Cre recombinase
A bacteriophage enzyme that catalyses site-specific recombination of DNA between loxP sites, under the control of a specific promoter
A bacteriophage enzyme that catalyses site-specific recombination of DNA between loxP sites, under the control of a specific promoter
Cre recombinase
Lytic virus
A virus that replicates in the host cell, using host cell machinery, that causes death and lysis of the cell due to direct cytopathic effects
A virus that replicates in the host cell, using host cell machinery, that causes death and lysis of the cell due to direct cytopathic effects
Lytic virus
Latent virus
Where a virus is present within a host but is dormant and not replicating
Where a virus is present within a host but is dormant and not replicating
Latent virus
Outside-in signalling
Ligand binding event outside the cell which results in the activation of cell surface receptor and triggering of the intracellular response to the detected environmental cue
Ligand binding event outside the cell which results in the activation of cell surface receptor and triggering of the intracellular response to the detected environmental cue
Outside-in signalling
Opsonisation
Process by which bacteria and other pathogens are altered by opsins to become more readily phagocytosed
Process by which bacteria and other pathogens are altered by opsins to become more readily phagocytosed
Opsonisation
