Definitions

Question 1

Define pharmacokinetics

Answer 1

Balance between accumulation and elimination

Question 2

Factors that infuence tissue drug concentration

Answer 2

Absorption, Distribution, Metabolism, Elimination

Question 3

Define pharmacodynamics

Answer 3

Effect of drug on human body

Question 4

Pharmacogenetics

Answer 4

Genetic factors affecting drug metabolism e.g. polymorphisms

Question 5

Absorption

Answer 5

Transfer of drug from site of administration to blood stream

Question 6

Mechanisms of drug absorption

Answer 6

Active (against gradient, need energy, often need enzyme help) and Passive (with gradient, not needing energy)

Question 7

By what age are active and passive methods of absorption are fully matured?

Answer 7

4 months

Question 8

Factors affecting oral absorption include

Answer 8

Gastric acid secretion, gastric emptying time, bile salt foemation, intestinal motility, microbial flora

Question 9

Example of lipophillic drug

Answer 9

Diazepam

Question 10

What is first pass metabolism

Answer 10

Pre systemic metabolism i.e. extent to which oral drug is reduced after it’s first passage through an organ prior to reaching systemic circulation (liver, lungs, vascular endothelium)