Definitions Flashcards

1
Q

Risk

A

The PROBABILITY that an adverse effect will result under specified conditions

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2
Q

Risk assessment of toxicants

A

a characterization of hazard from exposure to environmental chemicals.
Involves understanding the toxicity of the chemical(s), exposure, and characteristics of exposed population

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3
Q

Epidemiology

A

Human studies

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4
Q

Cohort

A

prospective in design

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5
Q

Case-Control

A

retrospective in nature

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6
Q

Studying humans

A

no need for cross-species extrapolation

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7
Q

Risk Characterization

A

Combining information from first three steps in risk assessment

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8
Q

Risk Management

A

Making decisions to reduce/manage risk. Different process than risk assessment

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9
Q

Health Risk Assessment

A

The characterization of the potential adverse health effects of human exposures to environmental hazards

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10
Q

Ecological Risk Assessment

A

the process for evaluating how likely it is that the environment may be impacted as a result of exposure to one or more environmental stressors such as chemicals, land change, disease, invasive species and climate change

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11
Q

“Risk managers”

A

federal or state officials whose job it is to protect the environment, e.g., CA Air Resources Board or USEPA Risk Managers but can also be:
business leaders who work at companies that can impact the environment, or
private citizens who are making decisions regarding risk.

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12
Q

Chemical-specific risk assessments

A

refers to applying the 4 steps to a single chemical

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13
Q

Site-specific risk assessment

A

applies the 4 steps to specific locations or scenarios

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14
Q

Hazard Identification

A

The process of determining what adverse effects are caused by exposure to an agent

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15
Q

Dose-Response Assessment

A

The process of quantifying the relationship between the exposure or dose of a chemical and the adverse effect

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16
Q

Exposure Assessment

A

The process of quantifying the amount of exposure to an environmental chemical humans receive from a single or multiple media

17
Q

Risk Characterization

A

The process of combining the first three steps of risk assessment into a coherent picture describing the risks of exposure to the chemical(s) in question

18
Q

Adverse effect

A

a biochemical change, functional impairment, or pathologic lesion that affects the performance of the whole organism, or reduces an organism’s ability to respond to an additional environmental challenge

19
Q

Pharmacokinetic studies

A

how your body handles the chemical:Absorption,

Distribution, Metabolism, Excretion

20
Q

Mode of Action

A

describes how a chemical causes toxicity in a general way

21
Q

Mechanism of action

A

this term usually specifies how a chemical causes toxicity from a mechanistic standpoint

22
Q

Case Reports

A

Usually a report of one or a few people experiencing adverse effects after an exposure

23
Q

“in vitro”

A

not in a whole animal, e.g. testing cells or tissues

24
Q

Toxicology assays

A

identifying early biological changes from chemical exposure