Deck Flashcards
Grignard
No OH
Grignard with primary alkyl halide
Makes new c-c bond
Strong base grignard
Only reduce once, just right, O to H:-
(Stops at alkyl halide)
Baby bear, DIBAL-H
Gentler less reactive reducing agent O to H:
Caregiver bear NaBH4 MeOH
Reducing evertyhing possible replace bonds O woth H:-
Monster LiAlH4
Reaction at alpha carbon halogenation acid and base
Grignard react with esters or acid chlorides
1,2 and 1,4 addition
Grignard react with carbonyl carbons
Kinetic vs thermodynamic
Crossed aldol
Mixed and direct aldol
Transesterification with acid or base
Strong base with alpha carbon
Heal the cleaver with
Tone down to react with c.a. Kt ester not ketone
Self condensation aldol with mild base or acid
Controllable Beta-ketoester
How to make a ring
React with bears
Michael addition enolate and aldol
Claisen
Tautomerization